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Contraception clinical trials

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NCT ID: NCT03657602 Not yet recruiting - Contraception Clinical Trials

Immediate Postpartum Insertion of Contraceptive Intrauterine Devices

Start date: September 2018
Phase: Early Phase 1
Study type: Interventional

In this randomized trial, investigators intend to determine the expulsion and discontinuation rate of immediate postpartum intrauterine devices in the patient population of the University of Oklahoma Women's Healthcare Specialists Clinic (OUWHSC).

NCT ID: NCT03656289 Not yet recruiting - Contraception Clinical Trials

Antepartum Etonogestrel Contraceptive Implant Insertion at Term

Start date: October 1, 2018
Phase: Phase 1
Study type: Interventional

Short-interval pregnancy (SIP) or rapid, repeat pregnancy is defined as a pregnancy within one year of prior delivery. These pregnancies are often unintended and are associated with adverse risks. Low contraceptive initiation during the postpartum period is a contributing factor to SIP. This study will be the first to investigate the initiation of a highly-effective, immediately active contraceptive device during the antepartum period. The antepartum period serves as an ideal time for postpartum contraception counseling, due to patients' active involvement with the healthcare system. The pharmacokinetic analysis proposed in this study will be the first to investigate whether and to what extent ENG hormone crosses the placenta. This data will enrich understanding of the pharmacology of exogenous progestins administered during pregnancy and provide information that can be incorporated into future patient counseling regarding the risks of fetal exposure with exogenous progestin use.

NCT ID: NCT03598088 Recruiting - Contraception Clinical Trials

Safety and Acceptability Study of a Non-Hormonal Ring

Start date: May 23, 2018
Phase: N/A
Study type: Interventional

This is a feasibility, multi-center, open-label, non-significant risk device study for a non-hormonal contraceptive ring.

NCT ID: NCT03589040 Not yet recruiting - HIV Clinical Trials

Darunavir and Rilpivirine Interactions With Etonogestrel Contraceptive Implant

DRIVE-1
Start date: August 2018
Phase: Phase 2
Study type: Interventional

This study will evaluate the pharmacokinetic properties of rilpivirine and darunavir when used in combination with etonogestrel

NCT ID: NCT03589027 Recruiting - Contraception Clinical Trials

Darunavir and Rilpivirine Interactions With Levonorgestrel Implant

DRIVE-2
Start date: August 7, 2018
Phase: Phase 2
Study type: Interventional

This study will evaluate the pharmacokinetic properties of Rilpivirine and Darunavir when used in combination with Levonorgestrel

NCT ID: NCT03585712 Recruiting - Contraception Clinical Trials

Effect of Norgestrel 75 mcg Study on Cervical Mucus and Ovarian Activity During Perfect Use, After One Delayed Intake and After a Missed Pill

Start date: July 24, 2018
Phase: Phase 2
Study type: Interventional

Norgestrel 75 mcg is a progestin-only pill (POP), which is a kind of oral birth control pill. To be effective in preventing pregnancy, this kind of birth control pill is supposed to be taken every day at the same time, without delaying the intake for more than 3 hours. This study aims to find out if taking the pill 6 hours late or not taking it for one day will affect the way it works.

NCT ID: NCT03585361 Completed - Pregnancy Clinical Trials

Utilizing All Health System Contacts to Offer Postpartum Family Planning (PPFP) in Ethiopia

Start date: February 20, 2017
Phase: N/A
Study type: Interventional

This study is investigating whether use of postpartum family planning (PPFP) increases if messages on PPFP and, if desired, PPFP services are integrated into as many contacts as possible between women/couples and the health system during pregnancy and the first year after birth. Health system contacts may be at health facilities (including antenatal, labor and delivery, postnatal, and child immunization visits) or, with Ethiopia's Health Extension Program, at households or health posts in the community.

NCT ID: NCT03571932 Completed - Contraception Clinical Trials

Assessment of Family Planning and Immunization Service Integration in Liberia

Start date: November 2016
Phase:
Study type: Observational

This is a mixed methods process evaluation of a programmatic intervention to integrate family planning and immunization services at health facilities in Lofa and Grand Bassa counties in Liberia. MCSP used a longitudinal, pair-matched design to monitor the effect of integrating immunization and FP services on utilization of FP and routine immunization services. In Lofa and Grand Bassa counties, 36 facilities were pair-matched to intervention and comparison sites based on predetermined criteria. After approximately 9 months of implementation, MCSP conducted a qualitative study employing key informant interviews (KIIs) and focus group discussions (FGDs) at intervention and comparison sites, and with district-, county-, and national-level MOH supervisors and managers.

NCT ID: NCT03562624 Recruiting - Contraception Clinical Trials

A Study to Compare 3 Doses of a Hormonal Intra-uterine Device Containing Levonorgestrel and Indomethacin With a Hormonal Intra-uterine Device Containing Only Levonorgestrel to Assess the Effect and Safety of the Combined Components

INDessa
Start date: June 22, 2018
Phase: Phase 2
Study type: Interventional

This study is the first study investigating the combined intrauterine administration of LNG (levonorgestrel) and IND (indomethacin). It is a combined proof-of-concept (PoC) and dose finding (DF) study in pre-menopausal women. It is designed to investigate the pharmacodynamics (PD) of BAY 987443 (i.e. IUS (intrauterine system) releasing LNG and IND), as well as pharmacokinetics (PK) of both active substances, safety and tolerability. In this study, Jaydess, as an LNG-only IUS, will be used as a comparator.

NCT ID: NCT03559634 Not yet recruiting - Contraception Clinical Trials

Contraception Initiation Feasibility in the Pediatric ED

Start date: August 2018
Phase: N/A
Study type: Interventional

Many adolescents using the pediatric emergency department (ED) are at higher risk for unintended pregnancy. This is a significant public health issue and hormonal contraception is the mainstay of prevention. Many barriers to hormonal contraception exist and other studies have demonstrated that referral from the ED for hormonal contraception leads to poor follow up. This study will be a pilot study to assess the feasibility of two implementation strategies for initiating contraception in the pediatric ED, a limited medication offering and a more comprehensive medication offering.