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Contraception clinical trials

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NCT ID: NCT03347539 Not yet recruiting - Contraception Clinical Trials

Implants on Mobile Health Unit

Start date: December 2017
Phase: N/A
Study type: Observational

This study explores reasons why adolescents choose to receive a nexplanon implant and remove a Nexplanon implant. Nexplanon is provided as part of the standard of care on the University of Chicago mobile health unit. This study explores reasons for implantation and removal of Nexplanon on this mobile health unit.

NCT ID: NCT03335163 Not yet recruiting - Contraception Clinical Trials

The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users

Start date: November 15, 2017
Phase: Phase 1
Study type: Interventional

A prospective, non-inferiority study to evaluate the pharmacokinetic effect of topiramate on serum Etonogestrel (ENG) levels in contraceptive implant users.

NCT ID: NCT03307863 Recruiting - Contraception Clinical Trials

Effect of Anti-epileptic Drugs on Etonogestrel-releasing Implant Pharmacokinetics in Women With Epilepsy

Start date: October 2017
Phase: Phase 4
Study type: Interventional

Data on the interaction between the etonogestrel (ENG) implant and antiepileptic drug (AED) regimen are scarce. We will evaluated the effect of 2 AED regimens (1 including carbamazepine and the other topiramate) on the pharmacokinetic (PK) parameters of an ENG-releasing implant in women with epilepsy.

NCT ID: NCT03305081 Terminated - Contraception Clinical Trials

Patient Compliance With Long-Acting Reversible Contraception Administration

Start date: October 22, 2014
Phase: Phase 4
Study type: Interventional

This a randomized control trial to identify if patients who desire LARC are more likely to have success receiving the desired form of contraception if it is placed a) during the postpartum hospital stay, either in the immediate or early postpartum period, versus b) during the interval postpartum period as previously done.

NCT ID: NCT03301480 Recruiting - Hiv Clinical Trials

Contraceptive/HIV Affecting Risk in Adolescents

CHARA
Start date: July 31, 2017
Phase: N/A
Study type: Observational

This study will evaluate the impact of hormonal contraceptives on HIV risk associated with changes to the innate immunity in the female genital tract in a cross-sectional study. HIV risk will be evaluated by the capacity of cervical tissue to replicate HIV when challenged ex vivo and correlated to the number of CD4 T cells, DCs, and macrophages; the capacity of cervicovaginal fluid to inhibit HIV will be correlated to soluble mucosal mediators, and the vaginal microbiota. The lower genital tract samples will be collected from 120 adolescents aged 18-19 (40 using no hormonal contraception, 40 using ENG-I, 40 using LNG-IUS). For comparison, 90 adult women aged 25-45 will be equally distributed between the same groupings.

NCT ID: NCT03299179 Recruiting - Contraception Clinical Trials

The Effects of the Female Hormones on Cerebral Perfusion

Start date: October 3, 2016
Phase: N/A
Study type: Observational

Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the variations in cerebral perfusion and other brain parameters (grey matter, resting-state brain activity, brain connectivity and white matter diffusion) caused by the female sex hormones and hormonal contraception.

NCT ID: NCT03296098 Not yet recruiting - Contraception Clinical Trials

Study of the Safety and Efficacy of Ulipristal Acetate (UPA) Used Daily as a Contraceptive

CCN013B
Start date: October 2017
Phase: Phase 2
Study type: Interventional

This is a Phase IIb multicenter, open-label, non-comparative trial of continuous daily oral 10 mg of ulipristal acetate (UPA) to evaluate its contraceptive efficacy as the primary method of contraception.

NCT ID: NCT03282799 Not yet recruiting - Contraception Clinical Trials

Pharmacologic Strategies for the Etonogestrel Implant in HIV-Infected Women

Start date: January 2018
Phase: Phase 2
Study type: Interventional

This study will evaluate the frequency of ovulation and cervical mucus quality of HIV-infected women on efavirenz (EFV)-based antiretroviral therapy (ART) using either a single etonogestrel (ENG) implant or two ENG implants for at least one year.

NCT ID: NCT03255941 Not yet recruiting - Contraception Clinical Trials

Clinical Study of Depo Provera Comparing Lay Health Workers and Clinically-trained Health Workers

Start date: November 15, 2017
Phase: Early Phase 1
Study type: Interventional

This is a randomized controlled trial comparing lay Lady Health Workers with Lady Health Visitors on quantitative measures of safety and effectiveness of Depo Provera and Sayana Press provision in a clinic setting. This comparative trial will test the non-inferiority hypothesis that Lady Health Workers are just as competent as clinically-trained Lady Health Visitors in screening and counseling first-time injectable users. These first time users will also be randomly assigned to receive intramuscular or subcutaneous injections of DMPA.

NCT ID: NCT03243305 Recruiting - Contraception Clinical Trials

AMP002 Phase III Contraceptive Study

Start date: July 27, 2017
Phase: Phase 3
Study type: Interventional

This is a single-arm, open-label, Phase III study in approximately 100 sites in the United States (US) over seven cycles of use in women aged 18 to 35 years who are at risk of pregnancy.