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NCT ID: NCT00903331 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study

MUSIC
Start date: May 2009
Phase: Phase 2
Study type: Interventional

The AC-055B201/MUSIC study is a Phase II study, comparing one dose of ACT-064922 (macitentan) 10 mg with placebo in patients with idiopathic pulmonary fibrosis (IPF). The main study objective is to demonstrate that macitentan positively affects the forced vital capacity (FVC) in comparison with placebo in patients with idiopathic pulmonary fibrosis (IPF). The secondary objectives are to evaluate the effect of macitentan on the time to disease worsening or death in patients with IPF, and to evaluate the benefit/risk profile of macitentan in the treatment of patients with IPF.

NCT ID: NCT00903110 Recruiting - IGF1 Deficiency Clinical Trials

Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).

Start date: December 9, 2008
Phase:
Study type: Observational [Patient Registry]

The Increlex® Global Registry is a descriptive, multicenter, observational, prospective, open-ended, non interventional, post-authorisation surveillance registry. The main purpose of this global registry is to collect, analyse and report safety data during and up to at least 5 years after the end of treatment in children and adolescents receiving Increlex® therapy for SPIGFD according to the locally approved product information.

NCT ID: NCT00902993 Completed - Healthy Clinical Trials

Study to Investigate Safety, Tolerability and Pharmacokinetics With Single and Multiple Ascending Doses of AZD1446

Start date: April 2009
Phase: Phase 1
Study type: Interventional

This study is designed to evaluate the safety, tolerability and PK of AZD1446 in Subjects when given as multiple dose administration for either 7 Days (Day 1 single dose, Day 2-6 multiple doses) in Part A and optionally at fractionated doses for 1 Day in Part B.

NCT ID: NCT00902928 Completed - Clinical trials for Venous Thromboembolism

A Study Evaluating Efficacy and Safety of YM150 Compared to Enoxaparin in Subjects Undergoing Hip Replacement Surgery

ONYX-3
Start date: April 2009
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of various doses of YM150 (the experimental drug) compared to enoxaparin in the prevention of venous thromboembolism in patients that are undergoing elective hip replacement surgery.

NCT ID: NCT00902642 Completed - Pain Clinical Trials

What is the Effect of a Course for Treatment Providers on Their Patient Outcome

Start date: September 2004
Phase: N/A
Study type: Interventional

The goal is to acquire more in-depth knowledge on physical therapists' attitudes towards and beliefs about psychosocial factors in back pain, how physical therapists integrate psychosocial factors into their clinical practice and the effects of a training program for physical therapists in psychosocial factors on clinical practice and thereby on patient outcome in terms of disability, pain, catastrophizing, and treatment satisfaction.

NCT ID: NCT00902174 Completed - Clinical trials for Pulmonary Arterial Hypertension

Imatinib (QTI571) in Pulmonary Arterial Hypertension

IMPRES
Start date: September 2009
Phase: Phase 3
Study type: Interventional

A multinational, multicenter, double blind, placebo-controlled study evaluating the efficacy and safety of imatinib as an add-on therapy in the treatment of patients with severe pulmonary arterial hypertension (PAH).

NCT ID: NCT00901914 Completed - Clinical trials for Rhinitis, Allergic, Seasonal

Study of rBet v1 Tablets

Start date: October 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of three doses of r Bet v1 administered as sublingual tablets in birch pollen allergic subjects.

NCT ID: NCT00900822 Completed - Alveolar Bone Loss Clinical Trials

Straumann Bone Ceramic Versus BioOss in Sinus Elevation

Start date: November 2005
Phase: N/A
Study type: Interventional

Straumann Bone Ceramic (SBC) and BioOss will be used as bone grafting materials when there is a need for bone augmentation in the posterior upper jaw. 9 months later the bone formation is evaluated. The patients are followed for 3 years.The study hypothesis is that the SBC is not worse than BioOss.

NCT ID: NCT00900627 Completed - Breast Cancer Clinical Trials

Phase I/II AZD8931/Paclitaxel in Treatment of Advanced Solid Tumours (Phase I) and Advanced Breast Cancer (Phase II)

THYME
Start date: June 2009
Phase: Phase 1/Phase 2
Study type: Interventional

The main purpose of this study is to determine if AZD8931 can improve the efficacy of standard chemotherapy for the treatment of advanced breast cancer. This study will be conducted in 2 parts: the first part (phase I) will determine a dose of AZD8931 that can be safely administered with paclitaxel chemotherapy. The second part (phase II) will determine the efficacy and safety of AZD8931 in combination with paclitaxel chemotherapy in breast cancer.

NCT ID: NCT00900614 Completed - Prostatic Neoplasms Clinical Trials

Safety Study of APR-246 in Patients With Refractory Hematologic Cancer or Prostate Cancer

Start date: May 2009
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the highest feasible dose (HFD) of intravenous (IV) APR-246 when given to patients with refractory hematologic malignancies or prostate carcinoma.