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Idiopathic Pulmonary Fibrosis clinical trials

View clinical trials related to Idiopathic Pulmonary Fibrosis.

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NCT ID: NCT02772549 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Early Diagnosis of Pulmonary Fibrosis - Diagnostic Delay

Start date: March 2016
Phase: N/A
Study type: Observational [Patient Registry]

Patients with newly diagnosed IPF are investigated for the diagnostic delay before a diagnosis of IPF is made.

NCT ID: NCT02759120 Not yet recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Study of Clinical Efficacy of Antimicrobial Therapy Strategy Using Pragmatic Design in Idiopathic Pulmonary Fibrosis

CleanUp-IPF
Start date: June 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effect of standard care versus standard care plus antimicrobial therapy (co-trimoxazole or doxycycline) on clinical outcomes in patients diagnosed with idiopathic pulmonary fibrosis (IPF).

NCT ID: NCT02758808 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis (IPF)

Pulmonary Fibrosis Foundation Patient Registry

PFFR
Start date: March 2016
Phase: N/A
Study type: Observational [Patient Registry]

The Pulmonary Fibrosis Foundation Patient Registry will collect data on at least 2,000 patients with interstitial lung disease (ILD) at approximately 40 clinical sites in the US. The Registry is targeting enrollment of approximately 60% of the 2,000 ILD participants to have idiopathic pulmonary fibrosis (IPF). The aim of the Registry is to create a cohort of well-characterized patients with interstitial lung disease (ILD) for participation in retrospective and prospective research

NCT ID: NCT02755441 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Early Diagnosis of Pulmonary Fibrosis - Use of Biomarkers in Idiopathic Pulmonary Fibrosis

Start date: April 2016
Phase: N/A
Study type: Observational

All incident cases of idiopathic pulmonary fibrosis (IPF) in Denmark will be offered inclusion during a 2 year period and followed up for at least 1 year with measurements of serum biomarkers and measurements of disease progression.

NCT ID: NCT02745184 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Clinical Efficacy and Safety of Autologous Lung Stem Cell Transplantation in Patients With Idiopathic Pulmonary Fibrosis

Start date: April 2016
Phase: Phase 1/Phase 2
Study type: Interventional

Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive damage of lung structure and decline in lung function.This study intends to carry out an open, single-center, non-randomized, self control phase I clinical trial. During the treatment, lung stem cells will be isolated from patients' own bronchi and expanded in vitro. Cultured cells will be injected directly into the lesion by fiberoptic bronchoscopy after lavage. After twelve-month observation, the investigators will evaluate the safety and efficacy of the treatment by measuring the key clinical indicators.

NCT ID: NCT02739165 Not yet recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Clinical Study of ART-123 for the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Start date: May 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy and safety of the intravenous drip infusion of ART-123 in patients with acute exacerbation of idiopathic pulmonary fibrosis (IPF) in a multicenter, double-blind, randomized, placebo-controlled, parallel group comparison study, and to confirm its superiority over placebo with survival rate on Day 90 as the primary endpoint.

NCT ID: NCT02738801 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Study to Assess Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of GLPG1690

Start date: March 2016
Phase: Phase 2
Study type: Interventional

A multicenter randomized, double-blind, parallel group, placebo-controlled, exploratory phase IIa study in subjects with Idiopathic Pulmonary Fibrosis (IPF) to evaluate safety, tolerability, PK and PD of GLPG1690. Male and female subjects aged 40 years or older will be screened to determine eligibility. The screening period will be up to 4 weeks. At baseline, eligible subjects will be randomized in a 3:1 ratio to GLPG1690 or matching placebo administered for 12 weeks. The subjects will visit the study center at screening, baseline, week 1, 2, 4, 8 and 12 and for a follow up visit 2 weeks after the last administration of study drug. Planned assessments: Adverse event reporting, clinical laboratory tests, vital signs, physical examination, 12-Lead-ECG, PK blood sampling, biomarker blood/BALF samples, Spirometry, St George's respiratory questionnaire, high-resolution computed tomography (HRCT).

NCT ID: NCT02707640 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

A Study to Assess the Safety and Tolerability of N-Acetylcysteine When Administered With Pirfenidone to Participants With Idiopathic Pulmonary Fibrosis (IPF)

Start date: August 2013
Phase: Phase 2
Study type: Interventional

This is a Phase 2, randomized, double-blind, placebo-controlled safety and tolerability study of N-acetylcysteine or placebo in participants with mild to moderate idiopathic pulmonary fibrosis (IPF) receiving background pirfenidone therapy.

NCT ID: NCT02699879 Active, not recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Evaluation of Long-Term Safety of Pirfenidone (Esbriet) in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Start date: February 2012
Phase: N/A
Study type: Observational

This single arm, post-authorisation study is designed to evaluate the long-term safety of pirfenidone in participants with IPF. The enrolment of participants will be completed within approximately 24 months. Participants will receive pirfenidone according to the physician discretion and will be followed for 2 years. Treating physicians will collect pre-specified data at the baseline and every 3 months thereafter, for the duration of the participants' participation in study.

NCT ID: NCT02688647 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

A Study to Evaluate the Safety, Tolerability, and Activity of KD025 in Subjects With Idiopathic Pulmonary Fibrosis

Start date: March 2016
Phase: Phase 2
Study type: Interventional

This study is being conducted to evaluate the safety, tolerability, and activity of 400 mg of KD025 once-daily (QD) compared to standard of care (SOC) in male and postmenopausal/surgically sterilized female subjects with IPF.