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Idiopathic Pulmonary Fibrosis clinical trials

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NCT ID: NCT03229343 Not yet recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Impact of a Systematic Palliative Care on Quality of Life, in Advanced Idiopathic Pulmonary Fibrosis.

PALIF
Start date: August 2017
Phase: N/A
Study type: Interventional

Idiopathic pulmonary fibrosis (IPF) is a rare and severe disease with a survival median between 2 and 4 years which leads to a profound alteration of the quality of life. In thoracic oncology, the systematic and early intervention of a palliative care team result in an improvement of quality of life for patients. In the princeps study published in 2010, the early intervention of a dedicated palliative care team was compared to standard care in a randomized trial of 150 patients and shows a significant improvement : (i) of quality of life (main objective), (ii) of depression scores and even overall survival (11.6 months vs. 8.9 months, P = 0.02), (iii) a benefit in terms of understanding the diagnosis and therapeutic goals (3), (iv) diminution of adapted hospitalization in end of life (in emergency or not). Considering some analogy points between IPF and advanced lung cancer (prognosis, respiratory symptom, psychological burden), it seemed reasonable to assume that the joint systematic intervention of chest physician and palliative care team may provide a significant benefit in terms of quality of life for patients with severe IPF.

NCT ID: NCT03222648 Not yet recruiting - Quality of Life Clinical Trials

Structured Exercise Training Programme in Idiopathic Pulmonary Fibrosis

Rehab-IPF
Start date: August 2017
Phase: N/A
Study type: Interventional

In this single centre non-randomised pilot cohort study we wish to quantify the effect of a twice weekly, 8 week, structured responsive exercise training programme on exercise tolerance, symptoms and health related quality of life in patients with Idiopathic Pulmonary Fibrosis (IPF). We also wish to assess the effect of exercise training on fibrotic processes causing IPF through measurement of blood biomarkers of disease activity.

NCT ID: NCT03215147 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Prevalence and Impact on Quality of Life of Airway Disease in Patients With Idiopathic Pulmonary Fibrosis

Start date: June 7, 2017
Phase: N/A
Study type: Observational [Patient Registry]

The investigators assess the prevalence of airway disease associated with idiopathic pulmonary fibrosis in Korea, and evaluate the effect of these airway diseases on the symptoms and quality of life of patients with idiopathic pulmonary fibrosis.

NCT ID: NCT03211507 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis Job Exposures Study

IPFJES
Start date: May 1, 2017
Phase: N/A
Study type: Observational

A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.

NCT ID: NCT03208933 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Open-label Study to Assess the Effectiveness of Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis (IPF).

Start date: June 23, 2017
Phase: Phase 3
Study type: Interventional

This study is a national, multicenter, interventional, non-randomized, non-controlled, open-label study to assess the effectiveness of pirfenidone in participants with IPF in Russian clinical practice.

NCT ID: NCT03183570 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Detection of Integrin avb6 in Idiopathic Pulmonary Fibrosis Using PET/CT

Start date: August 15, 2017
Phase: Early Phase 1
Study type: Interventional

The investigators wish to evaluate the feasibility of [18F]FP-R01-MG-F2 PET/CT scanning in patients with Idiopathic Pulmonary Fibrosis.

NCT ID: NCT03171870 Not yet recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Characteristics and Health Related Quality of Life in Idiopathic Pulmonary Fibrosis

Start date: June 2017
Phase: N/A
Study type: Interventional

Idiopathic pulmonary fibrosis is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia. The definition of Idiopathic pulmonary fibrosis requires the exclusion of other forms of interstitial pneumonia including other idiopathic interstitial pneumonias and Interstitial lung disease associated with environmental exposure, medication, or systemic disease. Prevalence estimates for Idiopathic pulmonary fibrosis have varied from 2 to 29 cases per 100,000 in the general population IPF should be considered in all adult patients with unexplained chronic exertional dyspnea, and commonly presents with cough, bibasilar inspiratory crackles, and finger clubbing.

NCT ID: NCT03142191 Not yet recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

A Study to Evaluate the Efficacy and Safety of CC-90001 in Subjects With Idiopathic Pulmonary Fibrosis

Start date: May 5, 2017
Phase: Phase 2
Study type: Interventional

This is a Phase 2, multicenter, multinational, randomized, double-blind, placebo-controlled study evaluating the efficacy, safety, pharmacokinetics (PK), quality of life and exploratory pharmacodynamics (PD) of two treatment doses of CC-90001, 200 mg and 400 mg, compared with placebo, when delivered once daily per os (PO) in subjects with idiopathic pulmonary fibrosis (IPF). This study is designed to assess response to treatment by using measures of lung function, disease progression, fibrosis on radiography, and patient-reported outcomes. It will also assess dose response.

NCT ID: NCT03120481 Recruiting - Asthma Clinical Trials

Controls for Respiratory Diseases

Start date: April 10, 2017
Phase: N/A
Study type: Observational [Patient Registry]

This is the registry of control participants for patients with various respiratory diseases. We screened healthy volunteers who visited Seoul National Hospital Healthcare System Gangnam Center for routine health check-up, and enrolled patients who agree to participate in the study. The participants undergo baseline questionnaires, provide blood specimen and information of the results of health check-up. We will include participants as controls if they have no significant respiratory symptom and no significant radiographic abnormality. The data from this registry will be compared with those from other registry of various respiratory diseases

NCT ID: NCT03115619 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Quality of Life Study in Participants With IPF Under Pirfenidone Treatment

PNEUMON
Start date: April 18, 2017
Phase: N/A
Study type: Observational

This multicenter, post-marketing, observational study will evaluate quality of life in participants with Idiopathic Pulmonary Fibrosis (IPF) under treatment with pirfenidone (Esbriet).