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NCT ID: NCT00435409 Completed - Breast Neoplasms Clinical Trials

A Study Of Sunitinib In Combination With Capecitabine Compared With Capecitabine In Patients With Breast Cancer

Start date: February 2007
Phase: Phase 3
Study type: Interventional

The treatment received with sunitinib plus capecitabine could delay tumor growth longer than with treatment with capecitabine alone.

NCT ID: NCT00435279 Completed - Clinical trials for Major Depressive Disorder

A Study of Eszopiclone Co-administered With Venlafaxine in Subjects With Major Depressive Disorder and Insomnia

Start date: June 2007
Phase: Phase 3
Study type: Interventional

To evaluate the antidepressant effect of adjunctive treatment with Eszopiclone in subjects receiving venlafaxine for the treatment of Major Depressive Disorder (MDD).

NCT ID: NCT00435019 Completed - Diabetes Clinical Trials

Comparison of NPH Insulin and Insulin Detemir in Children and Adolescents With Type 1 Diabetes

Start date: February 2007
Phase: Phase 3
Study type: Interventional

This trial is conducted in Europe. The aim of this research is to compare the efficacy and safety of treatment with NPH insulin and insulin detemir. You will be treated with either insulin detemir or NPH insulin once or twice daily as basal insulin. Additionally you will receive insulin aspart as bolus insulin

NCT ID: NCT00434967 Completed - Hypertension Clinical Trials

Antihypertensive Efficacy and Safety of Candesartan/HCT 32/25 mg in Comparison With Individual Components and Placebo

Start date: January 2007
Phase: Phase 3
Study type: Interventional

The aim is to compare the blood pressure lowering effect of the combination of candesartan cilexetil (candesartan) 32 mg and hydrochlorothiazide (HCT) 25 mg to that of candesartan 32 mg alone, HCT 25 mg alone and placebo in hypertensive adults.

NCT ID: NCT00433290 Completed - Clinical trials for Osteoarthritis Knee Pain

Duloxetine vs. Placebo in the Treatment of Osteoarthritis Knee Pain

Start date: February 2007
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to determine if duloxetine reduces pain severity in patients with osteoarthritis knee pain.

NCT ID: NCT00431561 Completed - Glioblastoma Clinical Trials

Phase IIb Clinical Trial With TGF-β2 Antisense Compound AP 12009 for Recurrent or Refractory High-grade Glioma

Start date: April 2003
Phase: Phase 2
Study type: Interventional

In this multinational dose finding Phase IIb study the efficacy and safety of two doses of AP 12009 compared to standard chemotherapy (temozolomide or PCV) is investigated in adult patients with confirmed recurrent high-grade glioma.

NCT ID: NCT00430898 Completed - Ulcerative Colitis Clinical Trials

Basiliximab in Moderate to Severe Ulcerative Colitis

Start date: January 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety, effectiveness and pharmacokinetics of two levels of intravenous basiliximab in ulcerative colitis, compared to placebo.

NCT ID: NCT00430729 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease. Ratio-Study. (BY217/M2-112)

Start date: January 2003
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the effect of 500mcg roflumilast vs placebo on exacerbation rate and pulmonary function as well as quality of life in patients with chronic obstructive pulmonary disease (COPD).

NCT ID: NCT00430625 Completed - Clinical trials for Gaucher Disease, Type 1

A Study of Gene-Activated® Human Glucocerebrosidase (GA-GCB) Enzyme Replacement Therapy in Gaucher Disease

Start date: February 15, 2007
Phase: Phase 3
Study type: Interventional

Gaucher disease is a rare lysosomal storage disorder caused by the deficiency of the enzyme glucocerebrosidase (GCB). Due to this deficiency of functional GCB, glucocerebroside accumulates within macrophages leading to cellular engorgement, organomegaly, and organ system dysfunction. The purpose of this study is to evaluate the efficacy of every other week dosing of Gene-Activated® Human Glucocerebrosidase (GA-GCB, velaglucerase alfa) at doses of 45 and 60 U/kg in treatment-naïve patients with type 1 Gaucher disease.

NCT ID: NCT00430352 Completed - Clinical trials for Non-Hodgkin's Lymphoma

MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma.

Start date: September 2006
Phase: Phase 4
Study type: Interventional

This single arm study will evaluate the safety and efficacy of MabThera maintenance therapy following a MabThera-containing induction regimen in first line or relapsed patients with follicular non-Hodgkin's lymphoma. All patients will receive MabThera 375mg/m2 body surface area, as an intravenous infusion, every 8 weeks. The anticipated time on study treatment is 1-2 years, and the target sample size is 500+ individuals.