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Ulcerative Colitis clinical trials

View clinical trials related to Ulcerative Colitis.

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NCT ID: NCT03018925 Recruiting - Ulcerative Colitis Clinical Trials

Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis

GOLI2015
Start date: October 2016
Phase: N/A
Study type: Observational

This study aims to characterize the changes on intestinal microbiota pattern associated with the use of golimumab in order to determine if intestinal microbiota markers may correlate with golimumab therapeutic effect in patients naïve & non-naïve to anti-TNF treatment

NCT ID: NCT03016780 Recruiting - Ulcerative Colitis Clinical Trials

Fecal Microbiota Transplantation for Ulcerative Colitis

FMTFUC
Start date: July 2016
Phase: Phase 1/Phase 2
Study type: Interventional

Ulcerative colitis is a common digestive system disease, the incidence is increasing in recent years.It is reported that the occurrence and development of ulcerative colitis is closely related to imbalance of intestinal flora .Moreover,intestinal mucosal immunity may be related to intestinal flora. Fecal microbiota transplantation as a new technology to rebuild intestinal flora has been used for several diseaseļ¼Œbut the efficacy of ulcerative colitis by fecal microbiota transplantation needs to be further explored.

NCT ID: NCT03011593 Completed - Ulcerative Colitis Clinical Trials

Effect of UGIR in Adults With Compromised Gut Function and Malabsorption

Start date: November 2015
Phase: N/A
Study type: Interventional

This study assessed the effect of a nutrition support product on quality of life in adults with compromised gut function and malabsorption.

NCT ID: NCT03006809 Not yet recruiting - Ulcerative Colitis Clinical Trials

Optimal Fecal Microbiota Transplant Dosing for Mild to Moderate Ulcerative Colitis

Start date: February 2017
Phase: Phase 1
Study type: Interventional

This is a prospective unblinded, randomized trial for the use of Fecal Microbiota Transplantation (FMT) for the treatment of Ulcerative Colitis (UC), in combination with or without antibiotic pretreatment.

NCT ID: NCT03000101 Recruiting - Crohn's Disease Clinical Trials

Study of the Role of Pomegranate Juice Ellagitannins in the Modulation of Inflammation in Inflammatory Bowel Diseases

POME2016
Start date: December 2016
Phase: Phase 1
Study type: Interventional

The aim of this research is to study the effects of a pomegranate juice on calprotectin levels in patients suffering of inflammatory bowel diseases (IBD) in clinical remission. Fecal calprotectin levels, surrogate marker of mucosal inflammation, will be measured from baseline to 12 weeks later (end of intervention). Systemic and mucosal changes of biochemical and molecular inflammatory response markers will be also assessed.

NCT ID: NCT02998112 Recruiting - Ulcerative Colitis Clinical Trials

Fecal Microbiota Transplantation for Ulcerative Colitis Through Colonic Transendoscopic Enteral Tubing

Start date: December 2016
Phase: Phase 4
Study type: Interventional

To indicate the efficacy of Fecal microbiota transplantation (FMT) for the treatment of Ulcerative colitis (UC), The investigators design a multicenter, randomized controlled trial to perform FMT through colonic transendoscopic enteral tubing (TET) way, and evaluate the efficacy and safety of FMT for patients with moderate or severe UC.

NCT ID: NCT02994836 Not yet recruiting - Crohn's Disease Clinical Trials

GIS-SUSANTI-TNF-2015 (Anti-TNF Discontinuation )

Start date: January 2017
Phase: Phase 4
Study type: Interventional

This study will be a multicentre prospective randomized trial to assess the percentage of patients with IBD who, after stopping anti-TNF treatment, have sustained clinical remission at one year compared to those in which the treatment is continued at stable doses

NCT ID: NCT02962245 Not yet recruiting - Ulcerative Colitis Clinical Trials

Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis

Start date: November 2016
Phase: Phase 4
Study type: Interventional

The research aim to find out whether berberine can reduce the annual recurrence rate of ulcerative colitis in remission. A total of 238 patients with ulcerative colitis in remission will be randomly divided into two groups.One will receive regular treatment,and the other group will receive extra oral berberine 300 mg three times daily for a year. The end of the study for every patient is disease recurrence(Mayo Clinic score of 3 points or more ). The primary analysis is annual recurrence rate, and both endoscopy and Mayo Clinic disease activity index scores at the baseline and final assessments.

NCT ID: NCT02958865 Not yet recruiting - Ulcerative Colitis Clinical Trials

Study to Compare Oral PF-06651600, PF-06700841 and Placebo in Subjects With Moderate to Severe Ulcerative Colitis

Start date: December 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether PF-06651600 and PF-06700841 are effective in treatment of moderate to severe ulcerative colitis.

NCT ID: NCT02954159 Not yet recruiting - Ulcerative Colitis Clinical Trials

Induction of Response and Remission of Vedolizumab Monotherapy Vs Combination Therapy With Tacrolimus in Patients With Ulcerative Colitis

(COVET)
Start date: February 2017
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess if a combination therapy of tacrolimus and vedolizumab is superior to vedolizumab monotherapy for induction of remission in moderate to severe UC, and its effect on long and short-term outcomes including colectomy rate. Secondary aim of this study is to assess the safety of tacrolimus as an induction agent in patients with UC when used in combination with vedolizumab.