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Ulcerative Colitis clinical trials

View clinical trials related to Ulcerative Colitis.

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NCT ID: NCT03079700 Completed - Ulcerative Colitis Clinical Trials

Immune Modulation From Trichuris Suis

Start date: August 1, 2012
Phase: N/A
Study type: Observational

Mucosal immunology during helminth infection

NCT ID: NCT03074656 Recruiting - Clinical trials for Rheumatoid Arthritis

The Norwegian Drug Monitoring Study

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

Infliximab and other TNF-inhibitors have revolutionised the treatment of several immunological inflammatory diseases. Still, more than half of the patients either do not respond sufficiently to infliximab therapy or loose efficacy over time. The large individual variation in the serum drug concentrations on standard doses and the development of anti-drug antibodies are thought to be main reasons for these treatment failures. An individualised treatment strategy based on systematic assessments of serum drug concentrations, therapeutic drug monitoring, has been proposed as a clinical tool to optimise efficacy of infliximab treatment. Therapeutic drug monitoring seems reasonable both from a clinical and an economical point of view, but the effectiveness of this treatment strategy still remain to be shown. The NOR-DRUM study is planned as a national, randomised controlled multicentre trial in two parts aiming to assess the effectiveness of therapeutic drug monitoring in order to achieve remission in patients with immunological inflammatory diseases starting infliximab treatment (part A) and in order to maintain disease control in patients on maintenance infliximab treatment (part B). The results of the NOR-DRUM study will hopefully contribute to an implementation of a personalised medicine approach to treatment with infliximab and other biological drugs.

NCT ID: NCT03071081 Recruiting - Ulcerative Colitis Clinical Trials

Study for Safety and Tolerability of TOP1288 Administered Orally in Healthy Subjects

Start date: February 8, 2017
Phase: Phase 1
Study type: Interventional

This study evaluates the safety and tolerability of TOP1288 oral single ascending and multiple doses in healthy subjects.

NCT ID: NCT03059849 Not yet recruiting - Ulcerative Colitis Clinical Trials

Brief Escalation of Adalimumab Treatment for Prevention of Clinical Relapse in IBD

Start date: May 1, 2017
Phase: Phase 4
Study type: Interventional

To examine whether a temporary three month increase in adalimumab dosing will prevent relapse in patients with inflammatory bowel disease in clinical remission who have elevated calprotectin.

NCT ID: NCT03053713 Recruiting - Ulcerative Colitis Clinical Trials

The Effect of Diet on Disease Activity and Symptoms in Patients With Ulcerative Colitis

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

The Mediterranean Diet Pattern (MDP) has been shown to have beneficial effects on the intestinal bacteria and the immune system in diseases like cancer and diabetes. The aim of this study is to determine if a MDP will have an impact on symptoms, intestinal bacteria and the immune system in Ulcerative Colitis (UC). Symptoms, blood and stool will be examined to determine if the MDP results in changes to the intestinal bacteria or immune system.

NCT ID: NCT03051204 Not yet recruiting - Healthy Clinical Trials

OptiCal Study -Optimizing Fecal Calprotectin Monitoring: a Clinical Study Comparing CalproLab Against PhiCal and Evaluating Its Association With the Gut Microbiome

Start date: March 2017
Phase: N/A
Study type: Observational

Study Aims: To analyze stool specimens to test and validate the CalproLab assay against the predicate PhiCal in order to determine performance characteristics. And to correlate Calpro levels to the gut microbiome composition.

NCT ID: NCT03038711 Recruiting - Ulcerative Colitis Clinical Trials

A Multiple Dose Study to Assess the Safety and Tolerability of BMS-986166 in Healthy Volunteers

Start date: February 1, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to understand if multiple oral doses of BMS-986166 are safe and well tolerated in healthy patients.

NCT ID: NCT03018925 Recruiting - Ulcerative Colitis Clinical Trials

Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis

Start date: October 2016
Phase: N/A
Study type: Observational

This study aims to characterize the changes on intestinal microbiota pattern associated with the use of golimumab in order to determine if intestinal microbiota markers may correlate with golimumab therapeutic effect in patients naïve & non-naïve to anti-TNF treatment

NCT ID: NCT03016780 Recruiting - Ulcerative Colitis Clinical Trials

Fecal Microbiota Transplantation for Ulcerative Colitis

Start date: July 2016
Phase: Phase 1/Phase 2
Study type: Interventional

Ulcerative colitis is a common digestive system disease, the incidence is increasing in recent years.It is reported that the occurrence and development of ulcerative colitis is closely related to imbalance of intestinal flora .Moreover,intestinal mucosal immunity may be related to intestinal flora. Fecal microbiota transplantation as a new technology to rebuild intestinal flora has been used for several diseaseļ¼Œbut the efficacy of ulcerative colitis by fecal microbiota transplantation needs to be further explored.

NCT ID: NCT03011593 Completed - Ulcerative Colitis Clinical Trials

Effect of UGIR in Adults With Compromised Gut Function and Malabsorption

Start date: November 2015
Phase: N/A
Study type: Interventional

This study assessed the effect of a nutrition support product on quality of life in adults with compromised gut function and malabsorption.