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NCT ID: NCT03953755 Recruiting - Clinical trials for Tricuspid Regurgitation

Surgery in Secondary Tricuspid Regurgitation

STRONG
Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Currently, in cardiology/cardiosurgery the indicators for the surgical correction of secondary tricuspid regurgitationare unclear. AIM: To compare right ventricle structural and functional changes after operation in patients with secondary tricuspid regurgitation with severe mitral /aortic valve pathology, requiring surgical intervention; define the factors influencing major adverse cardiac events depending on the operation/non-operation due to moderate tricuspid regurgitation. This study intends to include 200-300 people and will occur over 5 years with an additional 3-year follow-up.

NCT ID: NCT03953183 Recruiting - Pharmacokinetics Clinical Trials

Product Use and Adaptation, Safety and Tolerability of P3P in Adult Healthy Smokers Switching to it

Start date: April 23, 2019
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the product use and adaptation in adult, current cigarette smoking subjects between baseline and after one month of use of one of two P3P variants. The effect of P3P use behavior on nicotine pharmacokinetic (PK) profile, acceptability, as well as the safety and tolerability of P3P over a period of 1 month will be investigated.

NCT ID: NCT03952559 Not yet recruiting - Atopic Dermatitis Clinical Trials

A Study of Baricitinib (LY3009104) in Children and Adolescents With Atopic Dermatitis

BREEZE-AD-PEDS
Start date: May 10, 2019
Phase: Phase 3
Study type: Interventional

The reason for this study is to see if the study drug called baricitinib works and is safe in children and teenage participants with atopic dermatitis.

NCT ID: NCT03951246 Completed - Clinical trials for Cognitive Impairment

Cognitive and Motor Training in Pediatric Posterior Fossa Tumor Survivors

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to create a rehabilitation program for children who survived posterior fossa tumors using the latest technology. Supposed that training in Fitlight, Dynavision D2, NeuroTracker will improve executive functions, visual-motor integration, fine and gross motor functions.

NCT ID: NCT03945968 Not yet recruiting - Stroke Clinical Trials

The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.

STOP RISK
Start date: July 1, 2019
Phase:
Study type: Observational

Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors for its development.

NCT ID: NCT03943147 Recruiting - Lupus Nephritis Clinical Trials

An Investigational Study to Evaluate the Safety and Effectiveness of BMS-986165 With Background Treatment in Participants With Lupus Nephritis

Start date: April 19, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of BMS-986165 compared with placebo with regard to measures of kidney function in participants with lupus nephritis (LN).

NCT ID: NCT03942159 Recruiting - Human Microbiome Clinical Trials

Modification of the Human Colon and Oral Microbiome by Allogenic HSCT

Start date: May 14, 2019
Phase:
Study type: Observational

Allogenic HSCT brings significant changes in biodiversity and composition of the gut microbiome through antibiotic usage, the mucosal damage due to the chemo- and radiotherapy toxicity; compromised oral nutritional intake and graft-versus-host disease with gut damage as the complication. Aim of the study is to investigate the composition of the microbiota in both recipient and nursing relative donor, reveal changes in biodiversity after HSCT via 3-time points V3V4 16S rRNA and NGS sequencing of the colon and oral swabs, 3-indoxyl-sulfate measurement in the urine.

NCT ID: NCT03937349 Recruiting - Clinical trials for Secondary Hyperparathyroidism

Impact of Parathyroidectomy on Cardiovascular Calcification in Dialysis-dependent Patients

Start date: May 14, 2019
Phase:
Study type: Observational

This is a prospective cohort study aimed to evaluate change of cardiovascular calcification after parathyroidectomy in patients with end-stage renal disease on dialysis compared with control group on conservative treatment.

NCT ID: NCT03934216 Recruiting - Ulcerative Colitis Clinical Trials

Safety and Efficacy of BMS-986165 in Subjects With Moderate to Severe Ulcerative Colitis (UC)

Start date: April 26, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the efficacy and safety of BMS-986165 in ulcerative colitis.

NCT ID: NCT03928158 Not yet recruiting - Heart Failure Clinical Trials

LCZ696 in Advanced LV Hypertrophy and HFpEF

Start date: May 2019
Phase: Phase 2
Study type: Interventional

Patients with advanced LVH and HFpEF will be randomly assigned in open-label fashion to receive LCZ696 titrated to 200 mg twice daily or enalapril titrated to 20 mg twice daily, and will be treated for 24 weeks.