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NCT ID: NCT00753272 Completed - Influenza Clinical Trials

Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older

Start date: September 15, 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of GlaxoSmithKline Biologicals' influenza vaccine GSK2186877A in adults 65 year of age and older. The study design is divided in two surveillance phases: one passive phase along the study during the influenza season and one active surveillance phase during the influenza peak season.

NCT ID: NCT00752219 Completed - Clinical trials for Complicated Intra-abdominal Infections

Prospective Multicenter Doubleblind Randomized Study of NXL104/Ceftazidime + Metronidazole vs. Meropenem in Treatment of Complicated Intra-abdominal Infections

Start date: March 31, 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether NXL104 plus ceftazidime is effective in the treatment of complicated intra-abdominal infections as compared to a comparator group.

NCT ID: NCT00749190 Completed - Clinical trials for Diabetes Mellitus, Type 2

BI 10773 add-on to Metformin in Patients With Type 2 Diabetes

Start date: August 2008
Phase: Phase 2
Study type: Interventional

The objective of the current study is to investigate the efficacy, safety and pharmacokinetics of five doses of BI 10773 compared to placebo given for 12 weeks as add-on therapy to on going metformin therapy in patients with T2DM with insufficient glycemic control. In addition, there will be an open-label treatment arm with sitagliptin (JanuviaTM) as add-on therapy to metformin.

NCT ID: NCT00747123 Completed - Multiple Myeloma Clinical Trials

A Safety, Tolerability and Efficacy Study of ACE-011 in Patients With Osteolytic Lesions of Multiple Myeloma

Start date: September 1, 2008
Phase: Phase 2
Study type: Interventional

Multi-center, randomized, multiple-dose study to evaluate the safety, tolerability and efficacy of ACE-011 in patients with osteolytic lesions of multiple myeloma.

NCT ID: NCT00744926 Completed - Clinical trials for Diabetes Mellitus Type 2

A Study of Taspoglutide Versus Placebo for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Diet and Exercise.

Start date: August 2008
Phase: Phase 3
Study type: Interventional

This 3 arm study will assess the efficacy, safety and tolerability of taspoglutide compared to placebo in patients with type 2 diabetes mellitus inadequately controlled with diet and exercise. Patients will be randomized to one of 3 treatment arms: taspoglutide 10mg sc once weekly, taspoglutide 20mg sc once weekly (after 4 weeks of taspoglutide 10mg sc once weekly) or placebo. After the first 24 weeks patients on placebo will be switched to taspoglutide 10mg once weekly or taspoglutide 20mg once weekly (after 4 weeks of taspoglutide 10mg once weekly). The anticipated time on study treatment is 1 year, and the target sample size is 100-500 individuals.

NCT ID: NCT00744627 Completed - Clinical trials for Generalized Anxiety Disorder

Efficacy and Safety of Vortioxetine (Lu AA21004) for Treatment of Generalized Anxiety Disorder in Adults.

Start date: September 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of vortioxetine, once daily (QD), in adults with Generalized Anxiety Disorders.

NCT ID: NCT00744497 Completed - Prostatic Neoplasms Clinical Trials

Randomized Study Comparing Docetaxel Plus Dasatinib to Docetaxel Plus Placebo in Castration-resistant Prostate Cancer

READY
Start date: October 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether survival can be prolonged in patients with castration-resistant prostate cancer who receive dasatinib with docetaxel and prednisone.

NCT ID: NCT00743925 Completed - Clinical trials for Acute Coronary Syndrome

FRANCIS-ACS Trial: A Study of the Safety and Efficacy of A 002 in Subjects With Acute Coronary Syndromes

FRANCIS-ACS
Start date: July 2008
Phase: Phase 2
Study type: Interventional

The objective of this study is to evaluate the safety and efficacy of A 002 when added to high dose atorvastatin in subjects with an acute coronary syndrome (ACS)

NCT ID: NCT00741429 Completed - Type 2 Diabetes Clinical Trials

A 2-Month Safety Follow-Up Trial

Start date: May 2007
Phase: Phase 3
Study type: Observational

The main purpose of the trial is to evaluate pulmonary function in subjects who had completed any one of the 4 MKC parent trials (MKC-TI-009, MKC-TI-102, MKC-TI-103, or MKC-TI-030) for an additional 2-month safety follow-up.

NCT ID: NCT00741338 Completed - Clinical trials for Mucopolysaccharidosis I

Immune Tolerance Study With Aldurazyme® (Laronidase)

Start date: September 2008
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to see if treatment with an antigen-specific immunosuppressive can decrease or stop an antibody response to laronidase (Aldurazyme®) during enzyme replacement therapy with laronidase in severe Mucopolysaccharidosis I (MPS I) participants.