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Influenza clinical trials

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NCT ID: NCT03367624 Recruiting - Influenza Clinical Trials

Epidemiology of Post-influenza Bacterial Pneumonia Due to a Panton-Valentine Leukocidin Positive Staphylococcus Aureus

FLUVALENTINE
Start date: October 1, 2017
Phase: N/A
Study type: Observational

Secondary bacterial influenza pneumonia caused by Panton-Valentine Leukocidin Positive Staphylococcus aureus is a rare complication but with poor prognosis. This pathology seems to affect young patients (20-40 years) without any medical history. Since the influenza pandemic of 2009, this complication is more and more mentioned, sought and diagnosed. However, the literature is poor, consisting of case reports, experimental studies on murine models, and low-power studies. The main objective is to evaluate the mortality in intensive care units of patients post-influenza bacterial pneumonia due to a Panton-Valentine Leukocidin positive Staphylococcus aureus

NCT ID: NCT03365336 Not yet recruiting - Influenza Clinical Trials

Influenza Management With Polyherbal Formulation

Start date: January 15, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to determine the efficacy of Flu care polyherbal formulation in the management of acute uncomplicated case of Influenza within 48 hours of symptoms onset.

NCT ID: NCT03345043 Active, not recruiting - Influenza Clinical Trials

Safety, Tolerability, and Immunogenicity of VAL-339851 in Healthy Adult Subjects

Start date: May 25, 2016
Phase: Phase 1
Study type: Interventional

This clinical study will assess the safety, tolerability and immunogenicity of VAL-339851 in healthy subjects.

NCT ID: NCT03344029 Recruiting - Influenza Clinical Trials

Immunogenicity and Safety of the Shenzhen Trivalent Inactivated Influenza Vaccine Versus a Trivalent Influenza Vaccine Comparator in Chinese Subjects 18 to 59 Years

Start date: November 3, 2017
Phase: Phase 4
Study type: Interventional

This was a blind-observer, monocenter, randomized, comparative, Phase IV study designed to evaluate the immunogenicity and safety of the Sanofi Pasteur Shenzhen Trivalent Influenza Vaccine (SP Shz TIV) versus the Trivalent Influenza Vaccine manufactured by Hualan Biological Engineering Inc (Hualan TIV) comparator in healthy Chinese participants aged 18 to 59 years.

NCT ID: NCT03336619 Not yet recruiting - Influenza Clinical Trials

A Phase III, Randomized, Double-Blind, Placebo Controlled Trial to Evaluate the Efficacy and Safety of Nitazoxanide in the Treatment of Uncomplicated Influenza

Start date: December 15, 2017
Phase: Phase 3
Study type: Interventional

Trial to evaluate efficacy and safety of nitazoxanide (NTZ) in the treatment of uncomplicated influenza.

NCT ID: NCT03331991 Recruiting - Influenza Clinical Trials

Prevention of Influenza and Other Wintertime Respiratory Viruses Among Healthcare Professionals in Israel

HCP
Start date: September 28, 2016
Phase: N/A
Study type: Observational

The purpose of the study on the Prevention of Influenza and Other Wintertime Respiratory Viruses among Healthcare Professionals in Israel Effectiveness of Influenza Vaccine in Preventing Influenza Virus Infection, Missed Work, and Patient Exposure: A Prospective Cohort Study of Healthcare Personnel (to be called the Healthcare Personnel or HCP study throughout this Data Security Plan) is to investigate vaccine effectiveness and respiratory illness among healthcare personnel (HCP). This will help to better understand the factors that influence influenza vaccination choice, individual vaccine response, and whether or not the influenza vaccine helps to prevent influenza in HCP.

NCT ID: NCT03330899 Not yet recruiting - Influenza Clinical Trials

Safety and Immunogencity of H7N9 Influenza Antigen With 2 Adjuvant Formulations in Healthy Adults in Brazil

Start date: January 1, 2018
Phase: Phase 1
Study type: Interventional

The overall aim of this study is to evaluate the safety, immunogenicity and dose sparing effects of H7N9 influenza antigen formulated with 2 different adjuvants .

NCT ID: NCT03328325 Not yet recruiting - Influenza Clinical Trials

Evaluation of the Effects of Age, Prior Exposure, and Previous Vaccination on B Cell Response to Influenza Vaccine in Healthy Adults and Children

Start date: December 7, 2017
Phase: Phase 4
Study type: Interventional

The study will be designed as a prospective surveillance of the immune response to seasonal influenza vaccination in 240 healthy children and adults ages 9 and over. Study duration will be 5 years, with a participant duration of 6 months. Subjects will receive Fluarix (GSK) quadrivalent inactivated influenza vaccine, at a dose of not less than 15 ug of hemagglutinin (HA), by intramuscular injection in open label fashion on day 0. Blood draws will occur at baseline, day 7, 28 and 90. The primary objective of this study is to evaluate the relationship between first influenza A virus exposure (inferred by age), vaccine history, and baseline serum antibody and Memory B cell (MBC) specificity, and the magnitude and breadth of the subsequent B cell response to seasonal influenza vaccine in healthy adults and children.

NCT ID: NCT03327987 Not yet recruiting - Influenza Clinical Trials

Early Flu Shots in SOT

Start date: November 2017
Phase: N/A
Study type: Observational

Although time from transplant has been a factor in vaccine response, there is limited data on immunizations that occur in the first post-transplant year, and there are no data that suggest influenza vaccination early post-transplant may have any adverse effects on the graft. It is suggested that early vaccinations may lead to reduced immunogenicity due to induction immunosuppression. However, not vaccinating patients may leave them vulnerable to influenza infection for a period of time. This study is designed to look at the immunogenicity and side effects of the standard of care influenza vaccine in patients between 31 and 365 days post-transplant.

NCT ID: NCT03323112 Recruiting - Influenza Clinical Trials

Immune Responses in Health Care Personnel

Start date: October 18, 2017
Phase: N/A
Study type: Observational [Patient Registry]

This is an investigator-initiated 10 year long open cohort observational study, aiming to increase the understanding of the humoral and cellular immunological mechanisms of vaccination against influenza, including effects of repeated vaccination, the duration of protection, immunity against circulating viruses, as well as factors affecting the immunological responses and immunity against other vaccine preventable infectious diseases among health care personnel. Influenza vaccination is given according to the normal routine of Hospital District of Helsinki and Uusimaa (HUS) occupational health care. Blood samples will be collected before vaccination, 5 weeks after vaccination and 6 months after vaccination. The analysis will be mainly descriptive.