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Influenza clinical trials

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NCT ID: NCT02809209 Completed - Influenza Clinical Trials

Safety of the Seasonal Trivalent Inactivated Split Virion Influenza Vaccine (IVACFLU-S)

IVACFLU-S
Start date: October 2015
Phase: Phase 1
Study type: Interventional

This is a phase I, double-blind, randomized, placebo-controlled trial with two groups of subjects to assess the safety of the seasonal trivalent inactivated split virion influenza vaccine (A/H1N1; A/H3N2 and B strains). A total of 60 healthy male and female adults, aged from 18 through 45 years will be randomized to receive the vaccine (n=30) or placebo (n=30). In addition, immune responses induced by the vaccine will be evaluated.

NCT ID: NCT02762851 Not yet recruiting - Heart Failure Clinical Trials

Influenza Vaccine To Prevent Adverse Vascular Events (RCT-IVVE)

RCT-IVVE
Start date: May 2016
Phase: Phase 4
Study type: Interventional

A multi-centre, randomized, placebo controlled, trial. Participants at high-risk for vascular events from the network of INTER- CHF will be randomized to inactivated influenza vaccine or placebo and followed prospectively over three influenza seasons. 3,500 participants will be enrolled prior to influenza season, randomized to either influenza vaccine or saline placebo, either of which they will receive annually for three years and then followed over each of the influenza seasons.

NCT ID: NCT02746211 Completed - Influenza Clinical Trials

Influenza Challenge Study in Healthy Volunteers

Start date: January 2008
Phase: Phase 1/Phase 2
Study type: Interventional

A study to determine the infectious titre of an Influenza A (H1N1) (A/New Caledonia/20/99) virus for use in other Influenza challenge studies for the development of Influenza vaccines, antiviral agents and to better understand the host response to Influenza infection.

NCT ID: NCT02743676 Completed - Influenza Clinical Trials

A Retrospective, Observational Registry of Participants With Avian Influenza Infection

Start date: January 2007
Phase: N/A
Study type: Observational

This is a global, multi-center, observational registry of participants with suspected or confirmed infection with avian influenza A H5N1. Data are collected through retrospective abstraction, from detailed case reports that may be published and available in the public domain, or as incident cases received directly from the treating physician or other medical personnel.

NCT ID: NCT02719743 Not yet recruiting - Influenza Clinical Trials

A Dose Ranging Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' GSK1557484A Vaccine in Children 6 to Less Than 36 Months of Age

Start date: May 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety and immunogenicity of different formulations of GSK Biologicals' influenza candidate vaccine GSK1557484A, in children 6-35 months of age.

NCT ID: NCT02710409 Recruiting - Influenza Clinical Trials

A Phase III Clinical Trial of An Inactivated Quadrivalent Influenza Vaccine in Healthy Subjects Aged 3 Years and Older

Start date: January 2016
Phase: Phase 3
Study type: Interventional

Influenza is an acute respiratory disease caused by influenza viruses. There are three types of the virus including A, B and C. Both type A and type B viruses can cause acute febrile respiratory tract infection, characterized by sudden fever, headache, muscle pain, cough, sore throat, nasal congestion and general malaise. The main transmission of influenza is through those highly contagious aerosol droplets containing influenza virus passed from infected people to susceptible population. Each year in the fall and winter infection of influenza is widespread in various age groups, with high incidence rate. Although influenza is generally a self-limiting disease, but in children, the elderly (especially those above 65 years old and those with chronic heart, lung, kidney, liver, blood or metabolic diseases such as diabetes or other certain diseases) and those with poor immunity function, influenza can easily lead to serious flu complications such as pneumonia, resulting in severe increase of morbidity and mortality. In order to evaluate safety and immunogenicity of a quadrivalent influenza vaccine produced by Jiangsu Jindike Biotechnology Co., Ltd. a phase III clinical trial is planned to conduct in healthy Chinese subjects aged 3 years and older.

NCT ID: NCT02691130 Recruiting - Healthy Clinical Trials

Assess the Safety and Immunogenicity of M-001 as A Standalone Influenza Vaccine and as A H5N1 Vaccine Primer in Adults

Start date: November 2015
Phase: Phase 2
Study type: Interventional

"Multimeric-001" (M-001) contains conserved, common linear influenza epitopes that activate both cellular and humoral arms of the immune system against a wide variety of influenza A and B strains. Apart from its direct action, M-001 is an attractive candidate for priming immune responses to pandemic influenza vaccine in the adult population. The current clinical study was designed to assess M-001's standalone and priming action in subjects aged 18-60 years old. This is a Phase IIb study comprising 222 participants. Eligible subjects were randomized to receive two sequential intramuscular injection of 0.5mg or 1.0mg M-001 (treatment), or two placebo (saline) injection, before receiving the sub optimal dose of H5N1 pandemic vaccine.

NCT ID: NCT02686398 Completed - Influenza Clinical Trials

Immunogenicity of a Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Undergoing Hemodialysis

Start date: October 2013
Phase: Phase 4
Study type: Interventional

During the 2013-2014 influenza season, CKD patients undergoing HD participated in the study. The patients were randomized into two groups (MF59-adjuvanted vaccine group or non-adjuvanted vaccine group) and were immunized with the respective vaccine. Sera were collected prior to vaccination and at 1and 6 months post vaccination. Levels of hemagglutination inhibition (HI) antibodies were measured.

NCT ID: NCT02677493 Active, not recruiting - Influenza Clinical Trials

Study to Evaluate the Immunogenicity and Safety of 'IL-YANG Quadrivalent Influenza Vaccine Inj.'

Start date: October 2015
Phase: Phase 3
Study type: Interventional

This study evaluates the immunogenicity and safety of 'IL-YANG Quadrivalent Influenza Vaccine Inj.' in healthy male and female adults at the age of 19 or older.

NCT ID: NCT02665871 Not yet recruiting - Influenza Clinical Trials

Safety Study of Freeze-dried Live Attenuated Influenza Vaccine for Intranasal Administration in Chinese Adults Aged 3 Years and Older

Start date: March 2016
Phase: Phase 1
Study type: Interventional

This study evaluates the safety of freeze-dried live attenuated influenza vaccine for intranasal administration in chinese adults aged 3 years and older.80 subjects will be divided into 2 groups, including 18 years and older and 3-17 years old. Subjects in each groups will randomly receive one dose of influenza vaccine or placebo in a 3:1 ratio.