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NCT ID: NCT00633893 Completed - Venous Thrombosis Clinical Trials

Efficacy and Safety Study of Apixaban for Extended Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Start date: May 2008
Phase: Phase 3
Study type: Interventional

The purpose is to evaluate the effects of an investigational blood thinner, apixaban, in preventing venous thromboembolic (VTE) recurrence or death in patients who have completed their intended treatment for deep vein thrombosis (DVT) or pulmonary embolism (PE)

NCT ID: NCT00625898 Terminated - Breast Cancer Clinical Trials

BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab

BETH
Start date: April 2008
Phase: Phase 3
Study type: Interventional

The trial will determine the value of adding bevacizumab to chemotherapy plus trastuzumab in patients with resected node-positive or high risk node-negative, HER2-positive breast cancer.

NCT ID: NCT00624338 Completed - Clinical trials for Lupus Erythematosus, Systemic

Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE)

APRIL-SLE
Start date: January 2008
Phase: Phase 2/Phase 3
Study type: Interventional

This study is to evaluate the efficacy and safety of atacicept compared to placebo in preventing new flares in subjects with systemic lupus erythematosus (SLE) and to confirm the optimal dose of atacicept for treatment of subjects with SLE and gain information on the effect of atacicept on markers specific to its mechanism of action (MoA) and their correlation to disease activity/progression. Study medication will be administered through subcutaneous (under the skin) injections, beginning with twice weekly injections for the first 4 weeks, followed by once weekly doses for 48 weeks. Following the last treatment, a safety follow-up period of 24 weeks will be conducted.

NCT ID: NCT00622648 Completed - Acute Illness Clinical Trials

Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin

LIFENOX
Start date: January 2008
Phase: Phase 4
Study type: Interventional

The primary objective: - To demonstrate in patients hospitalized for an acute medical illness that enoxaparin with Graduated Elastic Stockings is superior to enoxaparin-placebo with Graduated Elastic Stockings on overall mortality at day 30 after randomization. The secondary objective: - To compare, in patients hospitalized for an acute medical illness, enoxaparin with Graduated Elastic Stockings versus enoxaparin placebo with Graduated Elastic Stockings on overall mortality at day 90 after randomization. - To evaluate the safety of enoxaparin VTE prophylaxis in patients hospitalized for acute medical illness with respect to major hemorrhage, total bleedings, heparin induced thrombocytopenia, adverse events and serious adverse events .

NCT ID: NCT00622323 Completed - Clinical trials for Type 2 Diabetes Mellitus

Post Marketing Surveillance Study of Byetta ™ (Exenatide) Use Among Filipino Patients

Start date: February 2008
Phase: N/A
Study type: Observational

This is a prospective, non-interventional, post marketing surveillance study to determine the proportion of patients experiencing an adverse event and a list of the experienced adverse events, serious and non-serious, that would occur among Filipino patients with type 2 diabetes mellitus who are treated with exenatide who are taking metformin, a sulfonylurea or a combination of metformin and a sulfonylurea but have not achieved adequate glycemic control.

NCT ID: NCT00622245 Terminated - Clinical trials for Depression in Patients With Bipolar Disorder

Efficacy and Safety of Lu AA34893 in Patients With Bipolar Depression

Start date: January 2008
Phase: Phase 2
Study type: Interventional

This study will evaluate the efficacy and safety of different doses of Lu AA34893 in the treatment of depression in patients with bipolar disorder.

NCT ID: NCT00621322 Completed - Tuberculosis Clinical Trials

Safety and Immunogenicity Study of GSK Biologicals Tuberculosis Vaccines (692342) to Healthy Adults

Start date: April 3, 2008
Phase: Phase 2
Study type: Interventional

This observer blind study will assess the safety and immunogenicity of different formulations of GSK Biologicals' 692342 tuberculosis vaccine in healthy adults aged 18 to 45 years with a positive PPD skin test. The Protocol Posting has been updated in order to comply with the FDA Amendment Act, Sep 2007.

NCT ID: NCT00617981 Completed - Clinical trials for Hepatocellular Carcinoma

Phase 3 Study of ThermoDox With Radiofrequency Ablation (RFA) in Treatment of Hepatocellular Carcinoma (HCC)

Start date: May 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether ThermoDox, a thermally sensitive liposomal doxorubicin, is effective in the treatment of non-resectable hepatocellular carcinoma when used in conjunction with radiofrequency ablation (RFA).

NCT ID: NCT00615433 Completed - Schizophrenia Clinical Trials

Lurasidone HCl A Phase 3 Study of Patients With Acute Schizophrenia

Start date: January 2008
Phase: Phase 3
Study type: Interventional

Lurasidone HCl is a compound developed for the treatment of schizophrenia. This clinical study is designed to test the hypothesis that lurasidone is more efficacious than placebo. The study will also evaluate the safety and tolerability of lurasidone as compared to placebo.

NCT ID: NCT00614380 Completed - Hypertension Clinical Trials

Open Label Study Telmisartan and Amlodipine in Hypertension

Start date: January 2008
Phase: Phase 3
Study type: Interventional

The primary objective of this trial is to assess the efficacy and safety of the fixed dose combinations telmisartan 40 mg / amlodipine 5 mg (T40/A5) or telmisartan 80 mg / amlodipine 5 mg (T80/A5) during long-term open-label treatment.