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Venous Thrombosis clinical trials

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NCT ID: NCT03945045 Recruiting - Venous Thrombosis Clinical Trials

A Study of the IJV or the SCV Approach for Ultrasound-guided Implantation of TIVAD

Start date: May 21, 2019
Phase: N/A
Study type: Interventional

To compare IJV and SCV as the implantation site of TIVAD and its associated thrombotic or occlusion rate, our study plans to enroll 240 patients with cancer who require central line TIVADs and randomizes them with 1:1 ratio to receive the TIVAD implantation at SCV or IJV. After the implantation, the patients will be regularly followed through phone contact and chart review for 2 years, and any symptomatic thrombosis or occlusion will be found during chemotherapy injection or regular push-pull heparin saline flush every 6 weeks as our hospital care protocol. To detect any asymptomatic thrombosis, the patients will also receive screening vascular ultrasound at 2 weeks, 2 months, and 6 months postoperatively. The study primary endpoints include any infection, asymptomatic thrombosis found by screen ultrasound, and clinically symptomatic thrombosis or occlusion and major mechanical failure/dislocation of TIVAD.

NCT ID: NCT03937947 Recruiting - Clinical trials for Traumatic Brain Injury

Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study

TARDIS
Start date: May 2019
Phase:
Study type: Observational

Whilst deep vein thrombosis (DVT) is common following traumatic brain injury (TBI), optimal timing and safety of pharmacological prophylaxis is uncertain. Paradoxically the harm associated with the occurrence of is also unclear. This study is an observational pilot that aims to define the incidence of proximal DVT in patients with moderate to severe TBI. It seeks prospectively to determine if there is an association between DVT and outcome. It also seeks to explore possible associations between the occurrence of DVT and the incidence of lung injury and/or ventilator associated pneumonia.

NCT ID: NCT03937583 Not yet recruiting - Pulmonary Embolism Clinical Trials

Screening for Cancer in Patients With Thromboembolic Disease

PEETAC
Start date: June 1, 2019
Phase: Phase 2
Study type: Interventional

Multicenter, randomized (1:1) and open clinical trial comparing limited screening with extended screening with the performance of PET-CT (Positron emission tomography-computed tomography) in the search for neoplasms in patients with unprovoked venous thromboembolic disease at high risk of developing cancer at follow-up.

NCT ID: NCT03919305 Not yet recruiting - Clinical trials for Cerebral Venous Sinus Thrombosis

Cerebral Venous Thrombosis Cohort Study in China Mainland

CCC
Start date: June 1, 2019
Phase:
Study type: Observational

This study was aimed to reveal the clinical features,natural history of the diseases and current therapeutic situations of cerebral venous thrombosis (CVT) in China mainland. Blood samples and cerebrospinal fluid samples will be collected after recruitment to reveal the pathological mechanisms of CVT and identify the biomarkers for CVT.

NCT ID: NCT03911661 Recruiting - Atrial Fibrillation Clinical Trials

Fearon Algorithm in Warfarin Patient Self-Management

Start date: November 20, 2018
Phase: N/A
Study type: Interventional

This study aims to explore the feasibility of a novel, patient-specific algorithm for adjusting warfarin doses during chronic anticoagulation therapy. Specifically investigators are interested in determining whether patients can use this algorithm to assume responsibility for managing their own warfarin therapy including making independent decisions about their warfarin dose and when to retest their next international normalized ratio (INR) test based on the result of their current INR result obtained using a point-of-care INR monitor.

NCT ID: NCT03909399 Recruiting - Pulmonary Embolism Clinical Trials

Prevention and Prophylaxis of Cancer Associated Thrombosis in High Risk Oncology Patients

Start date: January 25, 2019
Phase:
Study type: Observational

Prevention and Prophylaxis (Thromboprophylaxis - ACT) of Cancer Associated Thrombosis (CAT) in High Risk Oncology Patients: ACT4CAT.

NCT ID: NCT03908866 Recruiting - Infection Clinical Trials

Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurosurgical Intensive Care Unit

PICINI
Start date: April 1, 2019
Phase: N/A
Study type: Interventional

This study aim to compare the cost-effectiveness and safety between centrally and peripherally inserted central venous catheters in neurosurgical intensive care unit patients.

NCT ID: NCT03902678 Recruiting - Clinical trials for Portal Vein Thrombosis

Role of EUS Guided FNA of Portal Vein Thrombus in the Diagnosis and Staging of Hepatocellular Carcinoma

Start date: May 11, 2017
Phase: N/A
Study type: Interventional

Since not every portal vein thrombus (PVT) in a patient with hepatocellular carcinoma (HCC) is a tumor thrombus, since the nature of the thrombus will ultimately determine the course of treatment, and since PVT may be even the initial sign of an undetected HCC, every effort should be made to distinguish between a tumor and a non-tumor PVT. In addition, malignant PVT does not always demonstrate neovascularity and/or enhancement, which makes fine needle aspiration (FNA) necessary in order to characterize the nature of the PVT. Sampling of portal vein thrombus with trans-abdominal ultrasound guidance may lead to erroneous results because of inadvertent inclusion of normal hepatocytes or associated liver masses. Further, potential adverse events of trans-abdominal portal vein sampling include serious biliary and/or vascular injury. In contrast to the percutaneous approach, Endoscopic ultrasound (EUS) provides a unique view and access to the main portal vein. From the duodenal bulb and second part of the duodenum, the portal vein can be visualized from the confluence of the splenic and superior mesenteric veins into the porta hepatis. Periportal collateral vessels or cavernous transformation of the portal vein, which commonly are associated with portal vein thrombosis, are also easily and reliably detected by EUS instruments with color Doppler US capability. With a linear-array echo-endoscope, the portal vein can be punctured easily with a fine needle under direct visualization, while avoiding the adjacent hepatic artery, bile duct, and collateral vessels (if present). Because the approach is not trans-hepatic, it eliminates any need to avoid the primary tumor and any possibility of contaminating the specimen with hepatocytes, as can occur if the needle tracks through the liver parenchyma. Thus, the rate of false-positive diagnoses is likely to be lower with the EUS compared with the percutaneous approach

NCT ID: NCT03901872 Recruiting - Clinical trials for Deep Vein Thrombosis

Contemporary Endovascular Therapies in Treatment of Acute Iliofemoral DVT A Prospective, Multicentre Cohort Trial

CLEAR-DVT
Start date: March 29, 2019
Phase:
Study type: Observational

The goal of this initial proof of principle single arm cohort trial is to determine if contemporary endovascular venous intervention, compared with a 1:1 propensity-matched medical therapy arm of the ATTRACT trial, significantly reduces the 2-year occurrence of PTS in subjects with symptomatic proximal DVT.

NCT ID: NCT03895502 Not yet recruiting - Neoplasms Clinical Trials

Optimal Duration of Anticoagulation Therapy for Isolated Distal Deep Vein Thrombosis in Patients With Cancer Study

ONCO DVT
Start date: April 1, 2019
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine the optimal duration of anticoagulation therapy (3 months versus 12 months) with direct oral anticoagulant (edoxaban) for isolated distal deep vein thrombosis.