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NCT ID: NCT02338843 Completed - Sepsis Clinical Trials

A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension

ATHOS-3
Start date: March 2015
Phase: Phase 3
Study type: Interventional

This is a Phase 3, double-blind, randomized study of LJPC-501 (angiotensin II) in adult patients diagnosed with catecholamine-resistant hypotension (CRH) conducted in multiple centers globally.

NCT ID: NCT02338245 Completed - Clinical trials for Metastatic Breast Cancer

Study of ASLAN001 in Combination With Capecitabine in MBC That Has Failed on Prior Trastuzumab

Start date: December 29, 2014
Phase: Phase 2
Study type: Interventional

This is an open-label, randomized, parallel group Phase 2A/2B study to evaluate the clinical activity of ASLAN001 in combination with capecitabine compared with lapatinib in combination with capecitabine in patients with HER2 positive metastatic breast cancer that has failed on prior trastuzumab therapy.

NCT ID: NCT02336685 Completed - Pain Clinical Trials

Study of Efficacy, Safety of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3001

Start date: July 7, 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as adjunctive therapy compared with placebo in participants with chronic moderate to severe pain and functional impairment from knee or hip osteoarthritis that is not adequately controlled by current pain therapy.

NCT ID: NCT02335788 Completed - Clinical trials for Peripheral Embolization

EMBA Peripheral Embolization Device ("EPED") Study

EPED
Start date: February 2015
Phase: N/A
Study type: Interventional

This is an open label, acute, non-randomized, prospective, "first in man" (FIM) single-center study of the EMBA Medical Peripheral Embolization Device (PED).

NCT ID: NCT02326233 Completed - Healthy Clinical Trials

Pharmacokinetics, Safety, and Tolerability Study of the Pen and PFS of SB5 in Healthy Subjects

Start date: June 2015
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the pharmacokinetics, safety, and tolerability of the pre-filled pen and pre-filled syringe of SB5 in healthy subjects.

NCT ID: NCT02325830 Completed - Heart Failure Clinical Trials

CARILLON Mitral Contour System® for Reducing Functional Mitral Regurgitation

REDUCE FMR
Start date: March 2015
Phase: N/A
Study type: Interventional

The objective of this prospective, multi-center, randomized, double-blind trial is to assess the safety and efficacy of the CARILLON Mitral Contour System in treating functional mitral regurgitation (FMR) associated with heart failure, compared to a randomized Control group which is medically managed according to heart failure guidelines.

NCT ID: NCT02325791 Completed - Clinical trials for Respiratory Syncytial Virus Infections

Study to Evaluate the Efficacy and Safety of Suptavumab (REGN2222) for the Prevention of Medically Attended RSV (Respiratory Syncytial Virus) Infection in Preterm Infants

Start date: July 21, 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study was to evaluate the efficacy, safety, pharmacokinetics (PK), and immunogenicity of suptavumab (REGN2222) in infants born no more than 35 weeks, 6 days gestational age who are no more than 6 months of age at the time of enrollment in their respective geographic location. In order to optimize the potential benefit in this vulnerable population, we conducted this study during the RSV season using dosing regimens that are expected to be effective.

NCT ID: NCT02323035 Completed - Clinical trials for Obstructive Sleep Apnea

Investigative Headgear With CPAP Mask

Start date: December 2014
Phase: N/A
Study type: Interventional

This investigation is designed to evaluate the at-home usability, performance, user acceptance and reliability of the Headgear with a CPAP Mask for a duration of 2-4 weeks.

NCT ID: NCT02316886 Completed - Clinical trials for Coronary Artery Disease

Preventive PCI or Medical Therapy Alone for Vulnerable Atherosclerotic Coronary Plaque

PREVENT
Start date: October 5, 2015
Phase: Phase 4
Study type: Interventional

The primary aim of the trial is to determine whether preventive PCI with bioabsorbable vascular scaffolds (BVS) (early period) or everolimus-eluting stents (middle and late period) plus optimal medical therapy (OMT) on functionally insignificant (FFR > 0.80) vulnerable coronary plaque, as determined by intracoronary imaging, would result in a significant reduction of the primary composite outcome of death from cardiac causes, target-vessel myocardial infarction (MI), target-vessel revascularization (TVR), and hospitalization for unstable or progressive angina at 2 years, when compared with OMT alone.

NCT ID: NCT02306746 Completed - Critical Illness Clinical Trials

The Augmented Versus Routine Approach to Giving Energy Trial

TARGET
Start date: June 16, 2016
Phase: Phase 3
Study type: Interventional

Nutrition therapy is an essential standard of care for all critically ill patients who are mechanically ventilated and remain in the intensive care unit for more than a few days. The investigators plan to conduct a 4,000 patient, double-blind, randomised controlled trial to determine if augmentation of calorie delivery using energy dense enteral nutrition in mechanically ventilated patients improves 90 day survival when compared to routine care.