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Obstructive Sleep Apnea clinical trials

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NCT ID: NCT03736382 Recruiting - Clinical trials for Obstructive Sleep Apnea

Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea

Start date: November 2018
Phase: N/A
Study type: Interventional

Mild intermittent hypoxia (IH) initiates sustained increases in chest wall and upper airway muscle activity in humans. This sustained increase is a form of respiratory plasticity known as long-term facilitation (LTF). Repeated daily exposure to mild IH that leads to the initiation of LTF of upper airway muscle activity could lead to increased stability of the upper airway. In line with PI's laboratory's mandate to develop innovative therapies to treat sleep apnea, this increased stability could ultimately reduce the continuous positive airway pressure (CPAP) required to treat obstructive sleep apnea (OSA) and improve compliance with this gold standard treatment. Improved compliance could ultimately serve to mitigate those comorbidities linked to sleep apnea. Moreover, in addition to improving CPAP compliance numerous studies indicate that mild IH has many direct beneficial effects on cardiovascular, neurocognitive and metabolic function. Thus, mild IH could serve as a multipronged therapeutic approach to treat sleep apnea. In accordance with this postulation, our proposal will determine if repeated daily exposure to mild IH serves as an adjunct therapy coupled with CPAP to mitigate associated co-morbidities via its direct effects on a variety of cardiovascular, metabolic and neurocognitive measures and indirectly by improving CPAP compliance. Modifications in autonomic (i.e. sympathetic nervous system activity) and cardiovascular (i.e. blood pressure) function will be the primary outcome measures coupled to secondary measures of metabolic and neurocognitive outcomes.

NCT ID: NCT03726346 Recruiting - Clinical trials for Obstructive Sleep Apnea

The Evaluation of a Mask for the Treatment of Obstructive Sleep Apnea

Start date: November 2018
Phase: N/A
Study type: Interventional

This investigation is a prospective, non randomized, non blinded study. This investigation is designed to evaluate the performance, comfort and ease of use with the F&P trial mask amongst Obstructive Sleep Apnea (OSA) patients. Up to 45 OSA patients will be recruited from the Pulmonary Disease Specialists Research database

NCT ID: NCT03725956 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Polysomnographic Findings in Nasal Polyposis

POLYSOMNO
Start date: December 2018
Phase: N/A
Study type: Interventional

Nasal polyposis (NP) is a chronic inflammatory disease of the nasal and sinus mucosa leading to protrusion of edematous polyps in the nasal cavity. Prevalence of NP among the chronic rhinosinusitis patients is 25-30 %. NP leads to significant limitations in physical, emotional and social aspects of life of the affected patients. Sleep disorder is frequently reported by those patients with impaired nasal breathing. Till now few studies have objectively assessed the impact of NP on sleep quality. the objectives are to figure out sleep disturbances in NP and to analyze the outcomes of sinus surgery on sleep recovering.

NCT ID: NCT03725839 Recruiting - Clinical trials for Obstructive Sleep Apnea

The Evaluation of an Interface for the Treatment of Obstructive Sleep Apnea (OSA)

Start date: November 5, 2018
Phase: N/A
Study type: Interventional

This investigation is designed to evaluate the performance as well as the patients overall acceptance of the interface.

NCT ID: NCT03718858 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

The Impact of Interscalene Block on Obstructive Sleep Apnea

Start date: November 2018
Phase: N/A
Study type: Interventional

This study is a randomized controlled trial to evaluating the impact of interscalene block on worsening of obstructive sleep apnea in patients undergoing ambulatory shoulder surgery.

NCT ID: NCT03716648 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Titration of Oral Appliance Therapy: a Prospective, Randomized Cross-over Trial.

Start date: November 2018
Phase: N/A
Study type: Interventional

In this prospective randomized cross-over trial, 3 different titration procedures will be compared: 1. titration of the mandibular advancement device (MAD) in the home setting based on both the physical limits of the patient's mandibular protrusion and the resolution of subjective complaints, as currently often used in routine clinical practice; 2. an overnight titration PSG using the remotely controlled mandibular positioner (RCMP) with stepwise mandibular protrusion until respiratory events are reduced and 3. incremental protrusion of the mandible during DISE using the RCMP until upper airway collapse at all collapsible levels is eliminated. The aim of this study is to prospectively compare the target protrusion, as well as the treatment outcome in terms of treatment efficacy, of the 3 different titration protocols.

NCT ID: NCT03705780 Active, not recruiting - Clinical trials for Obstructive Sleep Apnea

Fentanyl Test and A Short OSAS Screening Scale for Severe Obstructive Sleep Apnea

Start date: June 21, 2018
Phase: N/A
Study type: Interventional

The aim of this study was to estimate and compare the value of the preoperative fentanyl test and the short OSAS screening scale to diagnose severe obstructive sleep apnea´╝Ťand to observe the required amount of hydromorphone and the adverse respiratory events after adenotonsillectomy.

NCT ID: NCT03695315 Not yet recruiting - Insulin Resistance Clinical Trials

Tissue-specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia

Start date: October 2018
Phase:
Study type: Observational

Obstructive sleep apnea (OSA) is a common condition associated with significant adverse health outcomes. Our overarching hypothesis is that patients with OSA and hypoxia (H-OSA) have greater degrees of insulin resistance in both liver and adipose tissue when compared to those without hypoxia (NH-OSA) thus leading to increased risk for the development of diabetes in the former group.

NCT ID: NCT03679611 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications

Sugammadex
Start date: September 17, 2018
Phase: Phase 4
Study type: Interventional

Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs. This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine resulting in faster discharge from the operating room (OR) in obese patients with OSA undergoing bariatric surgery. Half of the patients in the study will receive sugammadex and the other half of the patients will receive neostigmine.

NCT ID: NCT03647462 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized COPD Patients

COPD Readmit
Start date: September 23, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether early diagnosis of OSA and initiation of and adherence to CPAP therapy in patients hospitalized for chronic obstructive pulmonary disease reduce 30-day hospital readmission rates.