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NCT ID: NCT03305016 Not yet recruiting - Clinical trials for Endocrine System Diseases

A Safety, Tolerability and Efficacy Study of TransCon hGH in Children With Growth Hormone Deficiency

Start date: November 2017
Phase: Phase 3
Study type: Interventional

A 26 week trial of TransCon hGH, a long-acting growth hormone product, administered once-a-week. Approximately 150 children (males and females) with growth hormone deficiency (GHD) will be included. All study participants will receive TransCon hGH. This is a global trial that will be conducted in, but not limited to, the United States, Canada, Australia, and New Zealand.

NCT ID: NCT03291288 Not yet recruiting - Clinical trials for Drug Interaction Potential

Pexidartinib Effects on How the Body Processes Midazolam and S-warfarin (Pharmacokinetics)

Start date: November 2017
Phase: Phase 1
Study type: Interventional

This study has two parts. Part 1 will test how pexidartinib affects the way the body processes midazolam and S-warfarin Part 2 will test the efficacy and safety of pexidartinib treatment in various tumor types. In Part 2, the same participants will continue to receive pexidartinib twice daily, at a dose specific to their tumor type. Participants will be allowed to continue using pexidartinib as long as the participant derives benefit.

NCT ID: NCT03285620 Recruiting - Hepatitis B Clinical Trials

A Study of AL-034 to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses in Healthy Subjects

Start date: September 7, 2017
Phase: Phase 1
Study type: Interventional

This is a Phase 1 first-in-human (FIH) study evaluating single and multiple dose administration of AL-034 in healthy adult subjects. The aim is to examine the safety (including pharmacodynamic [PD] biomarker assessments), tolerability, and pharmacokinetics (PK) of increasing single ascending doses (SADs) (Part 1) and multiple ascending doses (MADs) (Part 2) of AL-034. The potential food effect will be investigated in healthy adult subjects at one or optionally 2 single dose level(s).

NCT ID: NCT03273153 Recruiting - Clinical trials for Advanced BRAFV600 Wild-type Melanoma

A Study of Cobimetinib Plus Atezolizumab Versus Pembrolizumab in Participants With Previously Untreated Advanced BRAFv600 Wild-Type Melanoma

Start date: October 30, 2017
Phase: Phase 3
Study type: Interventional

This is a Phase III, multicenter, open-label, randomized study designed to evaluate the efficacy, safety, and pharmacokinetics of cobimetinib plus atezolizumab compared with pembrolizumab in treatment-naive participants with advanced BRAFV600 wild-type melanoma.

NCT ID: NCT03255499 Recruiting - Cognitive Change Clinical Trials

Efficacy of the MovinCog Intervention in Children

Start date: September 10, 2017
Phase: N/A
Study type: Interventional

This study aims to test the efficacy of the MovinCog Intervention to enhance cognitive abilities in children 7-15 yrs. The intervention consists of two parts: a physical exercise regimen, based on high-intensity training, and a cognitive training component. The design will contrast the intervention with an active control group, matched for expectancy effects.

NCT ID: NCT03254368 Recruiting - Clinical trials for Type 2 Diabetes Mellitus

Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes

Start date: September 12, 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of the study drug ZGN-1061 in participants with type 2 diabetes.

NCT ID: NCT03254160 Recruiting - Ischemic Stroke Clinical Trials

DNS-3379 vs. Placebo in Stroke Rehabilitation

SPIRIT
Start date: October 30, 2017
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled parallel group outpatient 42-day treatment study that will utilize standard stroke rehabilitation outcome measures to evaluate the effect of DNS-3379 on upper extremity motor recovery in subjects following ischemic stroke.

NCT ID: NCT03251339 Recruiting - Healthy Clinical Trials

Safety and Immunogenicity of MSB11455 in Healthy Subjects

Start date: August 21, 2017
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to compare the immunogenicity and safety of MSB11455 and Neulasta in healthy adult subjects.

NCT ID: NCT03247907 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Humidification Needs

Start date: September 2017
Phase: N/A
Study type: Interventional

A study undertaken to investigate mouth leak for airway discomfort/dryness while using CPAP. This study will also measure how much humidification is required to treat subsequent upper airway discomfort/dryness from mouth leak by utilizing different levels and types of humidification.

NCT ID: NCT03233360 Recruiting - Clinical trials for Hepatocellular Carcinoma

Hepatocellular Carcinoma Registry in Asia

Start date: April 17, 2017
Phase: N/A
Study type: Observational

This registry is designed as a multi-centre longitudinal cohort study of patients diagnosed with HCC between 1st January 2013 and 30th June 2018 in nine countries (ie, Korea, Taiwan, Thailand, Japan, China, Hong Kong, Australia, New Zealand and Singapore). Approximately 30% of the sample size will be identified retrospectively and 70% will be identified prospectively from the start date of the registry (October 2016), with an even distribution of consecutively diagnosed patients within the different years.