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NCT ID: NCT00261976 Completed - Psoriasis Clinical Trials

A Long-term Safety Study of Infliximab (Remicade)

Start date: February 2002
Phase: Phase 4
Study type: Observational

This is a study evaluating the long-term safety of infliximab (Remicade)

NCT ID: NCT00261950 Completed - Clinical trials for Secondary Hyperparathyroidism

Bone Biopsy Study For Dialysis Patients With Secondary Hyperparathyroidism of End Stage Renal Disease

BONAFIDE
Start date: May 2006
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effects of cinacalcet on markers of bone turnover in patients with kidney disease who are receiving dialysis.

NCT ID: NCT00261846 Completed - Clinical trials for Chronic Myeloid Leukemia

Study Evaluating SKI-606 (Bosutinib) In Philadelphia Chromosome Positive Leukemias

Start date: March 2006
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open-label, continuous daily dosing, two-part safety and efficacy study of SKI-606 (bosutinib) in Philadelphia chromosome positive leukemias (Ph+). Part 1 is a dose-escalation study in chronic phase Chronic Myelogenous Leukemia (CML) subjects to establish the maximum tolerated dose (MTD) in this subject population. Part 2 has begun after the completion of Part 1 and after a dose has been established for the compound in chronic phase subjects. Part 2 is a study of the the efficacy of 500mg daily oral SKI-606 (bosutinib) in patients with all phases of Ph+ CML and Ph+ Acute Lymphocytic Leukemia (ALL). The protocol will test the hypotheses that oral daily dosing of bosutinib at 500 mg will attain (1) Major Cytogenetic Response (MCyR) in chronic phase CML patients and (2) Overall Hematological Response (OHR) in advanced leukemia patients. Each phase of the disease will be evaluated as a separate cohort.

NCT ID: NCT00260832 Completed - Clinical trials for Acute Myeloid Leukemia

Trial of Decitabine in Patients With Acute Myeloid Leukemia

Start date: November 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the results in older patients who have newly diagnosed or secondary acute myeloid leukemia (AML) and who are to either receive decitabine or patient's choice with the physician's advice of either cytarabine or supportive care medication.

NCT ID: NCT00259922 Completed - Constipation Clinical Trials

Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain

Start date: August 2005
Phase: Phase 3
Study type: Interventional

Adults who are taking opioid therapy for persistent non-cancer pain and have resulting opioid-induced bowel dysfunction (OBD) will be randomized (1:1:1) to one of 2 alvimopan arms, or to placebo. The primary objective of this phase 3 confirmatory study is to compare alvimopan with placebo for efficacy in the treatment of OBD. The primary efficacy endpoint is based on frequency of bowel movements. Subjects will be required to: (1) track their bowel movements and other bowel symptoms and (2) attend 6 clinic visits over 4 months.

NCT ID: NCT00259428 Completed - Atrial Fibrillation Clinical Trials

EURopean Trial In Atrial Fibrillation(AF) or Flutter (AFL) Patients Receiving Dronedarone for the maIntenance of Sinus Rhythm (EURIDIS)

EURIDIS
Start date: November 2001
Phase: Phase 3
Study type: Interventional

To assess the efficacy of dronedarone versus placebo for the maintenance of normal sinus rhythm after electrical, pharmacological or spontaneous conversion of atrial fibrillation/atrial flutter (AF/AFL). To assess the efficacy of dronedarone versus placebo on AF/AFL-related symptoms. To assess the efficacy of dronedarone versus placebo on ventricular rate control in case of AF/AFL recurrence.

NCT ID: NCT00257972 Completed - Bipolar Disorder Clinical Trials

Study of Aripiprazole in Patients With Bipolar I Disorder

Start date: October 2004
Phase: Phase 3
Study type: Interventional

The purpose of this research study is to compare the efficacy of aripiprazole with placebo in combination with lithium or valproate monotherapy, in the treatment of bipolar I patients with manic or mixed episodes.

NCT ID: NCT00257257 Completed - Clinical trials for Type 2 Diabetes Mellitus

Study Evaluating Rimonabant Efficacy in Drug-NAive DiabEtic Patients

SERENADE
Start date: March 2005
Phase: Phase 3
Study type: Interventional

Primary: Effect on HbA1c over 6 months in drug-naive patients with type 2 diabetes Secondary: Effect on glucose, insulin, C-peptide, insulin resistance, body weight, HDL-cholesterol, triglycerides, blood pressure - Safety, tolerability

NCT ID: NCT00256750 Completed - Clinical trials for Kidney Transplantation

Belatacept Evaluation of Nephroprotection and Efficacy as First-line Immunosuppression (BENEFIT)

BENEFIT
Start date: March 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to learn if Belatacept can provide protection from organ rejection following kidney transplantation while avoiding some of the toxic effects of standard immunosuppressive medications such as kidney damage. Effects on kidney function and patient survival as well as drug safety will also be studied.

NCT ID: NCT00255463 Completed - Breast Cancer Clinical Trials

Phase II Neoadjuvant ER+/PgR + Arimidex +/- Iressa Study

Start date: January 2004
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare the changes in a proliferation biomarker in subjects receiving Anastrozole or Anastrozole/ZD1839 combination.