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NCT ID: NCT00266877 Completed - Clinical trials for Carcinoma, Non-Small-Cell Lung

Study Evaluating the Safety Of HKI-272 (Neratinib) In Subjects With Advanced Non-Small Cell Lung Cancer

Start date: December 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study is to learn whether HKI-272 is safe and effective in treating non-small cell lung cancer.

NCT ID: NCT00266240 Completed - Clinical trials for Diabetes Mellitus Type 2

A Study of GK Activator (2) in Patients With Type 2 Diabetes Mellitus

Start date: November 2005
Phase: Phase 2
Study type: Interventional

This study will evaluate the efficacy, safety, tolerability, and pharmacokinetics of oral GK Activator (2), compared to placebo, in patients with type 2 diabetes mellitus. The anticipated time on study treatment is less than 3 months, and the target sample size is 100-500 individuals.

NCT ID: NCT00265317 Completed - Clinical trials for Carcinoma, Non-Small-Cell Lung

A Study In Patients With Non-Small Cell Lung Cancer Testing If Erlotinib Plus SU011248 (Sunitinib) Is Better Than Erlotinib Alone

SUN1058
Start date: June 2006
Phase: Phase 2
Study type: Interventional

This study will test whether treatment with erlotinib plus SU011248 is better than erlotinib alone in patients with advanced/metastatic lung cancer who have received previous treatment with a platinum-based regimen

NCT ID: NCT00264927 Completed - Hyponatremia Clinical Trials

Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion

SIADH
Start date: May 2004
Phase: Phase 3
Study type: Interventional

To assess the efficacy of SR121463B in correcting hyponatremia in patients with syndrome of inappropriate antidiuretic secretion (SIADH).To assess the long-term efficacy of SR121463B in maintaining normal levels of serum sodium in patients with SIADH. To assess the safety and tolerability of SR121463B in patients with SIADH. The double blind period is followed by an open label extension study with flexible doses of satavaptan.

NCT ID: NCT00264914 Completed - Hyponatremia Clinical Trials

Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion

SIADH Safety
Start date: July 2005
Phase: Phase 3
Study type: Interventional

To determine the long-term safety and tolerability of SR121463B in patients with syndrome of inappropriate antidiuretic secretion (SIADH). To assess the long-term efficacy of SR121463B in maintaining normal levels of serum sodium in patients with SIADH. Long term safety is evaluated further in an open label extension study with flexible doses of satavaptan.

NCT ID: NCT00264849 Completed - Asthma Clinical Trials

Omalizumab in Adult and Adolescent Patients With Severe Persistent Allergic Asthma

Start date: November 2005
Phase: Phase 4
Study type: Interventional

Omalizumab will be given as add-on treatment to optimized asthma therapy in patients with severe persistent asthma, who demonstrate inadequate asthma symptom control. Response to omalizumab over time will be assessed by physicians and patients evaluating the overall improvement in control of their asthma. THIS STUDY IS NOT ENROLLING PATIENTS IN THE US.

NCT ID: NCT00264550 Completed - Clinical trials for Rheumatoid Arthritis

An Efficacy and Safety Study of Golimumab in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy

GO-FORWARD
Start date: December 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of golimumab, alone or in combination with methotrexate (MTX), as compared to methotrexate alone in rheumatoid arthritis (RA) patients who have active rheumatoid arthritis despite treatment with MTX.

NCT ID: NCT00264537 Completed - Clinical trials for Rheumatoid Arthritis

A Study of the Safety and Efficacy of Golimumab in Subjects With Rheumatoid Arthritis That Are Methotrexate-naive

Start date: December 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of golimumab, alone or in combination with methotrexate, as compared to methotrexate alone in rheumatoid arthritis subjects who have not been previously treated with methotrexate.

NCT ID: NCT00263341 Completed - Contraception Clinical Trials

Safety and Efficacy of a Contraceptive Vaginal Ring Delivering Nestorone® and Ethinyl Estradiol

Start date: December 2005
Phase: Phase 3
Study type: Interventional

The purpose of this 1-year study is to evaluate the efficacy and safety of a new contraceptive vaginal ring (CVR) delivering low doses of Nestorone (NES), a new, nonandrogenic progestin, and ethinyl estradiol (EE), an estrogen used in oral contraceptives. The CVR, which is made of silicone rubber, is designed to be used for 1 year (13 menstrual cycles) before replacement is required.

NCT ID: NCT00262600 Completed - Stroke Clinical Trials

Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate

Start date: December 2005
Phase: Phase 3
Study type: Interventional

The primary objective of this trial is to demonstrate the efficacy and safety of dabigatran etexilate in patients with non-valvular atrial fibrillation for the prevention of stroke and systemic embolism.