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Acute Myeloid Leukemia clinical trials

View clinical trials related to Acute Myeloid Leukemia.

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NCT ID: NCT03769532 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia

MRD-guided Treatment in NPM1mut AML Patients

PEMAZA
Start date: December 2018
Phase: Phase 2
Study type: Interventional

Evaluation the safety and efficacy of Pembrolizumab (PEM) when administered in combination with standard Azacitidine (AZA) in nucleophosmin (NPM1) mutated AML patients with molecular relapse defined by the presence of measurable residual disease (MRD).

NCT ID: NCT03760666 Recruiting - Clinical trials for Acute Myeloid Leukemia

A Study of Brequinar in Subjects With Relapsed/Refractory Acute Myeloid Leukemia

Start date: November 26, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

A Phase 1b/2a multi-center, open-label, non-randomized study to assess the safety, tolerability and efficacy of dose-adjusted brequinar in adult subjects with acute myeloid leukemia (AML).

NCT ID: NCT03760523 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia

Dose Escalation Study of Minnelide in Relapsed or Refractory Acute Myeloid Leukemia

Start date: February 2019
Phase: Phase 1
Study type: Interventional

This study is to determine the safety and recommended dosing of Minnelide in Acute Myeloid Leukemia (AML)

NCT ID: NCT03755856 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia

Long-term Outcomes for Acute Myeloid Leukemia Patients

1621-QLG-LG
Start date: January 2019
Phase:
Study type: Observational

This international observational study aims at examining the patterns of health-related quality of life differences between long-term acute myeloid leukemia patients and their healthy peers from the general population.

NCT ID: NCT03747757 Recruiting - Clinical trials for Acute Myeloid Leukemia

Cognitive Behavioral Therapy in Helping Patients With Acute Myeloid Leukemia With Cancer-Related Fatigue

Start date: November 29, 2018
Phase: N/A
Study type: Interventional

This trial studies how well cognitive behavioral therapy works in helping patients with acute myeloid leukemia with cancer-related fatigue. Behavioral therapy uses methods to help patients change the way they think and act. Behavioral skills may help patients with acute myeloid leukemia cope with anxiety, depression, and other factors that may influence their level of cancer-related fatigue.

NCT ID: NCT03737955 Recruiting - Clinical trials for Acute Myeloid Leukemia

Fractionated Gemtuzumab Ozogamicin in Treating Measurable Residual Disease in Participants With Acute Myeloid Leukemia

Start date: November 30, 2018
Phase: Phase 2
Study type: Interventional

This phase II trial studies how well fractionated gemtuzumab ozogamicin works in treating measurable residual disease in participants with acute myeloid leukemia. Antibody-drug conjugates, such as gemtuzumab ozogamicin, may block cancer growth in different ways by targeting certain cells.

NCT ID: NCT03735446 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia

Prexasertib in Combination With MEC in Relapsed/Refractory AML and High Risk MDS - a Phase I Trial

Start date: November 30, 2018
Phase: Phase 1
Study type: Interventional

This research study is studying a targeted therapy combined with chemotherapy as a possible treatment for acute myeloid leukemia (AML) or high risk myelodysplastic syndrome (MDS). The drugs involved in this study are: - Prexasertib (LY2606368) - Mitoxantrone - Etoposide - Cytarabine

NCT ID: NCT03734601 Recruiting - Clinical trials for Acute Myeloid Leukemia

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Start date: November 5, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate whether addition of a low dose of total body irradiation (TBI) to a standard preparation for transplant [total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG)] conditioning will help to augment donor chimerism without reducing tolerability of this regimen or increasing the risk of graft-vs-host disease (GVHD)

NCT ID: NCT03728699 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia

Microbiota Changes in Acute Myeloid Leukemia Patients Undergoing Intensive Chemotherapy

Start date: December 2018
Phase:
Study type: Observational

This is a prospective, observational study to collect stool and blood from acute myeloid leukemia patients undergoing intensive chemotherapy.

NCT ID: NCT03728335 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia

Enasidenib as Maintenance Therapy in Treating Patients With Acute Myeloid Leukemia With IDH2 Mutation After Donor Stem Cell Transplant

Start date: December 15, 2018
Phase: Phase 1
Study type: Interventional

This phase I trial studies the side effects of enasidenib as maintenance therapy in treating patients with acute myeloid leukemia with IDH2 mutation following donor stem cell transplant. Enasidenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.