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NCT ID: NCT05665075 Recruiting - AML, Adult Clinical Trials

Natural Killer (NK) Cell Therapy Targeting CD33 in Acute Myeloid Leukemia

Start date: December 24, 2022
Phase: Phase 1
Study type: Interventional

This is an open-label, Phase I study of QN-023a (allogeneic CAR-NK cells targeting CD33) in relapsed/refractory Acute Myeloid Leukemia (AML). The clinical study is to evaluate the safety, tolerability and preliminary efficacy of QN-023a in patients with relapsed/refractory AML,where a "3+3" enrollment schema will be utilized at dose escalation stage. Up to 19 patients will be enrolled.

NCT ID: NCT05665010 Recruiting - Clinical trials for Diminished Ovarian Reserve

Precise Stratification of Genetic Risk of Ovarian Function Impairment

Start date: November 1, 2021
Phase:
Study type: Observational

Aging is a common problem in human society at present. The fertility decline, perimenopausal symptoms and senile diseases caused by ovarian aging seriously affect women's own health, offspring's health, family and social stability, and endanger national population security. Accurate stratification of genetic risk of ovarian aging has practical significance. Early and accurate identification of high-risk groups of premature ovarian aging can help such women to start early protection of ovarian function, preserve fertility to a greater extent, improve fertility quality, and also be conducive to early prevention and treatment of other systemic diseases and prognosis.

NCT ID: NCT05664971 Recruiting - Clinical trials for Advanced Lung Cancer

JS004 Combined With Toripalimab and With Standard Chemotherapy Treat Patients With Advanced Lung Cancer

Start date: February 9, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open-label phase Ib/II clinical study to evaluate the safety, tolerability, pharmacokinetics and initial efficacy of JS004 injection combined with toripalimab and with or without standard chemotherapy in patients with advanced lung cancer

NCT ID: NCT05664737 Recruiting - Anemia Clinical Trials

A Study to Determine the Efficacy and Safety of Luspatercept in Adult and Adolescent Participants With Alpha (α)-Thalassemia

Start date: December 9, 2022
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the efficacy and safety of luspatercept plus best supportive care (BSC) vs placebo plus BSC on anemia in adult participants with α-thalassemia hemoglobin H (HbH) disease and determine the safety and drug levels in adolescent participants.

NCT ID: NCT05664386 Recruiting - Anesthesia Clinical Trials

Effect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery

Start date: April 10, 2023
Phase: Phase 4
Study type: Interventional

To study the Effect of Ciprofol Infusion for Induction and Maintenance of anesthesia on Hemodynamics and Postoperative Recovery in Patients Undergoing Thoracoscopic Lobectomy:a randomized, controlled trial.

NCT ID: NCT05664087 Recruiting - Periodontitis Clinical Trials

Effect of Photodynamic Therapy on Soft Tissue Healing After Tooth Extraction at Sites of Periodontal Infection

Start date: February 14, 2023
Phase: N/A
Study type: Interventional

Main Purpose: To evaluate the effect of photodynamic therapy on soft tissue healing after tooth extraction at periodontal infection site, and to compare the effect on pain degree and bone tissue remodeling after tooth extraction.

NCT ID: NCT05663307 Recruiting - Clinical trials for Ischemic Stroke, Acute

The Effect of Ginkgolide on Clinical Improvement of Patients With Acute Ischemic Stroke

Start date: January 1, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to evaluate the safety and effectivity of Ginkgo diterpene lactone meglumine injection tn the treatment of acute ischemic stroke

NCT ID: NCT05663281 Recruiting - Thrombosis Clinical Trials

Thrombus Imaging and Treatment Analytics in Neurology

Titan
Start date: December 15, 2022
Phase:
Study type: Observational

In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.

NCT ID: NCT05662956 Recruiting - Clinical trials for Acute Myeloid Leukemia

A Clinical Study of VA-CAG as Induction Therapy in Newly Diagnosed AML Patients

Start date: December 1, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to assess the therapeutic efficacy and safety of venetoclax in combination with azacitidine and CAG(VA-CAG) as induction regimen in newly diagnosed young patients with acute myeloid leukemia(AML).

NCT ID: NCT05662813 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Almonertinib Therapy in Patients With Abnormal Liver Function After EGFR-TKI Treatment, or Almonertinib First-line Therapy in Patients With Basic Hepatopathy

Start date: November 9, 2022
Phase: Phase 2
Study type: Interventional

To assess the efficacy and safety of Almonertinib therapy in patients with abnormal liver function after first/second generation EGFR-TKI treatment, or Almonertinib first-line therapy in patients with basic hepatopathy and locally advanced or metastatic EGFR-mutant non-small cell lung cancer.