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NCT ID: NCT03681041 Recruiting - Trauma Clinical Trials

Pancreatic Injury and Management Outcome

Start date: January 1, 2000
Phase:
Study type: Observational

Pancreatic injury is a relatively rare and result in significant morbidity and mortality. Estimates for the incidence of pancreatic injury range from 0.2-12% of abdominal traumas. Many factors, such as patient stability, the acuity of concomitant life-threatening injuries, and the need for damage control procedures must therefore be balanced when considering the proper approach to pancreatic injury management. However, few prospective studies have investigated the perioperative management of patients with pancreatic trauma.

NCT ID: NCT03680261 Not yet recruiting - Gastric Cancer Clinical Trials

Enriched-CRT 2017: Advanced Gastric Cancer With LN+ and LVI+, Chemotherapy vs. Chemoradiotherapy

Start date: October 1, 2018
Phase: Phase 3
Study type: Interventional

This Enriched-CRT 2017 trial is a prospective, multicenter trial for adjuvant chemoradiotherapy (CRT) and chemotherapy (CT) in radical resected advanced gastric cancer (GC) patients with lymph node metastasis (LN+) and lymphovascular Invasion (LVI+). The primary purpose of this study is to evaluate the 3-year overall survival (OS) of enrolled patients receiving adjuvant chemoradiotherapy compared with those receiving adjuvant chemotherapy. The second purpose is to evaluate 3-year disease free survival (DFS) and determine the safety of CRT compared with CT in the patients enrolled in this study.

NCT ID: NCT03680222 Not yet recruiting - Thyroid Cancer Clinical Trials

Effect of Reversed Tracking Method for Identification of EBSLN in Thyroid Surgery

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

The feasibility and effectiveness of Reversed Tracking Method for the identification and protection of extralaryngeal nerve branches in thyroid surgery were analyzed. Evidence-based medical evidence was used to evaluate the importance of EBSLN recognition and protection in thyroid surgery.

NCT ID: NCT03680183 Recruiting - Hepatitis B Clinical Trials

Clinical Pharmacokinetics of TKIs in Chinese Patients of Hepatitis B (HBV)

Start date: May 22, 2018
Phase:
Study type: Observational [Patient Registry]

The study will explore the characteristics in clinical pharmacokinetics of gefitinib, erlotinib,afatinib,osimertinib, crizotinib, apatinib, icotinib in Chinese patients of Non-small-cell lung cancer and hepatitis B. The study is self-controlled. The plasma concentration of tyrosine kinase inhibitors will be analyzed before and after system treatment of HBV.

NCT ID: NCT03680053 Not yet recruiting - Infertility Clinical Trials

Comparison of the Live Birth Rate Between the PPOS and the GnRH Antagonist Protocol in Patients Undergoing IVF

Start date: September 2018
Phase: N/A
Study type: Interventional

A randomized comparison of the live birth rate between the progestin-primed ovarian stimulation protocol and the gonadotrophin releasing hormone antagonist protocol in patients undergoing in vitro fertilization Research question Does the live birth rate of the progestin-primed ovarian stimulation protocol comparable with the GnRH antagonist protocol for patients undergoing IVF? Design This is a multi-centre randomized trial. Research plan Population: Infertile women who have medical indication for IVF will be recruited for study if they fulfil the selection criteria. Intervention: Women will receive oral dydrogesterone 20mg daily from Day 3 till the day of ovulation trigger. Comparator: Women will receive antagonist (Cetrorelix 0.25mg) once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger. Outcomes: The primary outcome is the live birth rate the first FET. Ovarian stimulation, egg retrieval, embryos frozen and frozen embryo transfer will be performed according to the standard operating procedures of the centres.

NCT ID: NCT03679936 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Diagnostic Significance of Single Center, Open and Prospective Evaluation of <Sup>18<Sup>F-FDG PET/CT Dynamic Imaging and Genomic Sequencing in Detecting Metastatic Lesion of Non-small Cell Lung Cancer

Start date: January 3, 2018
Phase:
Study type: Observational

The purpose of this study is to evaluate the diagnostic value of 18F-FDG PET/CT dynamic imaging in metastasis of non-small cell lung cancer (NSCLC). The investigators will collect dynamic 18F-FDG PET/CT scan and correlate the imaging findings with genomics and histopathological features of biopsy of primary or / and metastatic lesions in patients with newly diagnosed non-small cell lung cancer (NSCLC).

NCT ID: NCT03679143 Not yet recruiting - Influenza Clinical Trials

The Safety, Tolerability and Pharmacokinetic Study of ZSP1273 in Healthy Volunteers.

Start date: September 20, 2018
Phase: Phase 1
Study type: Interventional

This is a single center,double-blind,randomized,parallel design, single and multiple dose trial to evaluate the pharmacokinetics(PK), safety and tolerability of ZSP1273,and the effect of food on ZSP1273 Pharmacokinetics.

NCT ID: NCT03679091 Recruiting - Platelet Reactivity Clinical Trials

Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.

Start date: August 29, 2018
Phase: Phase 4
Study type: Interventional

Ticagrelor has been demonstrated to provide a more rapid and more powerful inhibition of platelet aggregation compared with clopidogrel in coronary artery disease (CAD) patients. However, current guidelines recommend ticagrelor 90 mg twice daily might not be suitable for patients of Chinese. Therefore, the investigators performed this study to observe the efficacy of 60-mg ticagrelor in comparison to 75-mg clopidogrel in Chinese patients with stable CAD.

NCT ID: NCT03679039 Recruiting - Clinical trials for Colorectal Cancer With Liver Metastases

A Model for Predicting the Efficacy of Conversion Therapy for Patients With Colorectal Cancer Liver Metastases by the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA

Start date: September 20, 2018
Phase:
Study type: Observational

In this study, the investigators establish a model for predicting the efficacy of conversion therapy for the patients with unresectable liver metastases of colorectal cancer based on the detection of 5-hydroxymethylcytosine (5-hmC) in training group and validate the effectiveness of the model using a validation group.

NCT ID: NCT03678649 Recruiting - Clinical trials for Head and Neck Neoplasms

A Prospective Randomized Trial of Capecitabine Treatment in Patients With HNSCC

Start date: September 10, 2018
Phase: Phase 2
Study type: Interventional

This prospective randomized controlled clinical Trial will be performed in patients with locally advanced squamous cell carcinoma of the head and neck. The objectives of the trial are to compare the efficacy and safety of Capecitabine treatment with placebo as adjuvant therapy to patients who have received radiotherapy.