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NCT ID: NCT03586557 Not yet recruiting - Optic Neuritis Clinical Trials

Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

Patients aged between 18 and 70 with acute aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) positive optic neuritis, irrespective of prior using of corticosteroids in this episode of disease, are chosen by the physician. Patients will then be randomized to receive high dose of intravenous corticosteroids combined with plasma exchange (PE), or merely high dose of intravenous corticosteroids followed subsequent taper. The main outcome of visual acuity and OCT parameters will be compared at baseline, one, three and six months after treatments, and other assessments will also be recorded and compared. This will allow for determination on whether additional PE plays a role in better prognosis in acute AQP4-IgG positive optic neuritis.

NCT ID: NCT03586271 Recruiting - Intraocular Lens Clinical Trials

Comparison of the Visual Performance After Implantation of Multifocal Lens

Start date: August 2, 2018
Phase:
Study type: Observational

This is a prospective, consecutive, nonrandomized,comparative study. Comparison of the Visual Performance After Implantation of a Trifocal Intraocular Lens and Two Bifocal Intraocular Lenses

NCT ID: NCT03586193 Recruiting - Retinal Disease Clinical Trials

Pars Plana Vitrectomy Alone in the Treatment of Macular Schisis in High Myopic Eyes

Start date: May 1, 2018
Phase:
Study type: Observational

High myopic schisis (HMF) has the clinical feature of separation between retinal layers. It is sometimes accompanied with foveal retinal detachment, macular lamellar hole, epiretinal membrane and vitreous retraction. HMF may develop to macular hole, macular detachment and will damage the visual function. Pars plana vitrectomy (PPV) is a commonly used surgery in the treatment of HMF. PPV together with internal limiting membrane (ILM) peeling and long-term gas tamponade was reported to be safe and effective. But nowadays there was no available long-term gas in our country. Also, whether ILM peeling is necessary remains controversial, Indole cyanine green (ICG)was proved to have potential toxicity to the retina and the ILM peeling has the risk of causing secondary macular hole. We propose to make a prospective nonrandomized controlled study to evaluate the safety and efficiency of using PPV alone in the treatment of HMF.

NCT ID: NCT03585517 Recruiting - AML Clinical Trials

Safety and Efficacy Evaluation of IM23 CAR-T Cells (IM23CAR-T)

Start date: July 21, 2018
Phase: Phase 1
Study type: Interventional

Assessment of the Safety and Feasibility of Administering T Cells Expressing an Anti-CD123 Chimeric Antigen Receptor to Patients With CD123+ AML

NCT ID: NCT03585322 Recruiting - Chronic Hepatitis B Clinical Trials

APG-1387 Study of Safety, Tolerability ,PK/PD in Patients With Chronic Hepatitis B

Start date: July 20, 2018
Phase: Phase 1
Study type: Interventional

This study is Multiple Ascending Dose study to Explore the Tolerability, Safety and Pharmacokinetics/Pharmacodynamics of APG-1387 in Chronic Hepatitis B Patients.

NCT ID: NCT03585166 Recruiting - Liver Cancer Clinical Trials

Nursing Fro Laparoscopic vs. Open Hepatectomy

Start date: October 1, 2017
Phase:
Study type: Observational

This study was divided into laparoscopic hepatectomy (observation group) and laparoscopic hepatectomy (control group).Compared two groups of age, sex, body mass index (BMI), tumor diameter, number of tumors (single/multiple), pathologic characteristics, HBsAg (positive/negative), liver function, AFP, Child - Pugh, grading, nursing method and comparison of two groups of patients after surgery (surgical incision length, intraoperative blood, intraoperative blood transfusion and transfusion volume, operation time) the number of cases of and postoperative rehabilitation (death cases, for the first time the meal time, anus exhaust time, analgesic bed, first time, the abdominal cavity drainage tube time, length of hospital stay, postoperative days and liver function index.Follow-up: the survival rates of the two groups were compared in six months, one year, two years, three years and five years.In this study, the initial selection of the minimum sample size of 30 cases, plus 20% inefficiencies, the final initial selection of 36 cases, and the later expansion of the sample size of 100 cases.The research date starts on October 1, 2017.

NCT ID: NCT03585062 Recruiting - Pancreatic Cancer Clinical Trials

Trial of Neoadjuvant Chemotherapy With S1 Plus Paclitaxel-albumin on Pancreatic Cancer

Start date: November 20, 2017
Phase: Phase 2
Study type: Interventional

The study is to evaluate the R0 resection rate of patients with unresectable locally advanced pancreatic cancer ,after treated with S-1 plus Paclitaxel-albumin as neoadjuvant chemotherapy protocols

NCT ID: NCT03584529 Not yet recruiting - Clinical trials for Vitamin D Deficiency

Association Between Vitamin D and the Development of Uterine Fibroids

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

the aim of this randomised clinical trial study is to evaluate whether supplementation with vitamin D could inhibit the growth of uterine fibroids in reproductive stage women.

NCT ID: NCT03584139 Recruiting - Cataract Clinical Trials

IRIS Hook Assisted Phacoemulsification in Vitrectomized Eyes

Start date: April 1, 2018
Phase: N/A
Study type: Interventional

Although phacoemulsification in previously vitrectomized eyes is a relatively safe procedure comparing with extracapsular cataract surgery, it is still more challenging than in eyes without previous vitrectomy because of the anatomical differences after PPV. Intraoperative difficulties such as abnormal anterior chamber deepening, unstable posterior capsules, and weakened zonules have been reported. The investigators aim to evaluate the efficacy and safety of a new simple iris hook assisted maneuver in phacoemulsification, then compare the incidence of intraoperative and postoperative complications of this technique with traditional phacoemulsification and phacoemulsification with 25-gauge vitreous irrigation. The latter two surgery methods are currently popular for cataract in vitrectomized eyes.

NCT ID: NCT03583619 Recruiting - Breast Neoplasms Clinical Trials

Randomized Trial of Accelerated Partial Breast Irradiation

Start date: July 19, 2017
Phase: Phase 2
Study type: Interventional

This study is to compare radiation toxicity of accelerated partial breast irradiation (ABPI) with whole breast irradiation (WBI) in low-risk breast cancer.