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NCT ID: NCT03810391 Completed - Clinical trials for Total Dose of Butorphanol

Using Preoperative Anxiety Score to Determine the Total Dose of Butorphanol for Sedation

Start date: December 1, 2017
Phase: Phase 2
Study type: Interventional

Orthopedic surgeries are considered to be discomfortable and the sense of fear and anxiety of patients who already have preoperative anxiety may be aggravated by intraoperative stimulation, which may contribute to postoperative complications. Previous studies have found that high anxiety predicts increased sedative requirements. Therefore, the investigators explored the relationship between anxiety and intraoperative butorphanol requirements and the investigators evaluated the specific sedative requirement which can keep satisfactory sedative state for patients by preoperative anxiety score

NCT ID: NCT03810339 Recruiting - Advanced Cancer Clinical Trials

Toripalimab as Monotherapy in Participants With POLE or POLD-1 Mutated and Non-MSI-H Advanced Solid Tumors

Start date: January 15, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the response of toripalimab , a PD1 antibody, in participants with POLE or POLD-mutated and non microsatellite instability (non-MSI-H) advanced solid cancers.

NCT ID: NCT03810274 Completed - Clinical trials for Nasopharyngeal Carcinoma

3DV+TPS Software Outlines the Radiotherapy of Nasopharyngeal Carcinoma

Start date: February 1, 2012
Phase:
Study type: Observational

Comparing the accuracy and speed of 3DV+TPS software with imported TPS and domestic TPS to outline the contours of crisis organs, it is proved that 3DV+TPS has superiority compared with domestic TPS, and it has non-inferiority compared with imported TPS, indicating that the software can improve contour sketching accuracy. And speed, reduce the burden on doctors, improve medical efficiency.

NCT ID: NCT03810157 Recruiting - Pregnancy Outcomes Clinical Trials

Does LAH May Improve the Pregnancy Outcomes?

Start date: December 26, 2018
Phase: N/A
Study type: Interventional

A defect in the hatching stage is considered an important cause of implantation failure. Therefore, assisted hatching (AH), which involves artificial disruption of the zona pellucida, has been proposed as a method for improving the capacity of the embryo to implant. But the advantage of using laser to facilitate the hatching process of embryos in ART practice is debatable, and an optimum strategy for performing LAH remains elusive. Therefore, the aim of this study was to evaluate the effects of laser-assisted hatching(LAH) on clinical outcomes. Patients were randomly divided into control and LAH groups. The zona pellucida was thinned or drilled with a diode laser. Relevant parameters are recorded to evaluate the validity of LAH in ART.

NCT ID: NCT03810040 Not yet recruiting - Embryo Clinical Trials

Effect of Degranulation Needle With Different Diameters on the Rate Good Embryo in IVF

Start date: February 2019
Phase: N/A
Study type: Interventional

Good-quality embryos are critical for the success of in vitro fertilization (IVF). But, to date, there is no report of the effect of different diameters denuding pipette on the embryos quality. To investigate the effect of denuding pipette in IVF outcomes, we plan to recruit women undergoing IVF treatment cycles and classified them into two groups according to the different diameters. Consequently, the rate of fertilization, zygotes cleaved, top quality embryos on D3, and blastocysts obtained were recorded.

NCT ID: NCT03810001 Recruiting - Fertilization Clinical Trials

Mechanical Stimulation Improve the Fertilization in ICSI Cycle

Start date: November 11, 2018
Phase: N/A
Study type: Interventional

Most fertilization failures after ICSI are caused by failure of oocyte activation defects. But, to date, there is no effective method to overcome this obstacle. To investigate the effect of mechanical stimulation on fertilization failures, investigators plan to recruit women undergoing ICSI treatment cycles. The retrieved sibling oocytes from the patients were randomly divided into two groups. The control group conducted the standard ICSI procedure, while the experimental group conducted the modified ICSI procedure.Consequently, the fertilization rate, 2PN (two pronuclei) rate, 1PN rate, oocyte degradation rate,and exploitable embryos on D3 were recorded to evaluate ICSI cycle outcomes.

NCT ID: NCT03809936 Completed - Clinical trials for Disorder of Consciousness

Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

To date, several studies have focused on the use of transcranial direct current stimulation(tDCS) in patients with impaired consciousness.However,its therapeutic effects have been variously documented.So,in this study ,investigators explore the effects of tDCS.

NCT ID: NCT03809923 Recruiting - Dexmedetomidine Clinical Trials

Dexmedetomidine Combined With Lidocaine Infusion Affect PONV

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV). The investigators investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the incidence of PONV after laparoscopic hysterectomy. METHODS: One hundred and twenty women with elective laparoscopic hysterectomy were randomly divided into two groups: patients in the lidocaine combined with dexmedetomidine group (LD group, n=60) received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and dexmedetomidine (0.5 μg/kg loading, 0.4 μg/kg/h infusion) respectively. Patients in the control group (CON group, n=60) received the equal volume of saline. Primary outcome was the incidence of the first 48 h nausea, vomiting and PONV after surgery. The secondary outcomes included perioperative propofol and remifentanil consumption, postoperative fentanyl requirement, Ramsay sedation score, and bradycardia during post-anaesthesia care unit (PACU) stay.

NCT ID: NCT03809767 Recruiting - Lymphoma Clinical Trials

A Phase I Study of CS1003 in Subjects With Advanced Solid Tumors or Lymphomas

Start date: October 29, 2018
Phase: Phase 1
Study type: Interventional

This is a phase Ia/Ib, open-label, multiple-dose, dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity of CS1003 in subjects with advanced solid tumors or lymphoma.

NCT ID: NCT03809754 Not yet recruiting - Clinical trials for Percutaneous Coronary Intervention

Optical Coherence Tomography Guided Percutaneous Coronary Intervention for Drug-eluting In-stent Restenosis

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

This study is a prospective, registry trial aimed to compare the clinical and angiographic outcomes of OCT-guided and angiography-guided PCI in patients with coronary DES-ISR.