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NCT ID: NCT03254654 Recruiting - Clinical trials for Advanced Triple-Negative Breast Cancer

Vinorelbine Plus Apatinib Versus Vinorelbine in Advanced Triple-Negative Breast Cancer

Start date: August 2017
Phase: Phase 2
Study type: Interventional

Vinorelbine Plus Apatinib Versus Vinorelbine in Advanced Triple-Negative Breast Cancer

NCT ID: NCT03254017 Recruiting - Clinical trials for Treatment Resistant Major Depressive Disorder

Remotely Programmed Deep Brain Stimulation of the Bilateral Habeluna for Treatment- Resistant Major Depression: An Open Label Pilot Trial

Start date: July 24, 2017
Phase: N/A
Study type: Interventional

The habenula(Hb) is an epithalamic structure located at the center of the dorsal diencephalic conduction system, a pathway involved in linking forebrain to midbrain regions. An increasing number of studies indicates that that overactivity in the lateral habeluna(LHb) is present during depressed states, where it could drive the changes in midbrain activity linked to depression. Deep brain stimulation(DBS) of the major afferent bundle (i.e., stria medullaris thalami) of the LHb can treat treatment-resistant major depression(TRD). There is no clinical case of directly stimulating habeluna for treatment TRD. This research will investigate effectiveness bilateral DBS to habenula for patients with TRD. Programming is a crucial aspect of DBS which directly influences its therapeutic efficacy. Researchers need to ascertain optimum stimulation parameters to help patients achieve optimal control of clinical symptoms. Remote programming of DBS can markedly improve patient convenience, minimize risk of infection and total treatment time and lead to an overall benefit for doctors and patients alike. This research will also investigate safety and benefit of remote programming of DBS.

NCT ID: NCT03253146 Recruiting - Sepsis Clinical Trials

The Role and Mechanism of Vimentin in Sepsis Patients

Start date: July 1, 2016
Phase: N/A
Study type: Observational

Sepsis is the most common cause of death in the clinical critically ill patients. We have successfully screened the sepsis biomarkers by clinical proteomics approach and found that Vimentin (VIM) played an important role in the occurrence and development of sepsis. However, the exact mechanism is remaining unclear. In this study, the relationship between the changes of peripheral circulation VIM expression and different stages of sepsis development will be further verified in lager clinical trials, as well as the relationship between VIM expression and apoptosis of immune cells (e.g lymphocytes) will also be clarified. This may indicate that the role of VIM in the cell-mediated immunity apoptosis and inflammation-related pathways. Through the implementation of this study, we can clarify the clinical value of VIM and the mechanism of VIM-mediated immune cell apoptosis during the sepsis development from the molecular level, and determine whether the VIM as a new target for sepsis diagnosis and treatment.

NCT ID: NCT03252925 Recruiting - Clinical trials for Thrombotic Microangiopathies

A Safety and Efficacy Study of NAC in Patients With TA-TMA

Start date: June 1, 2017
Phase: Phase 3
Study type: Interventional

HSCT associated thrombotic microangiopathy(TA-TMA) is a heterogeneous, fatal disorder seen within 100 days post-transplant and presents with thrombocytopenia, hemolysis, acute renal failure, mental status changes and involvement of other organs. N-Acetylcysteine (NAC) is a small, simple molecule that began as a generic drug almost 40 years ago. It has since been approved by the FDA for many indications. The investigators conducted an prospective clinical trial to evaluate the safety and efficiency of NAC in patients with TA-TMA.

NCT ID: NCT03252665 Not yet recruiting - Clinical trials for ST Segment Elevation Myocardial Infarction

Efficacy of Intracoronary Infusion of Different Medicine in STEMI Patients Undergoing Primary PCI

Start date: September 1, 2017
Phase: Phase 4
Study type: Interventional

The study intends to evaluate the efficacy of different medicine delivering by targed perfusion catheter incoronary administration on epicardial, myocardial perfusion and clinical outcomes in STEMI patients undergoing primary PCI.

NCT ID: NCT03252639 Recruiting - Clinical trials for Renal Artery Stenosis

A Study of Using Parenchymal Blood Volume(PBV) for Endovascular Treatment of Renal Arterial Stenosis

Start date: November 2016
Phase: N/A
Study type: Observational

This study will use PBV technique to quantitatively assess the improvement of renal perfusion before and after endovascular treatment (EVT) of renal artery stenosis.

NCT ID: NCT03252457 Not yet recruiting - Clinical trials for Immune Thrombocytopenia

Decitabine Combining Dexamethasone Versus Dexamethasone in Management of ITP

Start date: September 1, 2017
Phase: Phase 3
Study type: Interventional

The project was undertaking by Qilu Hospital of Shandong University and other 4 well-known hospitals in China. In order to report the efficacy and safety of decitabine combining with dexamethasone for the treatment of adults with immune thrombocytopenia (ITP), compared to dexamethasone alone .

NCT ID: NCT03252171 Completed - Clinical trials for CAR-T Cell Immunotherapy

CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients

Start date: October 2015
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of CAR-T cell immunotherapy in treating with GD2 positive glioma patients.

NCT ID: NCT03252067 Recruiting - Pharmacokinetics Clinical Trials

Tear Concentrations and Pharmacokinetics of Azithromycin Eye Drops in Healthy Volunteers

Start date: August 2, 2017
Phase: Phase 1
Study type: Interventional

To evaluate azithromycin tear concentrations after one drop of azithromycin eyedrops (2.5ml/25mg) in healthy volunteers.

NCT ID: NCT03251898 Recruiting - Neonatal Infection Clinical Trials

Correlation Between Premature Rupture of Membranes and Early-onset Neonatal Infections

Start date: August 15, 2017
Phase: N/A
Study type: Observational [Patient Registry]

This study hypothesizes that early-onset neonatal Infections are related to premature rupture of membrane (PROM) and that early intervention can improve the prognosis of newborns. The objective of this study is to analyze the correlation between PROM and early-onset neonatal infections and to assess the prognosis of newborns. A cohort study is designed to implement the study. The subjects of study group are pregnant women who are diagnosed as PROM or chorioamnionitis and whose gestational age is ≥ 24 weeks. The subjects of control group are pregnant women without PROM and chorioamnionitis. Control group and research group are paired at 1: 1 ratio. The main contents of the study include three aspects. (1) The correlation between PROM and chorioamnionitis. (2) The correlation between PROM and early-onset neonatal infections. (3) The pathogenesis of intrauterine infection and neonatal infection.