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NCT ID: NCT00662649 Completed - Multiple Sclerosis Clinical Trials

Long-term Efficacy and Safety of Fingolimod (FTY720) in Patients With Relapsing-remitting Multiple Sclerosis

Start date: February 2008
Phase: Phase 3
Study type: Interventional

This extension study of was designed to evaluate the long-term safety, tolerability, and efficacy of fingolimod (FTY720) in patients with multiple sclerosis. The Extension study was an extension to the 24-month Core study (CFTY720D2301/NCT00289978).

NCT ID: NCT00661206 Active, not recruiting - Clinical trials for Coronary Artery Disease

Safety and Efficacy of Six Months Dual Antiplatelet Therapy After Drug-Eluting Stenting

ISAR-SAFE
Start date: September 2008
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether a 6 month duration of clopidogrel therapy after DES implantation is not inferior to that of a 12 month therapy.

NCT ID: NCT00658515 Completed - Clinical trials for Coronary Heart Disease

A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome

Start date: April 2008
Phase: Phase 3
Study type: Interventional

This study will evaluate the potential of RO4607381 to reduce cardiovascular morbidity and mortality in stable coronary heart disease patients with recent Acute Coronary Syndrome (ACS) and evaluate the long term safety profile of the drug. Eligible patients in stable condition will be randomized to receive either RO4607381 600mg po or placebo po, daily, together with a background of standard medication for ACS (including aspirin, antihypertensives and statins). The anticipated time on study treatment is 2+ years, and the target sample size is 15,600 individuals.

NCT ID: NCT00658294 Completed - Clinical trials for Alveolar Echinococcosis

Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles

Start date: January 2008
Phase: N/A
Study type: Observational

The aim of this study is to evaluate PET-CT and EmII/3-10 serology as potential markers to assess the parasitocidal effect of benzimidazoles - Trial with medicinal product

NCT ID: NCT00657969 Active, not recruiting - Stroke Clinical Trials

Looking For Genetic and Environmental Risk Factors and Therapeutic Aspects in Cervical Artery Dissections

CADISP
Start date: July 2005
Phase: N/A
Study type: Observational

The main purpose of this study is to look for genetic and environmental risk factors of cervical artery dissections, a major cause of ischemic stroke in young adults, in a large multicenter case-control trial

NCT ID: NCT00657683 Completed - Clinical trials for Invasive Group B Streptococcus (GBS) Disease

A Phase I, Randomized, Single-blind, Controlled, Single Center Study to Evaluate the Safety and Immunogenicity of a Dose Range of a Monovalent Glycoconjugate Antigen Vaccine of Group B Streptococcus in Healthy Women 18-40 Years of Age

Start date: December 2007
Phase: Phase 1
Study type: Interventional

The goals of the proposed study are to evaluate the safety, tolerability and immunogenicity of a GBS vaccine. Previous studies suggest that immune responses against GBS can protect humans from infection.

NCT ID: NCT00657436 Completed - Clinical trials for Myocardial Infarction

Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement

MyRiAD
Start date: March 2008
Phase: N/A
Study type: Observational

The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department. Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.

NCT ID: NCT00656747 Completed - Chronic Bronchitis Clinical Trials

Moxifloxacin Versus Amoxicillin Clavulanic Acid in Treatment of Acute Exacerbation of Chronic Bronchitis

Start date: March 2008
Phase: Phase 4
Study type: Interventional

A study to assess the safety and efficacy of moxifloxacin compared to that of amoxicillin-clavulanic acid for the treatment of subjects with acute exacerbation of chronic bronchitis.

NCT ID: NCT00656422 Terminated - Obesity Clinical Trials

Weight Gain, Eating Patterns, and Development of Body Composition During Initiation of Basal Insulin Therapy in Patients With Type 2 Diabetes: A Comparison of Insulin Detemir and Insulin Glargine

Start date: November 2007
Phase: Phase 3
Study type: Interventional

The main objective of this clinical trial is to investigate hepatic fat as the primary endpoint along with body fat, and weight changes after initiation of a basal insulin therapy together with data acquisition that is today's standard in studies investigating obesity and eating patterns with insulin detemir and insulin glargine.

NCT ID: NCT00656396 Completed - Clinical trials for Blood Loss, Surgical

Point of Care Coagulation Testing in Patients Undergoing Major Surgery

POC-OP
Start date: May 2008
Phase: Phase 3
Study type: Interventional

Bleeding is a frequent complication during surgery. The peri-operative administration of blood products, including packed red blood cells, thrombocytes and fresh frozen plasma (FFP), is often deemed necessary. Therefore the transfusion of allogenic blood products mandates strategies to optimize the clinical decision to transfuse. The decision to administer FFP is usually made in the absence of any data. Point of care testing of prothrombin time ensures that a major parameter of coagulation is readily available. The test is fast, easy to perform, inexpensive and may enable physicians to rationally determine the need for FFP. Objective of the study is to determine the effectiveness of point of care coagulation testing of prothrombin time to reduce the administration of FFP.