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NCT ID: NCT03249220 Not yet recruiting - Brain Injuries Clinical Trials

Clinical Pilot Study to Evaluate a New Multi-parameter Neuromonitoring Device in Brain-injured Patients

Start date: October 2017
Phase: N/A
Study type: Interventional

Clinical pilot study to evaluate a new multi-parameter neuromonitoring device that allows the measurement of regional cerebral blood flow (rCBF), intracranial pressure (ICP), brain temperature monitoring and ventricular cerebrospinal fluid (CSF) drainage in brain-injured patients.

NCT ID: NCT03247699 Active, not recruiting - CYP450 Phenotyping Clinical Trials

Pharmacokinetics of the Basel Phenotyping Cocktail Combination Capsule

Start date: June 12, 2017
Phase: N/A
Study type: Interventional

Healthy Subjects will receive treatment orally with 120-200ml tap water in fasted state. Treatment in period A is the "Basel phenotyping cocktail" capsule. Treatment in period B consists of simultaneous intake of isolated formulations. In both study arms peripheral venous and capillary blood (DBS) samples will be drawn

NCT ID: NCT03245866 Recruiting - Clinical trials for Subarachnoid Hemorrhage

Swiss Study on Subarachnoid Hemorrhage

Swiss SOS
Start date: January 1, 2009
Phase: N/A
Study type: Observational [Patient Registry]

This registry was created to assess management parameters of patients treated for aneurysmal subarachnoid hemorrhage in Switzerland. All Swiss hospitals with a neurosurgery department, an intensive care unit and an interventional neuroradiology team that treat neurovascular emergencies participate in the registry. Clinical parameters are entered into a common database. This database will provide (1) a nationwide assessment of the current standard of care and (2) the outcomes for patients in Switzerland including neuropsychological assessments.

NCT ID: NCT03243773 Recruiting - Acute Heart Failure Clinical Trials

Evaluation of Lung Ultrasound in Acute Heart Failure

Start date: March 1, 2016
Phase: N/A
Study type: Observational

Acute heart failure is a life threatening condition requiring rapid diagnosis and treatment. However, the differentiation between heart failure and other conditions presenting with acute dyspnea is notoriously difficult in the emergency room. Point-of-care lung ultrasound is a simple, rapid and noninvasive technique directly visualizing fluid content in the lung as evidence for acute heart failure. A number of publications showed the diagnostic utility of lung ultrasound in the diagnosis of heart failure, but many open questions remain. The goal of this study is to evaluate the diagnostic accuracy of lung ultrasound to predict a cardiac origin of dyspnea in unselected patients in the emergency room as compared to standard evaluation. Further goals are to evaluate if lung ultrasound provides additional diagnostic information as compared to clinical examination, NT-proBNP and chest X-ray, to compare the diagnostic accuracy of lung ultrasound in different patient subgroups (heart failure with preserved vs reduced ejection fraction, de novo vs decompensated chronic heart failure, age ≥75 vs <75 years, women vs men and presence vs absence of concomitant pulmonary disease) and to compare demographics and clinical characteristics in different patient populations. 300 patients, aged ≥18 years presenting to the emergency room (ER) with acute dyspnoe as principal complaint will undergo initial clinical assessment of the likely etiology of dyspnea by the ER physician in charge. The second assessment by the same physician will include results of NT-proBNP according to predefined cutoffs. Final diagnosis ("Gold Standard") will be done by two experienced investigators after patient discharge taking into account the complete medical record except the results of lung ultrasound. Assessment of chest X-ray and lung ultrasound by investigators will be preforemd blinded regarding all other results.

NCT ID: NCT03243435 Completed - Clinical trials for Breast Cancer Female

Sienna+MR Long-term Uptake

Start date: July 2016
Phase: N/A
Study type: Observational

In a previous study in 2012/2013 patients were injected a superparamagnetic iron oxide for sentinel lymph node detection. In this follow up study we want to investigate how much of this tracer is still detectable.

NCT ID: NCT03242993 Recruiting - Clinical trials for Metastatic Ovarian Cancer


Start date: April 1, 2017
Phase: Phase 1
Study type: Interventional

This is a clinical trial category C as this is a first in man trial with an unapproved investigational product. Nevertheless the risk is considered low due to the low dose ≤ 10μg. No toxicity effects were observed preclinically at a dose >1000 -fold the intended dose. Open-labeled, non-blinded, non-placebo controlled, multicenter study. Primary objective: Assessment of biodistribution and FR-specific tumor detection of [18F]- AzaFol as a PET imaging agent in patients with FR-positive and FR-negative metastatic cancer of the ovaries or lungs. Secondary objective: Calculation of the effective dose to the patient according to the tissue distribution data of [18F]-AzaFol (Dosimetry)

NCT ID: NCT03242837 Enrolling by invitation - Clinical trials for Psychological Stress

Psychobiological Evaluation of the Army Resilience Training

Start date: August 14, 2017
Phase: N/A
Study type: Interventional

This study evaluates the influence of a resilience training on psychobiological factors which are related to stress and resilience in young healthy male cadets. Half of participants will join in the resilience training, while the other half take part in a control-training (diversity management training).

NCT ID: NCT03241173 Not yet recruiting - Clinical trials for Advanced or Metastatic Malignancies

A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies

Start date: October 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine the safety, tolerability, and efficacy of INCAGN01949 when given in combination with immune therapies in participants with advanced or metastatic malignancies.

NCT ID: NCT03241121 Not yet recruiting - Obesity Clinical Trials

Study of Eating Patterns With a Smartphone App and the Effects of Time Restricted Feeding in the Metabolic Syndrome

Start date: August 2017
Phase: N/A
Study type: Interventional

SwissChronoFood - Study of eating patterns with a smartphone app and the metabolic effects of time restricted feeding in metabolic syndrome The purpose of this study is to assess eating patterns among teenagers and adults with a new method, going beyond the pen-and-paper food diaries, and to investigate whether time restricted feeding leads to weight loss, improvement in lipid and glucose metabolism in individuals with metabolic syndrome

NCT ID: NCT03238625 Recruiting - Anesthesia Clinical Trials

Painless Local Anaesthesia With Bicarbonate Admixture

Start date: June 20, 2017
Phase: Phase 2
Study type: Interventional

This study examines whether the injection of local anesthesia mixed with sodium bicarbonate in the ratio of 3:1 creates a less burning sensation and is as effective regarding the anesthetic effect as in the ratio of 9:1.