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NCT ID: NCT03805477 Not yet recruiting - Clinical trials for Bronchiolitis Obliterans Syndrome (BOS)

Nintedanib in Patients With Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem Cell Transplantation

NINBOST2018
Start date: February 2019
Phase: Phase 2
Study type: Interventional

This study investigates the safety and tolerability of Nintedanib in patients with bronchiolitis obliterans syndrome (BOS) following allogeneic hematopoietic cell transplantation. All study patients with BOS will be treated with the study drug Nintedanib (300 mg/day) as an add-on therapy to their basic immunosuppressive treatment over a 12-months treatment period.

NCT ID: NCT03802760 Recruiting - Cerebral Embolism Clinical Trials

Cerebral Microembolism in Cardiology

ZEMEK
Start date: October 24, 2018
Phase:
Study type: Observational

During different interventional cardiology procedures we aim to identify cerebral microemboli load. Further we aim to differentiate the quality and the quantity of cerebral microemboli.We will measure cerebral microemboli in different interventional phases, e.g. during valve deployment, rapid pacing, post-implantation.

NCT ID: NCT03800992 Not yet recruiting - Clinical trials for Epilepsy in Children

Bad News- Diagnosis: Epilepsy in Childhood

Bad news
Start date: February 2019
Phase:
Study type: Observational

"Bad news" are defined as"any information which adversely and seriously affects an individuals` view of future. Families of chronic ill children are exposed to a high stress load. This project is to investigate the stress burden directly after diagnosis of epilepsy in childhood and coping capabilities in the course of time and how quality of communication at the time of diagnosis effects stress perception and coping behaviour in the following 12 months. Perceived/ experienced advisory skills of the physician will be assessed by parents and children (older than eleven) on the basis of SPIKES - a Six-Step Protocol for Delivering Bad News. The subjective perception regarding quality of dialogue in relationship to childrens and their parents quality of life and their coping strategies will be assessed.

NCT ID: NCT03800147 Not yet recruiting - Clinical trials for Escherichia Coli Infections

Effects of Nutritional Fat on the Growth of Intestinal E. Coli

Start date: January 24, 2019
Phase: N/A
Study type: Interventional

Recent experiments in the lab of Prof. WD Hardt revealed, that in mice, 24 h exposure to a high-fat diet results in a breakdown of colonization resistance against Salmonella typhimurium. Mechanistic experiments identified bile acids as the mediator for reduced colonization resistance. Exposure to a high fat diet leads to increased bile acid secretion which in turn modify the intestinal microbiota. It is now the aim to verify the results of this study in human healthy volunteers. The nutritional habits of all participants will carefully be evaluated. In the intervention phase, participants will be exposed to either high-fat or low-fat diet and a controlled dose of the non-pathogenic bacteria E. coli Nissle. E. coli Nissle is the active compound for "Mutaflor®" and other probiotics. It is planned to enumerate E. coli Nissle counts in the stool after Mutaflor ingestion and to quantify other changes of the human microbiota. The hypothesis is that a high-fat diet leads to increased bile acid secretion results in favorable growth conditions for E. coli Nissle, resulting in high bacterial counts in the stool.

NCT ID: NCT03798015 Recruiting - Clinical trials for Mitral Valve Reconstruction

Neurologic Outcome After Mitral Valve Surgery

Start date: February 2009
Phase:
Study type: Observational

Reconstructive mitral valve surgery is increasingly done by minimal- invasive anterolateral thoracotomy technique in contrast to surgical approach by sternotomy. The minimal invasive approach is favourable regarding surgical trauma, length of hospital stay and amount of blood loss. This study is to investigate the neurological outcome after minimal- invasive mitral valve surgery compared to open mitral valve surgery by sternotomy. Pre-, intra- and postsurgical data from mitral valve surgery derived from the Basel mitral valve registry (collected from 2009 until now) will be analyzed.

NCT ID: NCT03797235 Recruiting - Regional Anesthesia Clinical Trials

The Impact of Nerve Cross Section Area on Sensory Block Onset

Start date: January 9, 2019
Phase: N/A
Study type: Interventional

The study aims to describe a correlation between the nerve cross section and the sensory or motor block onset time. Therefore, different nerve cross sections with their Motor and sensory onset times are compared in order to find a correlation. In the case of discovering a correlation, this could be translated into clinical practice, where a more tailored and individualized approach to performing peripheral nerve blocks would be possible, thus lowering the risks of adverse events occurring.

NCT ID: NCT03797131 Recruiting - Clinical trials for Urea Cycle Disorders

Clinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle Disorders

Start date: January 2019
Phase: N/A
Study type: Interventional

This clinical food study aims to explore the effect of KB195, a novel mixture of oligosaccharides, on the metabolism of nitrogen by the microbiome in patients with urea cycle disorders (UCDs). This will be done using a stable isotope to assess nitrogen metabolism in the blood, urine, and stool. The study will also assess the safety and tolerability of KB195 in patients with UCDs.

NCT ID: NCT03796377 Recruiting - Clinical trials for Drug Interaction Study

Rivaroxaban Hypericum Trial

Start date: January 3, 2019
Phase: Phase 1
Study type: Interventional

Single-center, open-label, sequential treatment study to investigate the influence of the combined P-glycoprotein and CYP3A4 inducer hypericum perforatum on the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy volunteers.

NCT ID: NCT03796000 Recruiting - Metabolic Disease Clinical Trials

Characterization of Human Intestinal Macrophages in Metabolic Disease

iMAC
Start date: May 14, 2018
Phase:
Study type: Observational

This is a prospective, observational study aiming at improving the understanding of the pathophysiology of metabolic disease. As inflammation has been recognized as a key characteristic of metabolic disease but its starting point is still unknown, the investigators' aim is to characterize intestinal macrophages from human gut biopsies taken in diagnostic endoscopies of the gastrointestinal tract or in bariatric surgeries for clinical reasons.

NCT ID: NCT03794544 Not yet recruiting - NSCLC Clinical Trials

Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer

Start date: January 28, 2019
Phase: Phase 2
Study type: Interventional

Study D9108C00002 (NeoCOAST) is a platform study assessing the effectiveness and safety of neoadjuvant durvalumab alone or in combination with novel agents in subjects with resectable, early-stage (Stage I [>2cm] to IIIA N0-1) non-small cell lung cancer (NSCLC).