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Asthma clinical trials

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NCT ID: NCT03635710 Recruiting - Asthma Clinical Trials

Smartphone Enabled Detection of Nocturnal Cough Rate and Sleep Quality as a Prognostic Marker for Asthma Control

Start date: January 1, 2018
Study type: Observational

The purpose of the study is to explore the value which cough rate might provide for asthma self-management. In this study, the focus will be specifically on nocturnal cough rate. The plan is to use a longitudinal study design, in order to investigate to which extent trends in the nocturnal cough rates might have meaningful implications for future asthma control and asthma exacerbations of patients. The incidence of nocturnal cough in asthmatics will be described and visualized over the course of one month in the first stage of the study. Additionally, the aim will be to identify and model trends in nocturnal cough rates. Measuring cough is very time-consuming. Currently, there are no cough frequency monitors available, which measure cough rates in a fully automated and unobtrusive way. Consequently, manual labeling of cough based on video or sound recordings is still considered to be the gold standard for measuring cough rates by medical guidelines. Recently, a machine learning algorithm was successfully designed to automatically detect cough in a proof of concept study. This machine learning algorithm will be further developed in order to provide robust results in the field. The focus of this study will be the cough during the night time due to the limited interfering noise, which greatly facilitates manual labeling and enables a more reliable detection rate of the machine learning algorithm. Apart from developing a machine learning algorithm for cough detection, data will be gathered for the assessment of patient's sleep quality based on data obtained from smartphone's sensors.

NCT ID: NCT03630432 Recruiting - Asthma Clinical Trials

Pulmonary Rehabilitation for Uncontrolled Asthma Associated With Elevated BMI

Start date: May 11, 2017
Phase: N/A
Study type: Interventional

Aim to evaluate the impact of a pulmonary rehabilitation (rehab) programme tailored and delivered to overweight and obese patients with difficult asthma on: 1. Asthma related quality of life (primary outcome) and asthma control (secondary outcome) 2. Treatment burden and healthcare usage (secondary outcomes) 3. Physical activity level, exercise tolerance, lung function and inflammation (secondary outcome) 4. Anxiety and depression (secondary outcome)

NCT ID: NCT03629249 Not yet recruiting - Asthma Clinical Trials

Systemic Corticosteroids Avoidance Study in Severe Asthma Patients

Start date: December 7, 2018
Phase: Phase 4
Study type: Interventional

The overall purpose of this study is to determine the efficacy of fevipiprant (dose 1 and dose 2 once daily), compared with placebo, as add-on to standard-of-care asthma therapy, in terms of avoidance of coricosteroid use over 52 weeks.

NCT ID: NCT03627689 Recruiting - Asthma Clinical Trials

Molekule for Allergic Rhinitis/Asthma

Start date: July 13, 2018
Phase: N/A
Study type: Interventional

Exposure to airborne allergens and pollutants is linked to symptom severity of allergies, asthma and other respiratory problems. In this study an air purifier using photo-electrochemical oxidation technology (PECO) will be used in the home environment of study participants. The investigator will assess the reduction of symptoms from allergic rhinitis/conjunctivitis and asthma.

NCT ID: NCT03622112 Not yet recruiting - Asthma Clinical Trials

A Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD7594 Administered Once Daily by Inhalation in Asthmatic Subjects

Start date: October 12, 2018
Phase: Phase 2
Study type: Interventional

This study will assess the efficacy and safety of multiple dose levels of AZD7594 administered once daily (QD) by inhalation in a 12-week treatment period on asthma subjects. The activity will be assessed by comparing AZD7594 to placebo. The comparison between active comparator (FF) and placebo will be used for bench marking. The efficacy is assessed by the evaluation of change in trough forced expiratory volume in 1 second (FEV1). The aim is to develop AZD7594 as a once daily inhaled non-steroidal selective GR modulator (SGRM), which may ultimately lead to better disease control of both chronic obstructive pulmonary disease (COPD) and asthma through improved efficacy and compliance. The overall rationale for developing a once daily AZD7594 in a dry powder inhaler (DPI) is to provide a safe and effective future treatment option for both asthma and COPD subjects.

NCT ID: NCT03620747 Not yet recruiting - Asthma Clinical Trials

Continuation of TRAVERSE- LTS12551 Evaluating Dupilumab Safety in Patients With Asthma (Long-Term Follow-Up)

Start date: August 31, 2018
Phase: Phase 3
Study type: Interventional

Primary Objective: To describe the long-term safety of dupilumab in treatment of patients with moderate to severe asthma who completed the previous asthma clinical trial (TRAVERSE-LTS12551).

NCT ID: NCT03620422 Not yet recruiting - Asthma Clinical Trials

Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma

Start date: August 2018
Phase: N/A
Study type: Interventional

The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke coughing reproducibly in mild allergic asthmatics compared with healthy controls and if salbutamol can affect this. Phase 1 of this study is a reproducibility analysis of cough dose response to mannitol in a cohort of mild allergic asthmatics and healthy controls. Phase 2 is a double-blind, placebo-controlled analysis in mild allergic asthmatics assessing the effects of salbutamol on mannitol induced cough.

NCT ID: NCT03617718 Not yet recruiting - Healthy Clinical Trials

Project 2 Airway Potential Hydrogen (pH) in Asthma

Start date: September 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This study is testing a non invasive way to measure airway pH in individuals with Asthma and Cystic Fibrosis using a new inhaled drug. The airway pH will help health care providers in creating tailored treatment plans for individuals suffering from these specific conditions.

NCT ID: NCT03615248 Not yet recruiting - Asthma Clinical Trials

Effectiveness of a Mobile Health Intervention in Improving the Technique of Inhaled Medications Among Children With Asthma

Start date: September 10, 2018
Phase: Early Phase 1
Study type: Interventional

In this trial, the investigators aim to determine if a new mobile health intervention (BreatheSuite) can increase inhaler technique and adherence amongst participants aged 10-18. See the below detailed description for more information.

NCT ID: NCT03613675 Not yet recruiting - Asthma Clinical Trials

Acceptability of Video Games to Promote Asthma Education and Self-management in Children

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Asthma is a chronic lung disease affecting over 800,000 Canadian children. Knowing how to avoid asthma triggers, to take care of one's health, and to know when and why to do one's treatment can help prevent asthma crises, and have a better quality of life. Games in health can make the management of asthma easier by helping the child better understand his condition, his triggers, and manage his asthma by himself. Games also offer a personalized experience, where players can receive feedback about their learning. However, few studies explored the use of games in childhood asthma. This study will test 4 games for children with asthma. Through different characters and scenarios, the goals of the games are to help the child with asthma to better recognize and manage his asthma triggers and symptoms. The objectives of this study are: - Evaluate the acceptability of these games in children with asthma - Gather feedback on the games to guide future development