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NCT ID: NCT00096746 Completed - HIV Infection Clinical Trials

Effect of the Atazanavir (ATV) 150L Mutation on Subsequent Treatment Response in HIV Infected Subjects

Start date: November 2004
Phase: N/A
Study type: Observational

This study will compare the response of subjects who failed a first-line ATV-containing regimen and who have the 150L-containing virus to subsequent protease inhibitor (PI)-containing therapy with that of a cohort who has failed a first-line reverse transcriptase inhibitor (NNRTI), and is subsequently receiving PI-containing therapy.

NCT ID: NCT00095524 Completed - Schizophrenia Clinical Trials

Effects of Aripiprazole in Overweight Patients Treated With Olanzapine for Schizophrenia or Schizoaffective Disorder

Start date: March 2004
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to compare the affects of aripiprazole and olanzapine on weight change.

NCT ID: NCT00095238 Completed - Clinical trials for Congestive Heart Failure

Irbesartan in Heart Failure With Preserved Systolic Function (I-Preserve)

Start date: June 2002
Phase: Phase 3
Study type: Interventional

The purpose of this clinical research study is to learn if Irbesartan is superior to placebo in reducing mortality and cardiovascular morbidity in subjects with heart failure with preserved systolic function. The safety of this treatment will also be studied.

NCT ID: NCT00095173 Completed - Clinical trials for Juvenile Rheumatoid Arthritis

BMS-188667 in Children and Adolescents With Juvenile Rheumatoid Arthritis

Start date: February 2004
Phase: Phase 3
Study type: Interventional

The primary purpose of the clinical research study is to assess the safety of treating children and juvenile subjects with BMS-188667 (Abatacept). In addition, the study will assess the effectiveness of BMS-188667 in reducing disease activity of Juvenile Rheumatoid Arthritis (JRA) or Juvenile Idiopathic Arthritis (JIA) as measured by the time to occurrence of disease flare.

NCT ID: NCT00095147 Completed - Clinical trials for Rheumatoid Arthritis

Abatacept and Infliximab in Combination With Methotrexate in Subjects With Rheumatoid Arthritis

Start date: February 2005
Phase: Phase 3
Study type: Interventional

The purpose of this clinical research study is to learn if Abatacept or Infliximab in combination with Methotrexate demonstrate a greater reduction in disease activity over placebo.

NCT ID: NCT00095030 Completed - Clinical trials for Diabetes Mellitus, Type 2

Study Comparing Muraglitazar With Glimepiride in Type 2 Diabetics Who Are Not Controlled With Metformin Alone

Start date: February 2004
Phase: Phase 3
Study type: Interventional

The purpose of this clinical research study is to learn whether a muraglitazar-metformin combination is at least as effective as a glimepiride-metformin combination to treat type 2 diabetics who are not sufficiently controlled with metformin alone. The safety of this treatment will also be studied.

NCT ID: NCT00094653 Completed - Melanoma Clinical Trials

MDX-010 Antibody, MDX-1379 Melanoma Vaccine, or MDX-010/MDX-1379 Combination Treatment for Patients With Unresectable or Metastatic Melanoma

Start date: September 2004
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the safety and efficacy of MDX-010 (ipilimumab, BMS-734016) (anti-CTLA4) in combination with MDX-1379 (gp100, BMS-734019) in patients with previously treated, unresectable Stage III or IV melanoma. Survival time will be evaluated, as well as patient responses and time to disease progression. Eligible patients are those who in response to a single regimen containing interleukin-2 (IL-2), dacarbazine, and/or temozolomide, have 1) relapsed following an objective response (partial response/complete response [PR/CR]); 2) failed to demonstrate an objective response (PR/CR); or 3) could not tolerate such a regimen due to unacceptable toxicity. Patients will be randomized into one of three groups, and will receive one of the following treatments: MDX-010 alone, MDX-1379 alone, or MDX-010 in combination with MDX-1379.

NCT ID: NCT00094640 Completed - Schizophrenia Clinical Trials

Pharmacokinetic Characterization of Intramuscular Olanzapine Depot

Start date: n/a
Phase: Phase 1
Study type: Interventional

The goals of this study are to: Determine the blood levels of intramuscular (IM) olanzapine depot in patients at different points in time after an injection, and compare these levels to the amount of olanzapine in the blood of patients after treated by oral administration with Zyprexa (olanzapine) tablets or by intramuscular administration with Zyprexa IntraMuscular (olanzapine for injection).

NCT ID: NCT00094302 Completed - Clinical trials for Cardiovascular Diseases

Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function

TOPCAT
Start date: August 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effectiveness of aldosterone antagonist therapy in reducing cardiovascular mortality, aborted cardiac arrest, and heart failure hospitalization in patients who have heart failure with preserved systolic function.

NCT ID: NCT00093002 Completed - Breast Cancer Clinical Trials

Fulvestrant (FASLODEX™) as a Treatment in Postmenopausal Women With Estrogen Receptor Positive Breast Cancer

Start date: June 2004
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate fulvestrant in the preliminary stage of breast cancer treatment and assess the relationship between dose, exposure, degree of reduction in tumor markers, and efficacy in postmenopausal women with estrogen receptor positive disease.