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NCT ID: NCT00528879 Completed - Type 2 Diabetes Clinical Trials

A Phase III Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes Who Are Not Well Controlled on Metformin Alone

Start date: September 2007
Phase: Phase 3
Study type: Interventional

The purpose of this clinical research study is to learn whether dapagliflozin can help reduce blood sugar levels in participants with Type 2 diabetes that is not well controlled on metformin alone. The safety of this treatment will also be studied.

NCT ID: NCT00528567 Completed - Breast Cancer Clinical Trials

BEATRICE Study: A Study of Bevacizumab (Avastin) Adjuvant Therapy in Triple Negative Breast Cancer

Start date: December 2007
Phase: Phase 3
Study type: Interventional

The main objective of the trial is to compare Invasive Disease-Free Survival (IDFS) of patients randomised to treatment with adjuvant chemotherapy alone or to adjuvant chemotherapy with 1 year of bevacizumab. The secondary objectives of this trial are to: - compare Overall Survival (OS), Breast Cancer-Free Interval (BCFI), Disease- Free Survival (DFS) and Distant Disease-Free Survival (DDFS) of patients randomised to treatment with adjuvant chemotherapy alone or to adjuvant chemotherapy in combination with 1 year of bevacizumab - evaluate the safety and tolerability of bevacizumab An exploratory sub-study (not reported here) was to identify biomarkers (from tumour or serum) predictive of toxicity and for the level of benefit from the addition of bevacizumab to standard adjuvant systemic treatment.

NCT ID: NCT00528112 Completed - Contraception Clinical Trials

Levonorgestrel Contraceptive Intrauterine Systems (LCS) Pearl Index Study

Start date: August 2007
Phase: Phase 3
Study type: Interventional

This is a study on a new low dose levonorgestrel contraceptive intrauterine systems (LCS). The purpose of the study is to investigate which of the 2 administered doses is the lowest effective intrauterine dose of Levonorgestrel (LNG) administered via the LCS for contraception during 3 years. The study was amended: the LCS16 arm will be extended up to 5 years

NCT ID: NCT00525824 Completed - Atherosclerosis Clinical Trials

12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTORâ„¢) in Combination With Ezetimibe

GRAVITY
Start date: August 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether treatment of Rosuvastatin (CRESTORâ„¢) or Simvastatin given as monotherapy or given in combination with Ezetimibe, will lower the Low Density Lipoprotein Cholesterol (LDL-C) in patients with Hypercholesterolaemia and Coronary Heart Disease (CHD) or a CHD Risk Equivalent, Atherosclerosis or a 10-year CHD Risk of >20%

NCT ID: NCT00525512 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Tiotropium In Exercise

Start date: August 2007
Phase: Phase 4
Study type: Interventional

The objective of this study is to evaluate the effects on exercise duration of 96 weeks treatment with 18 mcg tiotropium (Spiriva HandiHaler) daily as compared to placebo, in patients with COPD.

NCT ID: NCT00524368 Completed - Clinical trials for Human Immunodeficiency Virus - Type 1

A Study to Compare Effectiveness and Safety of Darunavir/Ritonavir (DRV/Rtv) 800mg/100mg Once Daily Versus DRV/Rtv 600mg/100mg Twice Daily in Early Treatment-Experienced HIV-1 Infected Patients (ODIN)

ODIN
Start date: October 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to test if being treated with darunavir/ritonavir (DRV/rtv) 800/100 mg daily is as effective as being treated with DRV/rtv 600/100 mg twice daily, in early antiretroviral (ARV)-experienced patients when given along with selected optimized background regimen (OBR).

NCT ID: NCT00523497 Terminated - Clinical trials for Acute Hypoxemic Respiratory Failure

Efects of Noninvasive Mechanical Ventilation and Conventional Mechanical Ventilation in Patients With Severe Comunity Pneumonia

NIMV AND SCAP
Start date: n/a
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the noninvasive ventilation is more effective in the treatment of severe comunity acquired pneumonia in comparison with the conventional mechanical ventilation with orotracheal intubation.

NCT ID: NCT00522873 Completed - Postmenopause Clinical Trials

Endometrial Safety Study

Start date: August 2007
Phase: Phase 3
Study type: Interventional

The study is designed to investigate the safety of the investigational product for the lining of the uterus (endometrium).

NCT ID: NCT00520923 Completed - Schizophrenia Clinical Trials

A Study for Patients With Schizophrenia

Start date: September 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test the hypothesis that 1 or more dose levels of LY2140023 given orally to patients with schizophrenia twice daily for 4 weeks will have significantly greater effect than placebo.

NCT ID: NCT00520780 Completed - Clinical trials for Chronic Heart Failure

Ferinject® Assessment in Patients With Iron Deficiency and Chronic Heart Failure (FAIR-HF)

FAIR-HF
Start date: April 2007
Phase: Phase 3
Study type: Interventional

This study is designed to evaluate the efficacy of Ferinject® in improving symptoms of CHF in patients with iron deficiency. Analyses will focus both on subjective and objective measures. Furthermore, the tolerability and safety of Ferinject® treatment will be evaluated.