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Cancer clinical trials

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NCT ID: NCT00447226 Terminated - Cancer Clinical Trials

Randomized Discontinuation Study of Lapatinib Versus Placebo in Subjects With Documented Tumor Progression After Chemotherapy, or Where no Approved Therapy Exists

Start date: May 2007
Phase: Phase 2
Study type: Interventional

This study will examine the efficacy and safety of lapatinib in patients with ErbB2 positive ovarian, gastric/esophageal adenocarcinoma, uterine serous papillary, or bladder cancers.

NCT ID: NCT00444093 Terminated - Cancer Clinical Trials

Prospective Randomized Open Label Study of the Treatment of Therapy-associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium -

Loop
Start date: March 5, 2007
Phase: Phase 3
Study type: Interventional

Therapy-associated diarrhea during radiation therapy of small pelvis (including enteritis as a result of radiation therapy and enteritis as a result of radiation- and chemotherapy) is a common problem in multimodal cancer therapy. We investigate the therapeutic effect of either loperamide or tinctura opii in therapy- associated diarrhea in patients who receive radiation therapy of the small pelvis with or without chemotherapy.

NCT ID: NCT00423683 Terminated - Cancer Clinical Trials

Anticoagulation and Inferior Vena Cava Filters in Cancer Patients With a Venous Thromboembolism

Start date: January 2007
Phase: Phase 3
Study type: Interventional

The development of clots is a potentially deadly complication in many cancer patients. The current optimal treatment is unknown. Evidence supporting the effectiveness of the use of Inferior Vena Caval Filters is lacking. This study will compare the two standard of care treatment options: anticoagulation with or without a inferior vena cava filter. The anticoagulation medication chosen will be Arixtra and it will be given once a day as an injection. Patients will be called at various intervals to monitor their signs and symptoms of new thromboembolisms.

NCT ID: NCT00398840 Terminated - Cancer Clinical Trials

A Study of ARQ 171 in Patients With Advanced Solid Tumors

Start date: November 2006
Phase: Phase 1
Study type: Interventional

This is an open label, dose escalation study of ARQ 171 administered via intravenous infusion (IVI) into a peripheral vein weekly. Patients with advanced solid tumors, who are refractory to available therapy or for whom no standard systemic therapy exists, will be enrolled.

NCT ID: NCT00387153 Terminated - Cancer Clinical Trials

Phase 1 Clinical Trial MPC-2130 Treatment of Blood Cancers / Refractory Cancer

Start date: August 2005
Phase: Phase 1
Study type: Interventional

Phase 1 Open-label treatment with MPC-2130 for subjects with refractory cancer.

NCT ID: NCT00386152 Terminated - Cancer Clinical Trials

A Study Comparing Two Different PROCRIT Doses to a Dose of ARANESP in Anemic Cancer Patients Receiving Chemotherapy

Start date: November 2006
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare hemoglobin response rates between two PROCRIT (epoetin alfa) doses and ARANESP (darbepoetin alfa) in anemic cancer patients receiving chemotherapy

NCT ID: NCT00381095 Terminated - Cancer Clinical Trials

A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer

COPE
Start date: December 2006
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the analgesic efficacy of flexibly-dosed pregabalin in the adjunctive treatment of subjects with cancer-induced bone pain.

NCT ID: NCT00358111 Terminated - Cancer Clinical Trials

Study of LUMA Cervical Imaging System as Adjunct to Colposcopy

Start date: July 2006
Phase: Phase 4
Study type: Interventional

This is a post-approval, multi-center, single-arm study (n=950) designed to address the relationship of the LUMA device performance to patient age, patient human papillomavirus (HPV) status and colposcopist experience.

NCT ID: NCT00351715 Terminated - Pain Clinical Trials

Sublingual Methadone for the Management of Cancer-related Breakthrough Pain in Outpatients

Start date: July 2008
Phase: Phase 2
Study type: Interventional

The purpose of this Phase II study is to determine the feasibility of the dose titration and assessment protocol in the outpatient population before conducting an appropriately powered phase III study. Thus the primary purpose of this study is to determine the proportion of patients who are successfully titrated to an optimal dose of sublingual (Under the tongue) methadone and then studied at that optimal dose with successive episodes of breakthrough pain.

NCT ID: NCT00351637 Terminated - Pain Clinical Trials

Sublingual Methadone for the Management of Cancer-related Procedure Pain in Inpatients

Start date: December 2006
Phase: Phase 2
Study type: Interventional

The purpose of this Phase II study is to determine the feasibility of the dose titration and assessment protocol in the impatient population, in the clinical setting of preventing or managing breakthrough pain, before conducting an appropriately powered phase III study. Thus the primary purpose of this study is to determine the proportion of patients who are successfully titrated to an effective dose of sublingual methadone.