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Cancer clinical trials

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NCT ID: NCT03581357 Not yet recruiting - Cancer Clinical Trials

Online and Mobile Mindfulness Intervention to Improve the Well-Being of Cancer Survivors

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

Evaluate the impact and satisfaction of Online Mindfulness Meditation (OMM) on anxiety, pain, fatigue, trauma, and sleep in cancer survivors.

NCT ID: NCT03577002 Not yet recruiting - Cancer Clinical Trials

Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP. Discussion and planning for serious illness care can help patients identify what is most important to them and assure they receive care that best matches their goals and values, such as spending more time at home or not being in pain.

NCT ID: NCT03570229 Not yet recruiting - Cancer Clinical Trials

Hyperbaric Oxygenation Treatment and Quality of Life

Start date: August 6, 2018
Phase:
Study type: Observational

Osteoradionecrosis, dermal soft tissue necrosis, radiation cystitis, proctitis and sexual dysfunctions are well-known late-effects after radiation for cancer in the pelvic area, negatively affecting the survivors' quality of life (QOL) and psychosocial wellbeing. Increasing evidence and clinical practice support the use of hyperbaric oxygen treatment (HBOT) as an effective treatment in a variety of radiation injuries, but this is still a field with limited research and knowledge. Especially, there is a knowledge gap on how late radiation tissue injury (LRTI) influences cancer survivors' QOL and psychosocial health in a longitudinal perspective (before, along and after HBOT), as well as the patients' knowledge, expectation and experience from this treatment. This study aims to improve knowledge on these issues.

NCT ID: NCT03569605 Not yet recruiting - Cancer Clinical Trials

Promoting Physical Activity in Young Adult Cancer Survivors Using mHealth and Adaptive Tailored Feedback Strategies

IMPACT
Start date: July 2018
Phase: N/A
Study type: Interventional

To date, few interventions have been designed specifically to promote physical activity in young adult cancer survivors, nor used novel technologies for delivery; none have been successful in promoting long-term adherence to PA. The purpose of this randomized controlled trial is to test the efficacy of a theory-based, mobile physical activity intervention with adaptive goal-setting and tailored feedback that is aimed at increasing physical activity among young adult cancer survivors.

NCT ID: NCT03564548 Not yet recruiting - Cancer Clinical Trials

Inhaled Cannabis Versus Fentanyl Buccal Tablets for Management of Breakthrough Pain in Cancer Patients

Start date: September 1, 2018
Phase: Phase 2
Study type: Interventional

Breakthrough cancer pain (BTcP) is a rapid onset, high intensity and short duration pain episode, which takes place within a stable background pain control. It significantly affects the quality of life of oncologic patients and their ability to function normally. Rapid onset opioids are the standard treatment for BTcP, and the various fentanyl transmucosal formulations (FTF) are among the best examples of these treatments. However, the limited availability, the high cost, the complicated titration and the high risks of overdosing of FTF greatly challenge their use. In order to seek a potential alternative to FTF, the investigators are proposing to compare inhaled medical cannabis (PPP001) to FBT or placebo on relieving BTcP intensity in cancer patients.

NCT ID: NCT03563924 Not yet recruiting - Cancer Clinical Trials

Allo - Cancer - Thrombosis

AlloTC
Start date: June 2018
Phase:
Study type: Observational

Management of venous thromboembolism (VTE) in patients with cancer is complex and require the intervention of many specialized health professionals, in hospital but also at home and during follow-up. The AlloTC project aims to integrate the management of VTE within the multidisciplinary care pathway of the patient with cancer, in order to improve the management of VTE in patients with cancer: optimize treatments and follow-up with appropriate anticoagulants, monitor the implementation of good clinical practice, promote patient involvement and adherence. The objective of this monocentric study is to evaluate the efficiency of the integration of the therapeutic management of VTE into a specific management of patient with cancer and to set up a specialized "AlloTC" team that coordinates this course of care. For that purpose, the management of VTE and outcome of patients with cancer and VTE will be compared between two periods : traditional management and management with the "AlloTC" team.

NCT ID: NCT03557762 Not yet recruiting - Cancer Clinical Trials

The SEAMLESS Study: Smartphone App-based Mindfulness for Cancer Survivors

Start date: July 16, 2018
Phase: N/A
Study type: Interventional

Smartphone app-based health interventions are an innovative way to deliver psychosocial cancer-care. In the SEAMLESS study, the investigators aim to evaluate a 4 week smartphone app-based mind-body intervention (MBI) in cancer survivors post-treatment. This is a randomized controlled trial, with a waitlist control group. Participants will be assigned to either receive the intervention immediately after enrollment or will need to wait for 3 months to receive the intervention.

NCT ID: NCT03556384 Not yet recruiting - Cancer Clinical Trials

Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor

Start date: August 2018
Phase: Phase 2
Study type: Interventional

FDA-approved products for patients with unresectable or metastatic GIST include therapies such as imatinib and sunitinib. Although there are FDA-approved products for the treatment of advanced/metastatic GIST, these therapies are known to be ineffective in the SDH-mutant/deficient subtype and no known effective therapies exist. The purpose of this study is to investigate SDH-Mutant/Deficient Gastrointestinal Stromal cancer's response to the drug Temozolomide (TMZ) and aim to improve patient outcomes. Temozolomide is approved by the FDA for the treatment of newly diagnosed glioblastoma multiforme (GBM) and refractory anaplastic astrocytoma cancers. Temozolomide is considered experimental because it is not approved by the FDA for the treatment of SDH-Mutant/Deficient Gastrointestinal Stromal Tumor.

NCT ID: NCT03543358 Not yet recruiting - Cancer Clinical Trials

A Long-Term Study of Rovalpituzumab Tesirine

Start date: August 19, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this long-term, extension study is to provide ongoing safety and efficacy follow-up of subjects who participated in a rovalpituzumab tesirine study that has completed the primary analysis and that is closing.

NCT ID: NCT03539835 Not yet recruiting - Cancer Clinical Trials

Resistance Training to Improve Fatigue and Physical Function in Postmenopausal Breast Cancer Survivors

Start date: August 2018
Phase: N/A
Study type: Interventional

This study will begin to fill a knowledge gap by determine whether changes in kynurenine metabolism occur following Resistance Training (RT) and relate to reductions in inflammation and improved behavioral and physical function as this may identify potential targets for interventions to promote cancer recovery.