There are more than 498,563 clinical trials published worldwide with over 60,000 trials that are currently either recruiting or not yet recruiting. Use our filters on this page to find more information on current clinical trials or past clinical trials (free or paid) for study purposes and read about their results.
Left ventricular (LV) lead position has crucial impact on cardiac resynchronization therapy (CRT) success. This study will compare fluoroscopy and myocardial deformation imaging for optimal definition of LV lead position.
Chronic musculoskeletal pain is a major problem in society. Treatments for people with musculoskeletal pain have limited efficacy. Transcutaneous Electrical Nerve Stimulation (TENS) is a commonly utilized, non-invasive treatment for pain that is a safe non-pharmacological treatment that has been utilized for treatment of musculoskeletal pain. Recent studies in animals in the PIs laboratory have begun to examine the mechanism of action of TENS. The current study is proposed to translate the findings from the animals to human subjects. One concern with TENS is that there is not an appropriate placebo. Since TENS delivers an electrical current through the skin to produce pain relief, patients can typically feel the stimulation under the electrodes. The standard placebo in prior clinical studies has been to utilize a unit that appears to be functioning (lights on) but does not deliver a current. In this case the subject would not feel the stimulation. We will compare this standard placebo to a new device in which a current is delivered for 30 seconds and then slowly ramps to off. This current would then be felt by the subject as intensity is set, and then would slowly ramp down. Thus, electrical currents will be felt by the subject. It is common for people to adapt to the TENS current so that they no longer feel the stimulation over time, or that the stimulation is felt at a lower intensity. This new placebo TENS would appear to mimic this event to the subjects. This new TENS would have the further advantage of being able to double-blind the study so that the therapist applying the treatment, and the subject receiving the treatment are unaware who is receiving the active treatment. The investigators will therefore test the adequacy of this placebo when compared to a standard placebo with no stimulation. Hypotheses: 1. TENS will reduce temporal summation and increase nociceptive threshold in normal subjects 2. Placebo TENS with a short burst of electrical stimulation will be considered by subjects to be an active TENS unit with a greater frequency than the standard TENS unit that does not produce electrical current 3. effectiveness of TENS will be associated with genotype of candidate pain genes (SNPs).
The purpose of this study is to compare the effects on visual development, growth, cognitive development, tolerance, and blood chemistry parameters in term infants fed one of four study formulas containing various levels of DHA and ARA.
Evaluation of the effect of fluticasone propionate vs placebo applied as nasal spray on the increase of allergen-specific serum IgE levels following nasal exposure to recombinant allergens. Nasal sprays will be applied for four weeks starting two weeks before nasal provocation and serum IgE levels will be followed during eight weeks after nasal provocation.
The objective of this trial is to determine the effect of different lifestyle interventions such as aerobic exercise and alternative resistance training methods, combined with a hypocaloric diet, on weight, body composition and metabolic risk factors in overweight and obese adults.
The hypothesis of this study proposal is that pediatric urinary stone formers have genetic risk factors which predispose their urinary stone production. 50-60% of pediatric stone patients have a positive family history of urinary stone disease. Several genetic mutations have been identified which predispose patients to various types of urinary stones. These genetic mutations can also lead to other significant sequela besides stones, including osteopenia/osteoporosis (bone loss). Furthermore, metabolic abnormalities can be identified in more than 50% of pediatric stone formers, some of which can be improved and/or alleviated with medical intervention to help decrease rate of stone formation and the need for hospitalization and surgical intervention.
RATIONALE: Patient abstract not available PURPOSE: Patient abstract not available
RATIONALE: Patient abstract not available PURPOSE: Patient abstract not available
Increased intake of dietary fibre and whole grains is related to reduced risk of developing diabetes. The term "whole grain" is often used for whole-meal products in which the structure of the cereal grain is destroyed in the flour containing the original dietary fiber, but also for cereal products in which a large proportion of whole cereal grains is intact. The aim of this study was to evaluate the effect of commercial rye whole-meal bread (RWMB) compared to white-wheat bread (WWB) on gastric emptying rate (GER), postprandial glucose response in healthy subjects.
The main purpose of our study was to which determine factors, those measured by ultrasound and also demographic and clinical factors (age, number of previous pregnancies, abortions and deliveries) predict outcome of medical treatment for early pregnancy failure. Our hypothesis was that gestational sac volume predicts outcome of medical treatment for early pregnancy failure.