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Abortion, Spontaneous clinical trials

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NCT ID: NCT05449171 Completed - Clinical trials for Abortion, Spontaneous

High Molecular Weight Hyaluronic Acid, α-lipoic Acid, Magnesium, Vitamin B6 and Vitamin D, in the Prevention of Spontaneous Abortion

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

The study aims to verify if the association of high molecular weight hyaluronic acid, α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D, reduces the risk of miscarriage in patients at risk.

NCT ID: NCT05437471 Completed - Clinical trials for Miscarriage, Recurrent

Effects of Co-treatment on Endometrial abv3-integrin Expressions in Women With Recurrent Implantation Failure

Start date: January 1, 2020
Phase: N/A
Study type: Interventional

To compare the abv3-integrin expression in endometrium tissue among RIF women between the GnRH analogue with Aromatase Inhibitor (Group A) , GnRH analogue with progesterone (Group B) and GnRH analogue alone as control group (Group C)

NCT ID: NCT05342948 Completed - Clinical trials for Recurrent Pregnancy Loss

Association of HY-restricting HLA Class II Alleles, Sex of Firstborn Child, and Pregnancy Outcome in RPL Patients

Start date: January 1, 2016
Phase:
Study type: Observational [Patient Registry]

This cross-sectional and prospective cohort study will investigate if sRPL patients with a first born boy who carry ≥1 HY-restricting (HY-r) HLA class II alleles are associated with a lower chance for a succesful reproductive outcome in first pregnancy after admission compared to sRPL patients with a first born girl carrying ≥1 HY-r HLA class II alleles and women with no HY-r HLA class II alleles and a firstborn boy. Also, the study will compare sRPL patients with a firstborn boy who do not carry a HY-r HLA class II allele with sRPL patients having a firstborn girl and carrying no such alleles. We hypothesize that sRPL patients with a first born boy compared to sRPL patients with a firstborn girl who carry ≥1 HY-r HLA class II alleles is associated with a negative prognosis, while no association between sex of firstborn child and pregnancy outcome is expected in sRPL carrying no HY-r HLA class II alleles. Neither do we expect an association between pregnancy outcome and carriage of HY-r HLA class II alleles in pRPL patients.

NCT ID: NCT05216952 Completed - Missed Abortion Clinical Trials

Ulipristal Acetate for Use in Early Pregnancy Loss

Start date: May 11, 2022
Phase: Phase 2
Study type: Interventional

The investigators will study the feasibility of using 90mg ulipristal acetate, a selective progesterone receptor agonist, as an adjunct to 800mcg vaginal misoprostol for the medical management of early pregnancy loss. Patients will be followed to assess effective treatment of early pregnancy loss, additional interventions needed, side effects, adverse events and patient acceptability.

NCT ID: NCT05205044 Completed - Clinical trials for Recurrent Pregnancy Loss

Evaluation of Apelin-13 and Apelin-36 in Women With Recurrent Pregnancy Loss

Start date: January 23, 2022
Phase:
Study type: Observational

Lower Apelin levels are associated with hypertensive disorders with pregnancy, yet no studies investigated its levels in recurrent pregnancy loss

NCT ID: NCT05073978 Completed - Preterm Birth Clinical Trials

B-vitamin Levels and Adverse Pregnancy Outcomes

Start date: December 1, 2020
Phase:
Study type: Observational

This prospective nested case-control study aims to examine the effects of blood vitamin B levels in first-trimester pregnant women on the pregnancy outcomes

NCT ID: NCT05049980 Completed - Clinical trials for Pregnancy Loss, Early

Patient Satisfaction With the Management of a Stopped Pregnancy in the First Trimester

MYFEFACY
Start date: November 1, 2021
Phase: N/A
Study type: Interventional

The clinical practice recommendations highlight the fact that the patient's choice concerning the management of her aborted pregnancy in the first trimester should be privileged, after clear and appropriate information on the available treatments, in order to improve his experience and reduce the negative psychological symptoms that can generate an alteration in the quality of life, in the aftermath of the loss of pregnancy. The present study will describe the efficacy, satisfaction and tolerance of patients benefiting from medical treatment with Mifégyne® and MisoOne® versus those benefiting from surgical treatment by endo-uterine aspiration for the management of a pregnancy stopped during the first trimester at the Toulouse University Hospital

NCT ID: NCT04960982 Completed - Clinical trials for Polycystic Ovary Syndrome

Changes in Pregnancy in Egyptian Women With History of Recurrent Miscarriage

Start date: March 1, 2018
Phase:
Study type: Observational [Patient Registry]

Introduction: Elevated levels of androgen and insulin-resistant have been implicated in recurrent miscarriage in women with PCOS. Published data are scarce on androgen level and cervical length of women with and without PCOS and a history of miscarriage. Aim: The aim of this study was to investigate the levels of testosterone (TT), Sex Hormone Binding Globulin (SHBG), Dehyroepiandrostenedione (DHEA) and cervical length in Egyptian women with and without history PCOS and history of RM during pregnancy . Method: Pregnant women with (n=38) and without (n=40) PCOS and history of recurrent miscarriages were recruited from the Obstetrics Department, Alagoza Hospital, Cairo, Egypt. Healthy pregnant women without PCOS and history of RM (n=40, HC) were also recruited. TT, SHBG,DHEA and Sex Hormone Binding Globulin (SHBG) level and cervical length were assessed at first, second and the third trimester or at the start of miscarriage

NCT ID: NCT04910958 Completed - Covid19 Clinical Trials

Impact of COVID-19 Pandemic on Early Spontaneous Abortions and Early Termination of Pregnancy

Start date: January 6, 2021
Phase:
Study type: Observational

To see the impact the COVID-19 pandemic has had on early spontaneous abortions and early termination of pregnancy in the first trimester

NCT ID: NCT04841486 Completed - Pregnancy Clinical Trials

First Trimester of Pregnancy: Impact of a History of Miscarriage on Women's Stress

Stress-FC
Start date: June 11, 2021
Phase:
Study type: Observational

Miscarriage is the spontaneous termination of pregnancy before 22 weeks of amenorrhea. The most frequent complication of pregnancy, it represents 10 to 25% of pregnancies and affects one in four women. Miscarriage is considered by medical personnel to be common and trivial. however, for women, it is very often a traumatic event, a source of worry for futures pregnancies.