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Abortion, Spontaneous clinical trials

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NCT ID: NCT05365464 Withdrawn - Clinical trials for Recurrent Pregnancy Loss Without Current Pregnancy

HOPE Trial hCG or Progesterone Effect on Recurrent Pregnancy Loss

HOPE
Start date: May 2022
Phase: Phase 2
Study type: Interventional

Up to half of all cases of recurrent pregnancy loss are unexplained (uRPL). Evidence points towards endometriosis and progesterone resistance as an underlying cause of uRPL. Previous non-RCT studies have suggested the luteal hCG provides a useful treatment for uRPL. We propose performing a randomized controlled trial to compare mid-luteal hCG with oral progesterone to prevent early pregnancy losses. the endpoint will be ongoing pregnancy and live birth rates. Equal numbers of patients will be randomized to each group.

NCT ID: NCT05168865 Withdrawn - Miscarriage Clinical Trials

Letrozole Versus Hormonal Preparation in Frozen Cycles of PCOS Patients.

Start date: August 1, 2023
Phase: Phase 4
Study type: Interventional

One of the indications of freezing is to reduce the risk of ovarian hyperstimulation syndrome particularly in polycystic ovarian disease (PCOS) women. Very few RCTs addressed the issue of optimizing the endometrium for a frozen cycle. Interestingly, Letrozole for ovarian stimulation showed significantly better reproductive outcome when compared with hormone replacement therapy (HRT) cycle. In addition, HRT cycle has been associated with higher miscarriage rate when compared with natural cycle frozen embryo transfer. Nevertheless, there is not yet a well-designed prospective randomized study comparing letrozole and HRT in PCOS women undergoing frozen embryo transfer.

NCT ID: NCT02379650 Withdrawn - Miscarriage Clinical Trials

Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss

Start date: July 2016
Phase: Phase 2
Study type: Interventional

Recurrent pregnancy loss (RPL) affects 5% of couples trying to achieve parenthood. Most cases of RPL are unexplained and have no effective treatment to improve the likelihood of a pregnancy resulting in a live birth. This leads to significant patient and provider frustration and emotional stress. Hydroxychloroquine (HCQ) is a medication commonly used in pregnancy to treat autoimmune and connective tissue diseases such as systemic lupus erythematosus (SLE). This use has shown that HCQ is very safe in pregnancy. HCQ has anti-inflammatory and anti-thrombotic effects and thus may improve pregnancy outcomes in couples with unexplained RPL. Although some providers are already prescribing HCQ for unexplained RPL, a randomized controlled trial is necessary to determine the true efficacy and safety of this treatment. This study has the potential to establish support for a new treatment option for unexplained RPL.

NCT ID: NCT02328742 Withdrawn - Infertility Clinical Trials

Development of a Bioabsorbable Medical Device for the Prevention of Postoperative Intra-uterine Adhesions.

PréSynUT-1
Start date: November 2015
Phase: N/A
Study type: Observational

The main objective of this study is to describe the level of expression of the biological factors involved in the formation of adhesions (Transforming growth factor beta, Activin A, inhibin) at the time of a first diagnostic hysteroscopy among women with synechia, another intracavitary disease or no intracavitary disease.

NCT ID: NCT01718340 Withdrawn - Abortion, Habitual Clinical Trials

Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia

MetRPL
Start date: June 2012
Phase: Phase 4
Study type: Interventional

The prevalence of insulin resistance is increased in women with recurrent miscarriage compared with matched fertile controls,Insulin resistance (IR) in this syndrome is not only implicated toward early pregnancy loss (EPL) but also pathognomic for various obstetrical complications during pregnancy.An elevated free androgen index appears to be a prognostic factor for a subsequent miscarriage in women with recurrent miscarriage. There is insufficient evidence to evaluate the effect of metformin supplementation in pregnancy to prevent a miscarriage in women with recurrent miscarriage.

NCT ID: NCT01679561 Withdrawn - Clinical trials for Pregnancy Complicated by Low Implantation

Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial

ILRIFRM
Start date: February 2012
Phase: Phase 4
Study type: Interventional

Both organ-specific and systemic autoimmunity are associated with an increased prevalence of recurrent miscarriage and reproductive failure, rendering the role of the maternal immunological system in fertility a key concept. It is believed by some that central to this theme is the maternal cytokine profile, with particularly T-helper (Th) cells. Immune modulating therapies have therefore been mooted as potential therapeutic strategies. Recent reports of high pregnancy rates achievable in women with RIF have added fuel to the debate regarding the effectiveness of intralipids in modulating the immune system.