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Polycystic Ovary Syndrome clinical trials

View clinical trials related to Polycystic Ovary Syndrome.

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NCT ID: NCT03951077 Not yet recruiting - Clinical trials for Polycystic Ovary Syndrome

Study of the Safety and Efficacy of Elagolix in Women With Polycystic Ovary Syndrome

Start date: June 22, 2019
Phase: Phase 2
Study type: Interventional

This study will assess the potential impact of Elagolix on disordered pituitary and ovarian hormones in women with Polycystic Ovary Syndrome (PCOS).

NCT ID: NCT03911297 Not yet recruiting - Clinical trials for Polycystic Ovary Syndrome

DAISy-PCOS Phenome Study - Dissecting Androgen Excess and Metabolic Dysfunction in Polycystic Ovary Syndrome

DAISy-PCOS
Start date: June 1, 2019
Phase:
Study type: Observational

Polycystic ovary syndrome (PCOS) affects 10% of all women and usually presents with irregular menstrual periods and difficulties conceiving. However, PCOS is also a lifelong metabolic disorder and affected women have an increased risk of type 2 diabetes, high blood pressure, and heart disease. Increased blood levels of male hormones, also termed androgens, are found in most PCOS patients. Androgen excess appears to impair the ability of the body to respond to the sugar-regulating hormone insulin (=insulin resistance). We found that fat tissue of PCOS patients overproduces androgens and that this can result in a build-up of toxic fat, which increases insulin resistance and could cause liver damage. In a large cohort of women registered in a GP database, we have found that androgen excess increases the risk of fatty liver disease. We aim to identify those women with PCOS who are at the highest risk of developing metabolic disease, which would allow for early detection and potentially prevention of type 2 diabetes, high blood pressure, fatty liver and cardiovascular disease. We will assess clinical presentation, androgen production and metabolic function in women with PCOS to use similarities and differences in these parameters for the identification of subsets (=clusters) of women who are at the highest risk of metabolic disease. We will do this by using a standardised set of questions to scope PCOS-related signs and symptoms and the patient's medical history and measure body composition and blood pressure. This standardised recording of a patient's clinical presentation (=clinical phenotype) is called Phenome analysis. We will collect blood and urine samples for the systematic measurement of steroid hormones including a very detailed androgen profile (=steroid metabolome analysis) and of thousands of substances produced by human metabolism (=global metabolome analysis). Phenome and metabolome data will then undergo integrated computational analysis for the detection of clusters predictive of metabolic risk.

NCT ID: NCT03905941 Not yet recruiting - Clinical trials for Polycystic Ovary Syndrome

Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age

Start date: April 1, 2019
Phase: Early Phase 1
Study type: Interventional

The goal of this study is to determine the relative desirability of metformin vs. oral combined hormonal contraceptives (OCs) in treating Polycystic Ovary Syndrome (PCOS) in women of later reproductive age. Polycystic Ovary Syndrome Questionnaire (PCOSQ) score will be used as a proxy for patient satisfaction. In light of their respective effects on the classic and metabolic facets of PCOS, metformin will provide non-inferior patient satisfaction compared to OCs in later reproductive age women with PCOS.

NCT ID: NCT03905603 Not yet recruiting - Clinical trials for Polycystic Ovary Syndrome

Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS

Start date: April 2019
Phase: Early Phase 1
Study type: Interventional

The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone [LH] secretion, ovarian response to recombinant human chorionic gonadotropin [r-hCG] administration, adrenal response to adrenocorticotropic hormone [ACTH] administration, and hyperinsulinemia) in older vs. young women with Polycystic Ovary Syndrome (PCOS) in a cross-sectional, physiological study. The investigators hypothesize that hyperinsulinemia is a stronger independent predictor of free testosterone (T) in older reproductive aged (vs. young) women with PCOS.

NCT ID: NCT03902327 Not yet recruiting - Insulin Resistance Clinical Trials

N-acetyl-cysteine and Insulin Sensitivity in PCOS

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

The effect of N-acetylcysteine supplementation on insulin resistance and homocysteine concentrations in women with polycystic ovary syndrome will be analysed.

NCT ID: NCT03902301 Recruiting - Obesity Clinical Trials

Lactobacillus Rhamnosus and PCOS Treatment

ProjectPCOS
Start date: February 1, 2019
Phase: N/A
Study type: Interventional

The effect of Lactobacillus rhamnosus supplementation on body weight, hyperandrogenism and insulin resistance in overweight and obesity women with Polycystic Ovary Syndrome will be analysed.

NCT ID: NCT03896841 Completed - Clinical trials for Polycystic Ovary Syndrome

Ocular Findings of Polycystic Ovary Syndrome

Start date: March 17, 2013
Phase:
Study type: Observational

Purpose: This study aimed to compare the ocular surface disease test results, anterior segment parameters, and ocular response analyzer (ORA) findings of polycystic ovary syndrome (PCOS) patients with those of healthy reproductive age female controls.

NCT ID: NCT03876665 Recruiting - Clinical trials for Polycystic Ovary Syndrome

The Experience of Living With Polycystic Ovary Syndrome in the Military

PCOS
Start date: June 2019
Phase:
Study type: Observational

The purpose of this study is to understand the experience of living with polycystic ovary syndrome (PCOS) as an active duty Service Woman. As part of a budding research program, this proposed study will lay the groundwork for future intervention studies targeting the management of PCOS in a military population.

NCT ID: NCT03876145 Recruiting - Clinical trials for Polycystic Ovary Syndrome

The Four Methods of Ovarian Stimulation in Patients With Polycystic Ovarian Syndrome

Start date: November 12, 2016
Phase: N/A
Study type: Interventional

This study is a randomized controlled clinical trial to compare the pregnancy outcomes of mild and minimal stimulation in infertile women with polycystic ovarian syndrome. The study population consisted of all infertile women with polycystic ovary syndrome based on Rotterdam criteria who have not succeed to achieve fertility despite multiple treatments such as drug therapy, laparoscopic surgery, and the frequent failure of induction therapy using gonadotropins and are now candidate for in vitro fertilization (IVF) or intra cytoplasmic sperm injection (ICSI) in Reproductive Biomedicine Research Center, Royan institute, Tehran Iran.

NCT ID: NCT03871868 Completed - Clinical trials for Vitamin D Deficiency

Vitamin D Levels And Myoma Uteri

Start date: December 1, 2018
Phase:
Study type: Observational

Women with at least one uterine leiomyoma and polycystic ovary syndrome over 10 mm and women with normal ultrasonographic findings were included in the study. Blood samples were taken for biochemical analysis such as vitamin D, calcium, magnesium, phosphorus, thyroid stimulating hormone (TSH), hemoglobin (hb), hematocrit (htc), platelet (plt), and albumin. The study groups were compared in terms of these biochemical markers and family history of patients, daily sunshine hours, clothing preferences and education level.