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Abortion, Spontaneous clinical trials

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NCT ID: NCT06295939 Active, not recruiting - Grief Clinical Trials

Effect of Social Support Program on Grief of Pregnancy Loss in Sunpasitthiprasong Hospital

Start date: April 29, 2022
Phase: N/A
Study type: Interventional

Research Question: Does participation in a social support program have an impact on the Perinatal Grief Scale of women who experience pregnancy loss through abortion? Research hypothesis 1. The grief scores from pregnancy loss among women who had to terminate their pregnancies in the group receiving social support program were lower than those in the group receiving standard nursing care. 2. The grief scores from pregnancy loss among women who had to terminate their pregnancies after receiving the social support program were lower than those before receiving the social support program. Primary Objectives: To study the grief and sorrow resulting from the loss of a fetus due to pregnancy termination in women who have undergone social support programs, in comparison to those who have received regular nursing care. Secondary Objectives: 1. To investigate the grief and sorrow resulting from the loss of a fetus due to pregnancy termination after receiving social support programs compared to before receiving such programs. 2. To examine the grief and sorrow following pregnancy termination before returning home and one month after miscarriage. 3. To explore other outcomes of pregnancy termination, such as complete abortion, uterine curettage, and post-miscarriage complications.

NCT ID: NCT06048276 Active, not recruiting - Pregnancy Clinical Trials

Miscarriage Preventing Herbal Medicines and the Risk of Birth Defects: a Population-based Cohort Study

Start date: January 1, 2023
Phase:
Study type: Observational

Using data from a population-based medicine use cohort in Xiamen, China, this retrospective cohort study will investigate whether herbal medicines used to prevent miscarriage are associated with increased risk of birth defects.

NCT ID: NCT05896657 Active, not recruiting - Clinical trials for Infertility Unexplained

Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

The objective of the project is to elucidate if the oral administration of Ligilactobacillus salivarius CECT5713 is capable of improving the rates of term pregnancies in couples with infertility problems of unknown cause. On the other hand, the project is aimed to detect microbiological, immunological and hormonal markers that allow the identification of couples in which the administration of the strain could be particularly effective. This is a randomized, double-blind, parallel-group controlled nutritional intervention study. The intervention (Ligilactobacillus salivarius CECT5713 or placebo) will be performed during the 6 months prior to the fertility treatment and during the first IVF cycle (estimated 1-2 months). In case of pregnancy, the woman will continue the treatment until 12 weeks of gestation.

NCT ID: NCT05782660 Active, not recruiting - Pregnancy Related Clinical Trials

Cash Benefits and Reproductive/Perinatal Health

Start date: July 27, 2020
Phase: N/A
Study type: Interventional

During the first two years of the COVID-19 pandemic, the City of Chelsea, Massachusetts held a lottery to allocate cash benefits to its residents for ten months. Using data from the Chelsea Eats program, the investigators propose to study the impact of the cash benefit on reproductive and perinatal health.

NCT ID: NCT04621773 Active, not recruiting - Clinical trials for Recurrent Pregnancy Loss

Live Birth Rate in Patients With Unexplained Recurrent Pregnancy Loss

Start date: September 1, 2020
Phase:
Study type: Observational [Patient Registry]

STUDY AIM: to study the pregnancy outcomes and offspring development of patient with Unexplained Recurrent Pregnancy Loss Treated by PGS and spontaneous pregnancy, and to compare the health economic indicators and patient satisfaction of the two modes of pregnancy, so as to better guide the clinical treatment.

NCT ID: NCT04595760 Active, not recruiting - Pregnancy Outcomes Clinical Trials

Factors Influencing Fertility or Pregnancy Health

Start date: October 19, 2020
Phase:
Study type: Observational

Background: The North Carolina Early Pregnancy Study (EPS) was held from 1982 to 1986. Women who were trying to get pregnant took part in the study. They collected urine samples. They kept diaries. They filled out surveys. They answered questions about their partners. They were asked about their drug use. Data about air pollution and other exposures were also collected. A follow-up study was held from 2010 to 2011. Researchers want to use the data and samples to study factors that affect reproductive success. Objective: To examine behavioral and environmental exposures and reproductive health, such as menstrual cycles, conception, pregnancy loss, and pregnancy outcomes. Eligibility: The 221 healthy women age 21-42 who were planning to get pregnant and took part in the 1982-86 North Carolina EPS at the time they stopped using all birth control. A 2010-11 follow-up included 173 of these women. Design: This study uses existing data. No new data will be collected in this study. Stored urine samples may be used. Data from surveys and other sources will be used. All of the women who gave data and samples will be included. Electronic data is held in secure databases. The data is kept on computers that are password protected. Hard-copy data are stored in locked file cabinets. The study will take place at more than one site. Data will be shared with groups outside the NIH.

NCT ID: NCT04544462 Active, not recruiting - Infertility Clinical Trials

ANXA5 M2 Haplotyping in IVF Patients and Embryos

Start date: February 10, 2020
Phase:
Study type: Observational

This study aims to characterize the association between history of pregnancy complications and M2 carrier status in IVF patients and the utility of M2 haplotype preimplantation genetic testing (PGT) in embryos produced by carrier couples. Participants in this study will be screened for the M2 variant. History of pregnancy complications and miscarriages will be studied in order to determine potential associations with M2 carrier-ship.

NCT ID: NCT04360564 Active, not recruiting - Clinical trials for Pregnancy Complications

RPL: Interval to Live Birth and Adverse Perinatal Outcomes

Start date: May 13, 2020
Phase:
Study type: Observational

This will be a retrospective observational cohort study utilizing the data from the British Columbia Perinatal Data Registry (BCPDR). The BCPDR is a provincially inclusive database that aggregates obstetrics and neonatal variables from all attended births in British Columbia. The primary objective of this study is to evaluate and contrast the average time interval from the first to second birth for patients with recurrent pregnancy loss compared to healthy controls. Secondarily, the investigators will calculate the cumulative live birth rate in the cohort of women with recurrent pregnancy loss who were </= 35 at age of first birth and delivered between the years 2000-2010. Finally, the investigators will compare the incidence of adverse perinatal outcomes for those with recurrent pregnancy loss and those without. The results of this study will be valuable for clinicians and patients as it will provide information for prognosis counselling. This will also help those desiring more than one child with long term family planning.

NCT ID: NCT04156126 Active, not recruiting - Infertility Clinical Trials

Measuring Immune Tolerance to Predict Miscarriage or Failed Embryo Transfer

Start date: August 23, 2019
Phase:
Study type: Observational

Pregnancy is a unique period which requires alterations in the immune system to allow for tolerance of a haploidentical fetus. The goal of this study is to measure maternal blood levels of proteins known to promote immune tolerance in early implantation and pregnancy to look for associations between tolerance, miscarriage and failed embryo transfer. Establishing predictive factors of miscarriage and failed in vitro fertilization could have implications for a large portion of couples and serve to guide current and future family planning efforts.

NCT ID: NCT03970954 Active, not recruiting - Clinical trials for Recurrent Miscarriage

Low-dose Interleukin-2 in Women With Unexplained Miscarriages

FaCIL-2
Start date: January 5, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to demonstrate the ability of low dose IL-2 to stimulate peripheral blood Tregs of women with unexplained repeated early spontaneous miscarriages for development of a therapy to prevent fetal rejection by low dose IL-2.