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Wounds and Injuries clinical trials

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NCT ID: NCT06325228 Enrolling by invitation - Healthy Clinical Trials

Incidence of Musculoskeletal Injuries, Sports Performance, Sports Specialization, and Quality of Life in Young Athletes

Start date: February 1, 2023
Phase:
Study type: Observational

The primary aim of this observational cohort study is to assess sports specialization, sports performance, history of injuries (prevalence, types, areas, duration) and quality of life in young healthy athletes aged 8-16 from Poland. Athlete profiles will be created based on the variables (explained in detailed description) examined. Furthermore, the investigators will perform one-year injury follow-up. The main questions it aims to answer are: - Do athletes with a specific profile (lower values in athletic performance tests, low values in quality of life) evaluated at one time point, suffer injury in the future in annual observation? - Do athletes with high sports specialization will sustain injury in one-year follow-up? - Does sports specialization have a relationship with sports performance tests, and quality of life? - Does value of the specific muscle (lower limb) isometric strength will be associated with the dynamic balance scores in young healthy athletes?

NCT ID: NCT06264752 Enrolling by invitation - Acute Kidney Injury Clinical Trials

Multi-hospital Electronic Decision Support for Drug-associated Acute Kidney Injury

MEnD-AKI
Start date: February 15, 2024
Phase: N/A
Study type: Interventional

This study is a randomized controlled trial at eight hospitals within the University of Pittsburgh Medical Center-UPMC system. The project will assess the efficacy of a clinical surveillance system augmented with real-time predictive analytics to support a pharmacist-led intervention delivered to attending physicians (primary service) to reduce the progression and complications of drug-associated acute kidney injury (D-AKI) in hospitalized (non-ICU) adults.

NCT ID: NCT06190470 Enrolling by invitation - Spinal Cord Injury Clinical Trials

Effects of Marijuana on Neuropathic Pain and Spasticity in Spinal Cord Injury Patients

Start date: January 2, 2024
Phase: Phase 1
Study type: Interventional

The goal of this clinical trial is to compare effects of marijuana or cannabis on neuropathic pain and spasticity in spinal cord injury patients. The main question is: Does the cannabis product from KhonKaen University reduce neuropathic pain and spasticity in spinal cord injury patients? The research design is a crossover study. The participants will be randomly into 2 groups: group 1 and group 2. The participants received either cannabis or placebo for 2 weeks. After completing treatment, participants were swapped to the other group for 2 weeks, a wash-out period is 2 weeks. The outcome measurements are pain and spasticity.

NCT ID: NCT06103409 Enrolling by invitation - Burn Wound Clinical Trials

MSCs for the Treatment of Burn Wounds

Start date: June 30, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this study is to evaluate the capacity of allogenic mesenchymal stromal cells form bone marrow (BM-MSC) or adipose tissue(Ad-MSC) to induce wound healing in patients with burn wounds.

NCT ID: NCT06030531 Enrolling by invitation - Clinical trials for Spinal Cord Injuries

Spasticity and Functional Recovery After SCI

Start date: July 1, 2020
Phase:
Study type: Observational

Spasticity is one of the most common symptoms manifested in humans with spinal cord injury (SCI). However, the neural mechanisms underlying the development of spasticity over time after an acute SCI are not yet understood. Using electrophysiological and imaging techniques along with traditional measurements of neurological recovery in the acute rehabilitation setting including physical exam and functional assessments; the investigators aim to examine the relationship between development of spasticity, residual descending motor pathways and functional and neurological recovery in humans with SCI from acute to subacute phase

NCT ID: NCT06007599 Enrolling by invitation - Clinical trials for Total Knee Replacement

Wound Healing in Primary TKA

Start date: August 16, 2023
Phase: N/A
Study type: Interventional

Wound complications after total knee arthroplasty (TKA) can arise from many patient-specific factors, such as vascular or immune-related medical conditions, obesity, and smoking, among others. The development of early wound complications can lead to increased length of hospital stay and more serious complications, including deep infection and major subsequent surgery. However, there are modifiable variables that could affect the risk of getting wound complications, such as the closure technique. This study aims to analyze the difference in rates of wound complications using two different closure techniques in primary TKA.

NCT ID: NCT05989906 Enrolling by invitation - Clinical trials for Spinal Cord Injuries

Feasibility of a Sprint Interval Training Program During Inpatient Spinal Cord Injury Rehabilitation

SIT
Start date: August 23, 2023
Phase: N/A
Study type: Interventional

This study will assess the feasibility and efficacy of 3 treatments to increase physical activity during and after inpatient rehabilitation (IPR) for new spinal cord injuries: 1. Program of sprint interval training (SIT) on an arm crank ergometer during IPR 2. SIT + Provision of an arm ergometer (ERGO) for home use 3. SIT + ERGO for home use + Motivational interviewing to increase adherence to exercise during and after IPR. The primary outcome is minutes per week of moderate to vigorous physical activity at 6 months after IPR discharge. Secondary outcomes include peak power on the 6-Minute Arm Test at IPR discharge and self-reported physical activity, depression, fatigue, pain, community participation, and quality of life at 6 months after IPR discharge. The investigators will obtain data on feasibility, acceptability, and perceived benefits of the treatments from stakeholders. The results of this pilot study will inform the design of a larger randomized trial.

NCT ID: NCT05942638 Enrolling by invitation - Clinical trials for Brain Injuries, Traumatic

Longitudinal Assessment of Post-concussion Driving in Young Adults

LAPDYA
Start date: August 29, 2023
Phase:
Study type: Observational [Patient Registry]

Upwards of 3.8 million concussions occur annually in the United States. Driving is a highly complicated activity that requires visual, motor, and cognitive skills, which are commonly impaired after concussion. Yet, the time course of post-concussion driving impairment has not been characterized. There is a critical need to 1) determine when concussed individuals should return to driving and 2) identify the key concussion assessment predictors of readiness to return to driving. In the absence of formal recommendations, impaired concussed drivers are at risk to themselves and others on the road. The first specific aim is to compare simulated driving between concussed individuals and non-concussed yoked matched controls across five longitudinal timepoints (pre-injury baseline, day 2, day 4, asymptomatic, and unrestricted medical clearance) and daily naturalistic driving from day 2 to day 9. Driving recommendations must be appropriate and necessitated by concussion impairments, since excessively strict recommendations wrongfully strip concussed patients of their independence and may dissuade individuals from seeking medical care. The second specific aim is to identify widely used concussion assessment outcomes that predict simulated driving performance among concussed individuals throughout concussion recovery. To address these aims, 100 concussed and 100 yoked matched control young adult college athletes will complete a simulated driving assessment and a robust concussion assessment battery at pre-injury baseline, day 2, day 4, asymptomatic, and unrestricted medical clearance. Naturalistic driving (measured with in-car global positioning systems) will be captured from day 2 to day 9 (7 days total). This study will determine the acute and subacute time course of post-concussion driving impairment and determine key predictors of post-concussion driving performance. Results from this innovative approach will have a broad and positive impact that will improve the safety of both concussed individuals and the general population, guide the practices of health professionals, inform the future work of researchers, and substantiate the work of policy-makers by providing evidence-based recommendations for managing post-concussion driving.

NCT ID: NCT05942235 Enrolling by invitation - Clinical trials for Educational Problems

The Use of Microlearning in Nursing Education

Start date: October 6, 2022
Phase:
Study type: Observational

The goal of this randomized controlled study is to evaluation the effect of mobile application-based wound healing course on clinical reasoning skills in nursing student. The main questions it aims to answer are: - Does microlearning-based courses have an effect on clinical reasoning skills of nursing students compared to traditional courses? - Does microlearning-based courses have an effect on the retention of knowledge in nursing students compared to traditional courses? Participants will consist of students enrolled in the Surgical Diseases Nursing course in the fall and springs semester of the 2022-2023 academic year in the Department of Nursing at the Faculty of Health Sciences of Karadeniz Technical University. If there is a comparison group: Researchers will compare experimental group to see if control group.

NCT ID: NCT05929833 Enrolling by invitation - Clinical trials for Traumatic Brain Injury

BETTER (Brain Injury Education, Training, and Therapy to Enhance Recovery)

Start date: January 26, 2024
Phase: N/A
Study type: Interventional

Despite racial/ethnic disparities in outcomes for younger adults with traumatic brain injury (TBI), there are no U.S. standards for TBI transitional care for patients discharged home from acute hospital care. To enhance the standard of care, the investigators will examine the efficacy of the existing intervention named BETTER (Brain Injury, Education, Training, and Therapy to Enhance Recovery), a culturally-tailored, patient- and family-centered TBI transitional care intervention, compared to usual care, among younger adults with TBI and families. The knowledge generated will drive improvements in health equity for younger adults with TBI of various races/ethnicities and families, resulting in improved health of the public.