Type 2 Diabetes Clinical Trial
Official title:
Effect of Moderate Alcohol Consumption on PPAR-γ Activity and Risk Markers of Metabolic Disease: Influence of Genetic Variation in Alcohol Oxidation
Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease
and type 2 diabetes. The association of alcohol consumption with cardiovascular disease is
mediated by a functional polymorphism of alcohol dehydrogenase 1c, but the effect of this
polymorphism on alcohol metabolism is only investigated in vitro.
The risk reduction of moderate alcohol consumption for cardiovascular disease is explained
largely by an increase of HDL cholesterol, but an increase of adiponectin concentrations
after moderate alcohol consumption may also be involved. It seems likely that adiponectin is
a mediator for the association of moderate alcohol consumption with type 2 diabetes. The
mechanism by which moderate alcohol consumption increases adiponectin concentrations is
unknown, but ppar-gamma activation may be involved.
effects of this polymorphism on mediators of this relation are not known. This study
therefore investigates the effect of moderate alcohol consumption and the influence of
alcohol dehydrogenase 1c polymorphism on ppar-gamma activated gene expression and risk
factors of cardiovascular disease and type 2 diabetes.
Status | Completed |
Enrollment | 36 |
Est. completion date | June 2006 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 40 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Healthy women aged 40 to 65 years - Absence of menstrual period for at least 2 years - Homozygotes for the ADH1C*1 or ADH1C*2 allele of ADH1C I349V polymorphism - Alcohol consumption = 5 and = 21 units/week Exclusion Criteria: - Smoking - Family history of alcoholism - History of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disorders and gastrointestinal disorders - Recent blood donation |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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TNO |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | PPAR-gamma activated gene expression | |||
Secondary | Risk factors of cardiovascular disease and type 2 diabetes | |||
Secondary | Postprandial changes of HPA-axis activity |
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