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Syndrome clinical trials

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NCT ID: NCT06090981 Recruiting - Clinical trials for Meconium Aspiration Syndrome

Early Bolus Surfactant Replacement Therapy Versus Standard Care in Term Neonates With Meconium Aspiration Syndrome

Start date: March 12, 2022
Phase: N/A
Study type: Interventional

The objective of the study is to compare the total duration of respiratory support in term neonates (≥37weeks) with meconium aspiration syndrome, who are provided early(≤2hr) bolus surfactant therapy versus standard care.

NCT ID: NCT06090110 Recruiting - Clinical trials for Irritable Bowel Syndrome

Vagal Nerve Stimulation in Irritable Bowel Syndrome

RESILIENCE
Start date: December 1, 2023
Phase: N/A
Study type: Interventional

This randomized control trial aims to evaluate the effect of transcutaneous auricular vagal nerve stimulation in patients with irritable bowel syndrome. The intervention will be 8 weeks of treatment with a vagal nerve stimulator. The main objectives are: - To evaluate the clinical response, defined as a decrease of at least 50 points on the IBS-SSS questionnaire, of the treatment. - To ascertain whether the autonomic-vagal neurosignature, derived from pre-treatment registration of symptom profiles, autonomic responses and imaging of neuronal activity as a reaction to stress is able to predict therapeutic response to tVNS accurately. - To evaluate the effect of treatment on quality of life - To evaluate the effect of treatment on depression - To evaluate the effect of treatment on anxiety Participants will be asked to wear a wearable (Fitbit) and fill out a daily questionnaire for one week. Thereafter, a functional brain MRI will be performed. In the intervention group patients will receive transcutaneous nerve stimulation for 8-weeks at home. The comparison group will receive the same device but with a non-conducting electrode. Patients fill out weekly questionnaires during the treatment period and at follow-up moments 3 and 6 months after finishing the treatment period.

NCT ID: NCT06087757 Recruiting - Williams Syndrome Clinical Trials

Clemastine Treatment in Individuals With Williams Syndrome

Start date: April 1, 2024
Phase: Phase 3
Study type: Interventional

This study explores the neurobiological etiology of Williams syndrome and potential therapeutic targets for associated social, motor, and cognitive abnormalities. The main translational objective will be to test the effectiveness of Clemasntine on neurocognitive and other associated abnormalities in individuals with Williams syndrome.

NCT ID: NCT06081088 Recruiting - Pain Clinical Trials

Graded Motor Imagery Training in Shoulder Impingement Syndrome

Start date: October 16, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effects of Graded Motor Imagery (GMI) training on pain, functionality, disability and daily living activities in patients diagnosed with Shoulder Impingement Syndrome.

NCT ID: NCT06079944 Recruiting - Clinical trials for Shoulder Impingement Syndrome

Effects of Progressive Resistance Training Combined With Traditional Physical Therapy in Patients With Shoulder Impingement Syndrome

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

A randomized control trial will be done on diagnosed Shoulder impingemnet patients with physical therapy screening in Fauji Foundation Hospital Rawalpindi. There is a growing demand on finding treatments which can be more beneficial and can be started early on in the treatment phase, nowadays. The purpose of the study is to determine the "effects of progressive resistance training combined with traditional physical therapy in patients with shoulder impingement syndrome" using the resistance band and multipulley system. The traditional physical therapy will include hot pack placed on shoulder and neck region for ten minutes, Transcutaneous electrical nerve stimular will be used and the electrodes will be placed on the desired area (shoulder complex) the intensity will be increased manually according to the capacity of the patient and the treatment time will be of 15 minutes, stretching exercises such as doorway stretch and foam roll supine stretch will be done in the hospital for first 3 weeks and the next 3 weeks will be for home exercises moving from 5 repetitions to 20 repetitions for a set of 3. stretch will be hold for 30 seconds

NCT ID: NCT06079788 Recruiting - Clinical trials for Nephrotic Syndrome in Children

Study of Adrenocorticotropic Hormone on Children With Frequent Relapse or Steroid-dependent Nephrotic Syndrome: a Prospective, Multicenter, Randomized,Open-label Clinical Trial.

Start date: November 1, 2023
Phase: Phase 3
Study type: Interventional

Primary nephrotic syndrome accounts for approximately 90% of the total number of nephrotic syndrome in childhood and it is the most common glomerular disease in children. Although treatment with steroids is useful for primary nephrotic syndrome, proving to cause frequent relapse/steroid-dependent nephrotic syndrome after treatment and the usage of immunosuppressive agents has become a new choice for the treatment of such patients. This study is a prospective, multicenter, randomized,open-label clinical trial, evaluating the efficacy and safety of steroid combined with adrenocorticotrophic hormone(ACTH) to children who with frequently relapsing or steroid-dependent nephrotic syndrome, all we wish to obtain the proper drug choice and individualized treatment options for children with nephrotic syndrome.

NCT ID: NCT06078553 Recruiting - Clinical trials for Congenital Myasthenic Syndrome

A Natural History Study in Participants With DOK7 Congenital Myasthenic Syndromes (CMS)

Start date: February 13, 2024
Phase:
Study type: Observational

Participants will attend up to 3 study visits to collect clinical assessments. The assessments will evaluate participants' symptoms and quality of life to understand disease activity in patients with DOK7-CMS better and may inform future study design.

NCT ID: NCT06077175 Recruiting - Anxiety Clinical Trials

HAND MASSAGE AFTER ACUTE CORONARY SYNDROME

Start date: October 30, 2023
Phase: N/A
Study type: Interventional

Patients suffering from Acute coronary syndrome may be hospitalized again in a shorter time than expected, and after being discharged, they may live within the limitations imposed by the disease until the end of their lives. This situation causes anxiety in individuals. Today, various methods are used to reduce high levels of anxiety. Massage is the planned and purposeful application of touch and is the most common, most important and oldest complementary treatment used in traditional practices. It is also thought that the comfort levels of individuals experiencing ACS will increase by reducing their anxiety. This study was planned to determine the effect of hand massage applied to patients with ACS on comfort, anxiety level and vital signs.

NCT ID: NCT06076876 Recruiting - COVID-19 Clinical Trials

Prevalence and Risk Factors of Anxiety and Depression Among Policemen During the Health Crisis Linked to COVID-19

Covid19-Police
Start date: June 20, 2023
Phase:
Study type: Observational

To date, there is little international data on depression and anxiety among police officers apart from studies carried out after an attack or natural disaster. At the national level, no mental health data exists for police officers, apart from those from the Paris attacks, and the work of investigators after the Strasbourg attack (article in press). During the covid crisis, in Alsace, the police, like the rest of the population, took the full brunt of the pandemic. The police, however, are part of essential professions and have not been confined, but on the contrary, have remained in contact with the population, in particular to carry out traffic controls. Studies published to date show varying mental health outcomes for essential occupations during the pandemic. The investigators hypothesize that the police officers had a feeling of being more exposed and that their mental health could be affected. For this it was decided to compare two populations of departments of similar size, but with different exposure to the pandemic: Bas Rhin and Hérault French departments

NCT ID: NCT06076499 Recruiting - Clinical trials for Restless Legs Syndrome

A Post-Market Study for Long-Term Effectiveness and Safety of the NTX100 for RLS

THRIVE
Start date: November 15, 2023
Phase:
Study type: Observational

Multi-center post-market, observational study to assess the long-term effectiveness and safety of the NTX100 TOMAC System for patients with Restless Legs Syndrome.