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Syndrome clinical trials

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NCT ID: NCT05051917 Recruiting - Clinical trials for Patients With Acute Coronary Syndrome and Angiographic Evidence if Coronary Aneurysms and/or Ectasia

The Italian Coronary Artery Aneurysm and Ectasia Observational Study In Patients With Acute Coronary Syndrome

Start date: September 1, 2021
Study type: Observational

The ITACA study is a prospective, observational no profit registry enrolling patients with Acute Coronary Syndrome and angiographic evidence if coronary aneurysms and/or ectasia.

NCT ID: NCT05051514 Recruiting - Clinical trials for Obstructive Sleep Apnea Syndrome

Muscle Tone Change in OSA

Start date: April 18, 2021
Study type: Observational

To investigate the differences in respiratory functions, orofacial muscle tone changes, anxiety/depression, and quality of life of the patients according to the severity of Obstructive Sleep Apnea Syndrome.

NCT ID: NCT05050877 Completed - Clinical trials for Coronary Artery Disease

Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention II

Start date: June 1, 2000
Study type: Observational

As a multi-center, retrospective observation study in southern China, this study included the main study population of patients who underwent coronary angiography at 5 hospitals from Guangzhou, Shenzhen, Yangjiang, Maoming and Longyan from January 2000 to Decemeber 2020. The hospitalization information was collected in the form of direct derivation of the case, and cardiac and renal adverse events were collected through outpatient system. Data on all-cause death were obtained from the Guangdong Provincial Public Security and matched to the electronic Clinical Management System of the Guangdong Provincial People's Hospital records.

NCT ID: NCT05049928 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea Syndrome

m-Rehab OSA : Impact of a Telerehabilitation Program Associated With CPAP on Severity Markers of Obstructive Sleep Apnea Syndrome

Start date: September 2021
Phase: N/A
Study type: Interventional

Obstructive sleep apnea syndrome (OSA) is a common condition associated with major repercussions such as excessive daytime sleepiness and impaired quality of life as well as metabolic and cardiovascular complications. Continuous positive airway pressure (CPAP) remains the treatment of choice but its effectiveness remains limited, especially in reducing cardio-metabolic risk. Interventions to modify the lifestyle are therefore recommended in the management of OSA. The emergence of information and communication technologies is an opportunity for patients to have tools that promote self-management and behavioral changes. The recent development of telerehabilitation (TR) is a promising approach that has only been the subject of pilot studies. In a randomized, controlled and multicenter study, we propose to test the hypothesis according to which the use of a mobile TR solution, associated with continuous positive airway pressure (CPAP), will allow obese patients to adopt behavioral modifications to improve markers of severity of OSA. The analysis of big data (data-mining) will allow a better understanding of the motivational obstacles and levers.

NCT ID: NCT05049304 Completed - Metabolic Syndrome Clinical Trials

Prevention With Oleanolic Acid of Insulin Resistance

Start date: January 1, 2020
Phase: N/A
Study type: Interventional

Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as component of functional foods in the prevention of metabolic syndrome due to its anti-inflammatory activity. In this research project we will study the presence of OA in postprandial TRL in healthy adolescents and in normal weight. Moreover, THP-1 macrophages will be incubated with LPS for 48h after pretreatment with OA at different concentrations. Also, TRL will be isolated from healthy adolescents before and 2 and 5h postprandially after the intake of a meal containing the functional olive oil or common olive oil and incubated with THP-1 macrophages.

NCT ID: NCT05048602 Recruiting - Arrhythmia Clinical Trials

Drug-induced Brugada Syndrome Research Database

Start date: September 7, 2021
Study type: Observational

All patients with drug-induced Brugada syndrome who are evaluated and followed at each participating centers will be recorded in this register. Within this register a characterization of patients and therapy will be done. Prognostic factors of adefined clinical relevant endpoints will be evaluated.

NCT ID: NCT05047952 Not yet recruiting - Fatigue Clinical Trials

Vortioxetine for Post-Covid-19 Syndrome

Start date: September 2021
Phase: Phase 2
Study type: Interventional

A randomized, double-blinded, placebo-controlled trial will be conducted to evaluate vortioxetine, an antidepressant with established pro-cognitive properties, for the treatment of cognitive deficits which develop during or after an infection consistent with COVID-19, continue for more than 12 weeks and are not explained by an alternative diagnosis (i.e., post-COVID-19 syndrome). Participants will receive vortioxetine (10-20 mg) or placebo for 8 weeks. Changes in cognitive functioning from baseline to endpoint (week 8) will be assessed via the Digit Symbol Substitution Test (DSST).

NCT ID: NCT05047705 Not yet recruiting - Tourette Syndrome Clinical Trials

Investigating Distress Tolerance in Adults With Tourette Syndrome

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Although behavior therapy is recognized as a first-line intervention for Tourette's Disorder (TD), less than 40% of adults with TD respond to this evidence-based treatment. Limited tolerance for aversive premonitory urges and affective states that accompany tics may be one likely factor that impedes behavior therapy outcomes. This study examines the relationship between distress tolerance and tic inhibition among adults with TD, and investigates the mechanism and effect of therapeutic skills training to enhance distress tolerance abilities. Findings will determine the optimal approach to enhance distress tolerance among adults with TD and ultimately lead to better behavior therapy outcomes.

NCT ID: NCT05047367 Completed - Anxiety Clinical Trials

The Relationship of Psychological Factors and Sleep Quality With the Severity of Carpal Tunnel Syndrome

Start date: January 13, 2021
Study type: Observational [Patient Registry]

The most common entrapment neuropathy symptoms, the diagnosis of CTS, is determined by examination findings and by means of the results of electro-diagnostic test. With an increase in disease severity, trap neuropathy, whose symptoms are more pronounced at night, negatively affects the daily life of the person. Deterioration in sleep quality may cause depression and anxiety. Conflicting results have been found in the studies related to these findings. However, no study was found in which daytime sleepiness was evaluated in terms of CTS. The invsetigators aim in this study is to evaluate the relationship between CTS severity and depression, anxiety, sleep quality and daytime sleepiness.

NCT ID: NCT05047354 Not yet recruiting - CHILD Syndrome Clinical Trials

Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism

Start date: September 24, 2021
Study type: Observational

Background: Smith-Lemli-Opitz Syndrome (SLOS) is a genetic disorder. It can cause birth defects and developmental delays. There is no cure for SLOS or other inherited diseases related to cholesterol production or storage. The data gained in this study may help researchers find ways to measure how well future treatments work. Objective: To learn more about SLOS and related disorders and how these diseases affect participants and relatives. Eligibility: People of any age who have or are suspected to have SLOS or another inherited disease related to cholesterol production or storage. Relatives are also needed. Design: Participants will be screened with a medical record review. Participants will have visits every 6 to 12 months. They will have a physical exam. They will fill out a survey about their medical and behavioral history. They may have an eye exam. They may have a neurodevelopmental assessment. They may have a hearing test. Their outer and middle ears may be examined. Their ability to speak, understand speech, eat, and swallow may be assessed. They may get X-rays while they chew and swallow. Their functional ability and needs for adaptive devices or braces may be assessed. They may have a lumbar puncture. Photographs may be taken of their face and body. Participants who cannot visit the NIH and relatives will have a virtual visit once a year. They will talk about their medical history and symptoms. They give blood, urine, and skin samples at a lab near their home. They will fill out a survey about their medical and behavioral history. Participation will last for several years.