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Saliva clinical trials

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NCT ID: NCT06437262 Completed - Healthy Clinical Trials

Antibacterial Effect and Substantivity of a New Chlorhexidine and Cymenol Gel on Oral Biofilm and Saliva

Start date: September 1, 2022
Phase: Phase 1
Study type: Interventional

The objective of this project was to compare the immediate antimicrobial effect and in situ substantivity of a new 0.20% chlorhexidine (CHX) gel and cymenol with the current CHX gel formulation on dental plaque biofilm and salivary flora up to 7 hours after a single application.

NCT ID: NCT05793099 Completed - Child Clinical Trials

Effect of 5% Aqueous Propolis in Salivary and Dental Plaque pH in Children

Start date: December 16, 2022
Phase: N/A
Study type: Interventional

This study aims to investigate the changes in saliva and dental plaque pH after consuming sugar-free chewing gum containing 5% of aqueous propolis in children aged between 8-11 years. The studied sample will be divided into two groups: Group A (Control group) placebo chewing gum, and Group B (Experimental group) aqueous propolis chewing gum. All children will experience both types of chewing gum with an interval of 1 week between the two studied groups.

NCT ID: NCT05635929 Completed - Pain Clinical Trials

Oral Mucositis and Quality of Life With a Mucosa Topical Composition in Head & Neck Cancer Patients.

Start date: October 11, 2022
Phase: N/A
Study type: Interventional

PROMs questionnaires seem to be an effective tool to obtain a greater knowledge of the physical and emotional state of patients. Despite this, few studies have been performed using patient reported outcomes in Head & Neck (H&N) cancer patients during and after treatment. The use of a novel topical mucosa composition (Saliactive®) is studied along the use of questionnaires.

NCT ID: NCT05437874 Completed - Dental Plaque Clinical Trials

Carbonated Beverage Consumption in pH and Bacterial Proliferation

pHSB
Start date: January 18, 2018
Phase: Phase 1
Study type: Interventional

The objective of this research is to evaluate the oral modifications caused by different types of coke drinks (regular coke and diet coke). The salivary and the dental biofilm pH will be determined in the first minutes after their consumption. Additionally, the bacterial proliferation of dental biofilm will be evaluated.

NCT ID: NCT05325983 Completed - Heart Failure Clinical Trials

Using Saliva Stimulation to Immediately Improve Heart Failure Inpatient's Thirst Sensation

Start date: June 24, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to Using saliva stimulation to immediately improve heart failure inpatient's thirst sensation.

NCT ID: NCT04721457 Completed - COVID-19 Clinical Trials

The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load

Start date: January 3, 2021
Phase: Phase 4
Study type: Interventional

Preoperative antiseptic mouth rinses have been widely used as a standard protocol before routine dental treatment reduces oral microorganism counts. During dental procedures, aerosolized microorganisms contaminate the dental environment and nearby surfaces and remain suspended for 4 hours. Thus, the reduction in the number of aerosolized microorganisms by pre-procedural rinsing may reduce cross-contamination between dentists, office personnel, and patients. Recent reviews have advocated the use of preoperative rinsing to control and reduce the risk of SARS-CoV-2 transmission. However, no clinical studies have been done yet to support the effectiveness of any pre-procedural oral rinses against SARS-CoV-2. The proposed study will mitigate the spread of COVID-19 disease in dental healthcare facilities and ensure the patients' good health and healthcare workers. The purpose of this clinical trial is to compare the efficacy of four commercially available mouth rinses povidone-iodine (PVP-I), hydrogen peroxide (H2O2), cetylpyridinium chloride (CPC), sodium hypochlorite (NaOCl) on the salivary SARS-CoV-2 viral load at four-time points (baseline and 5-, 30-, and 60-min post rinsing) relative to two control groups (distilled water and no-rinse) in a cohort of positive COVID-19 patients.

NCT ID: NCT04670341 Completed - Saliva Clinical Trials

The Effect of Chewing the Tapioca Pearls in Bubble Tea Drinks

Start date: September 17, 2020
Phase: N/A
Study type: Interventional

Bubble tea drinks contain tea and tapioca pearls. Chewing tapioca pearls in bubble tea drinks may increase salivary components. Because of its proteins, inorganic components, and enzymes, saliva plays an important role in the body's defense against bacteria and viruses. This study aims to analyze the effect of chewing the tapioca pearls in bubble tea drinks on salivary C-reactive protein (CRP) and calcium (Ca) levels.

NCT ID: NCT04352959 Completed - COVID19 Clinical Trials

COVID-19: Nasal and Salivary Detection of the SARS-CoV-2 Virus After Antiviral Mouthrinses

BBCovid
Start date: April 27, 2020
Phase: N/A
Study type: Interventional

Given the current lack of effective COVID-19 treatment, it is necessary to explore alternative methods to contain the spread of the infection, focusing in particular on its mode of transmission. The modes of person-to-person transmission of SARS-CoV-2 are direct transmission, such as sneezing, coughing, transmission through inhalation of small droplets, and transmission through contact, such as contact with nasal, oral and eye mucous membranes. SARS-CoV-2 can also be transmitted directly or indirectly through saliva. The use of antiviral mouthrinses may be used as adjunctive therapy.

NCT ID: NCT03612414 Completed - Quality of Life Clinical Trials

Efficacy of a Dietary Supplement (Aqualief®) in Xerostomic Patients

Aqualief
Start date: June 15, 2016
Phase: N/A
Study type: Interventional

Xerostomia is defined as the subjective complaint of dry mouth. Symptoms of dry mouth may range from mild oral discomfort to significant oral disease that can compromise patients' health, dietary intake and quality of life. Xerostomia is accompanied by numerous signs and symptoms mainly in the mucous membranes, lips, tongue, salivary glands and teeth. This study was designed to verify efficacy and safety of a novel dietary supplement (Aqualief),designed with the aim of stabilizing the saliva flux and pH at a neutral level and to improve the acid buffering capacity of saliva.

NCT ID: NCT02554604 Completed - Preeclampsia Clinical Trials

Identifying HDL Composition and Function in Preeclamptic and Normal Pregnancies

Start date: September 2015
Phase:
Study type: Observational

The study is design to assess if there is a correlation between diagnosis of preeclampsia and its severity to changes in HDL quality, in terms of composition and function and to determine whether preeclampsia-induced changes in VOCs in saliva can be used for the early diagnosis of preeclampsia.