Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia

Prostate Cancer Clinical Trial

Official title: A Prospective, Randomized Pilot Study of Enbrel VS Placebo in Patients Receiving Radiation Therapy to Combat Fatigue and Cachexia

Status Terminated

Clinical Trial Summary

Patients who receive radiation therapy often have fatigue or a decrease in feeling well causing a "wasting" away. For patients with advanced disease of lung cancer, prostate cancer, or cancer that has spread to the bone, it is hoped that this drug may decrease this. If patients feel better during treatments they can complete the therapy without any breaks in treatment. For treatment to be most effective, it should be given in the amount needed, on a particular schedule.

Clinical Trial Description

Subjects will be placed in a group to receive either the drug enbrel, or a placebo. The radiation therapy treatments are as they would be given if the person was not on a research study. The selection of the group a patient is in is done by random, like flipping a coin. The doctor is not able to influence which group anyone is selected for. As is done routinely, radiation therapy is given Monday through Friday for about 4 to 6 weeks.The injections of enbrel or placebo are given two times a week. The enbrel or placebo is given as an injection directly under the skin with a small needle. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Bone Cancer
• Lung Cancer
• Neoplasm Metastasis
• Prostate Cancer
• Prostatic Neoplasms
• Stress Disorders, Post-Traumatic

• NCT number: NCT00127387
• Study type: Interventional
• Source: The University of Texas Health Science Center at San Antonio
• Status: Terminated
• Phase: Phase 2/Phase 3
• Start date: May 2001
• Completion date: November 2005