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Clinical Trial Summary

This Phase I trial combines ADI-PEG 20 with docetaxel in patients with advanced solid tumors with emphasis on castration resistant prostate cancer (CRPC). The investigators hypothesize that the combination will result in greater tumor cytotoxicity with an acceptable toxicity profile (i.e., manageable side effects) in cancer patients due to the unique mechanism of action of ADI-PEG 20. The investigators also hypothesize that the combination of ADI-PEG 20 and docetaxel will result in enhanced tumor cell apoptosis in part due to autophagy and that this will be particularly relevant in CRPC.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01497925
Study type Interventional
Source Polaris Group
Contact
Status Completed
Phase Phase 1
Start date September 6, 2011
Completion date August 31, 2018

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