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Lung Cancer clinical trials

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NCT ID: NCT04976296 Not yet recruiting - Lung Cancer Clinical Trials

MRD Monitoring in Lung Cancer After Resection

Start date: September 1, 2021
Phase:
Study type: Observational

The conception of molecular residual disease (MRD) extending from hematologic tumor to solid tumors. Evidences supporting MRD evaluation for lung cancer by liquid biopsy has gradually accumulated, especially circulating tumor DNA (ctDNA). In this observational study, we prospectively enroll stage I-IIIA non-small cell lung cancer (NSCLC) patients who underwent complete resection. Preoperative blood sample, tumor tissue and dynamic postoperative blood samples are collected continuously for MRD detection. This study aim to explore the prognostic value of MRD for stage I-IIIA NSCLC patients after complete resection.

NCT ID: NCT04968548 Not yet recruiting - Lung Cancer Clinical Trials

Determination and Validation of a Multi-analyte Assay for Lung Cancer Screening

Start date: July 2021
Phase:
Study type: Observational

This study is part of the development and validation of a non-invasive lung screening test which aim to identify early stage lung cancer in patients at high risk for lung cancer.

NCT ID: NCT04965129 Not yet recruiting - Lung Cancer Clinical Trials

Supplementation of n-3 PUFA in the Modulation of Lean Mass in Patients With Lung Cancer Receiving a High-protein Diet

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

This study is conducted to test the hypothesis that patients with lung cancer undergoing immunotherapy receiving a high protein diet and supplemented with fish oil will improve muscle mass, therapeutic response and modulate the intestinal microbiota within a 4 month period.

NCT ID: NCT04964960 Not yet recruiting - Cancer Clinical Trials

Pembro+Chemo in Brain Mets

Start date: July 2021
Phase: Phase 2
Study type: Interventional

The goal of this study is to evaluate whether providing Pembrolizumab prolongs survival and preserves quality of life while minimizing side effects for patients with NSCLC with untreated asymptomatic brain metastasis.

NCT ID: NCT04962191 Recruiting - Lung Cancer Clinical Trials

Idylla EGFR Lung Trial

Start date: August 2021
Phase:
Study type: Observational

This retrospective, observational study will compare the results of a BioCartis' EGFR mutation test on the Idylla platform with test results from SoC pathology results from tissue biopsies in the same setting. A comparable rapid testing platform for EGFR may serve as a more accessible means to diagnose, and overall, more patients treated successfully with targeted therapies. Up to 150 samples will be tested and compared with existing results.

NCT ID: NCT04960735 Active, not recruiting - Breast Cancer Clinical Trials

Implementation, Effectiveness and Impact of a Value Based Intervention for Patients With Breast or Lung Cancer

VOICE
Start date: January 1, 2019
Phase: N/A
Study type: Interventional

VOICE project aims to guide health services in their reorganization towards the provision of the highest value care for the patient at the best cost. VOICE is targeted to patients with breast and lung cancer. The purpose is to offer a new innovative strategic framework based on value-based healthcare model to these patients in Europe. VOICE Community consists of 13 hospitals across Europe working collaboratively to implement this approach. The Community addresses what matters most to patients by measuring patient reported health outcomes in routine clinical practice on a systematic and long-term basis, by including patients´ perspective in clinical decision-making, improving patient empowerment and physician-patient communication, assessing the impact on costs of the processes implemented, identifying factors for a successful implementation of value-based healthcare and boosting knowledge generation and best practice exchange across Europe. The VOICE ambition is to collect the health-related Quality of Life evidence from more than 1000 patients (patients with breast cancer and patients with lung cancer), by means of health related and patient reported questionnaires (ICHOM, International Consortium for Health Outcome Measurements, standard sets). Hospitals will go further by assessing the satisfaction, acceptability, relationship with professionals or decision-making process with patients. The VOICE Community will benchmark health outcomes and related costs to improve care delivery of these patients.

NCT ID: NCT04957433 Recruiting - Cancer Clinical Trials

'Lung Health Check' Biomarker Study

Start date: September 28, 2020
Phase:
Study type: Observational

CT screening of lung cancer offers an opportunity to diagnose early stage lung cancers which is associated with better prognosis - indeterminate results delay diagnosis whilst interval imaging is awaited to assess risk of cancer. This study will allow us to examine the potential of blood-based biomarkers to augment CT screening for lung cancer. Hypotheses 1. Blood and sputum samples can be collected in patients attending lung health checks as part of the Lung Health Check pilot in West London at fixed and mobile scanners and safely transported for processing and storage in preparation for biomarker development. 2. The biomarkers will help to identify cohorts of 1. High-risk patients in whom CT surveillance should be conducted more readily/frequently and diagnostic procedures performed earlier. 2. Low-risk patients who might need reduced surveillance intensity. 3. Patients with interstitial lung abnormalities that share similar biomarker characteristics to patients with clinically significant interstitial lung disease

NCT ID: NCT04957030 Completed - Lung Cancer Clinical Trials

Ultralow-dose CT for Lung Cancer Screening

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

Therefore, the purpose of this study was to investigate whether ULDCT with ASiR-V can be used for the detection and diameter measurement of pulmonary nodules at an extremely low dose comparable to those associated with plain-film chest radiography. Furthermore, mixed-effects logistic regression analysis was used to determine independent predictors for the sensitivity of pulmonary nodule detection to explore the application range of ULDCT in Chinese patients.

NCT ID: NCT04954625 Recruiting - Lung Cancer Clinical Trials

Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

A postoperative autologous blood patch (ABP) intervention trial for patients who underwent lung resection for cancer to examine its effectiveness in preventing a prolonged air leak. AIM 1: To determine the safety and efficacy of autologous blood patch (ABP) as a means to reduce the rate of prolonged air leak (PAL) after lung cancer resection AIM 2: To prospectively examine variation in morbidity and quality of life between patients with and without a PAL

NCT ID: NCT04952272 Recruiting - Lung Cancer Clinical Trials

Intratumor CpG-ODN Boosters Immune Killing Against in Situ Tumor Antigen Release for Advanced Solid Tumors

Start date: March 1, 2021
Phase: Phase 1
Study type: Interventional

To study the safety and clinical effects of intratumor injecting CpG-ODN and in situ release of tumor antigen by interventional ablation or drug-eluting beads to treat advanced solid tumors.