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Prediabetic State clinical trials

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NCT ID: NCT05090202 Not yet recruiting - Clinical trials for Chronic Heart Failure

Prediabetes and Newly Diagnosed Diabetes in Chronic Heart Failure

Start date: December 30, 2022
Phase:
Study type: Observational [Patient Registry]

The aim the study is to determine the prevalence of prediabetic dysglycemia and newly diagnosed diabetes among individuals with CHF(chronic heart failure) in sohag university hospital patients .

NCT ID: NCT05073237 Withdrawn - Obesity Clinical Trials

Effects of Novel Estrogens on Glucose and Lipids in Postmenopausal Prediabetic Women Veterans

CE/BZA
Start date: April 8, 2024
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the effect of a novel menopause hormone therapy on blood sugar (glucose) and blood and liver fats (lipids) in obese menopausal women Veterans.

NCT ID: NCT05070741 Terminated - PreDiabetes Clinical Trials

Heat Shock Therapy to Improve Mitochondrial Function in Neuropathy

HOTFUN
Start date: July 27, 2020
Phase: N/A
Study type: Interventional

Sensory dysfunction as a result of peripheral nerve damage is a significant problem that leads to reduced quality of life for patients. The prevalence of sensory dysfunction in peripheral neuropathy associates with epidemic increases in prediabetes and diabetes, but also is relevant to chemotherapy treatments and genetic disorders. Clinical approaches to treat peripheral neuropathy and to stimulate axon growth in settings of peripheral axon loss are limited. Although new drugs will hopefully be forthcoming, the most promising approaches likely involve behavioral and lifestyle interventions. Mitochondrial dysfunction is emerging as a key cellular contribution to peripheral axon health and peripheral neuropathy. Mitochondrial deficiencies contribute to neuropathy and include impaired mitochondrial problems with trafficking, mitophagy, fission, and biogenesis. All of these are thought to lead to a bioenergetic crisis, ending in distal axonal degeneration, sensory dysfunction and pain. Heat shock proteins play a critically important role in cellular homeostasis and increasing heat shock protein functions within cells leads to a range of positive improvements, particularly in mitochondria. In addition, new evidence suggests that increasing heat shock protein responses in peripheral nerves has powerful, positive impacts on sensory function and neuropathy. Our interdisciplinary team will investigate the role of mitochondrial dysfunction in peripheral neuropathy and translate these approaches to improve treatment for patients with peripheral neuropathy. The investigators hypothesize that novel heat treatment interventions that improve mitochondrial function will improve metabolic symptoms and peripheral nerve mitochondria, leading to improvements in sensory function, via heat shock protein induction. The investigators will employ immersion heat treatment to elevate heat shock protein responses that induce positive changes in peripheral nerve mitochondria. One aspect is to confirm the efficacy, safety, and potential for heat treatment to improve sensory dysfunction in human patients with prediabetes. The goal of this proposal is 1) to test the breadth of heat treatment on various forms of neuropathy, 2) identify mechanisms in which heat treatment improves mitochondrial function, and 3) test the efficacy, safety, and potential for heat treatment to improve sensory dysfunction in human patients with prediabetes.

NCT ID: NCT05067621 Recruiting - Clinical trials for Type 2 Diabetes Mellitus

Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

Start date: July 17, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to understand the role of GLP-1 in the pathogenesis of T2D in youth and explore their potential salutary effects and ability to delay the progressive loss of ß-cell function and reduce hepatic steatosis in youth with prediabetes/new onset T2D and NAFLD.

NCT ID: NCT05066542 Active, not recruiting - Type 2 Diabetes Clinical Trials

Recreational Basketball to Increase Participation in Diabetes Prevention

DPPHoops
Start date: June 11, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the efficacy of adapting the National Diabetes Prevention Program (NDPP) to include recreational sports in effort to increase physical activity (PA) and promote lifestyle changes that can help reduce the risk of developing Type 2 Diabetes Mellitus. The hypothesis is that both the traditional NDPP and the NDPP+ Basketball will be considered feasible. The primary outcome is to assess whether the intervention (NDPP+BB) compared to the standard of care (NDPP only) will result in greater weight loss, lower A1c, and increased engagement in physical activity.

NCT ID: NCT05058690 Not yet recruiting - Diabetes Mellitus Clinical Trials

Artificial Intelligence to Improve Cardiometabolic Risk Evaluation Using CT Scans

ACRE-CT
Start date: March 1, 2024
Phase: N/A
Study type: Interventional

To validate the ability of the FatHealth algorithm to identify individuals with pre-diabetes and with type 2 diabetes mellitus

NCT ID: NCT05056376 Active, not recruiting - Obesity Clinical Trials

Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this research study is to compare the effectiveness of a fully automated digital diabetes prevention program to standard of care human coach-based diabetes prevention programs for promoting clinically meaningful lifestyle changes to reduce the risk of type 2 diabetes in adults with prediabetes.

NCT ID: NCT05055219 Completed - PreDiabetes Clinical Trials

Conventional and Metabolomic Predictors of Prediabetes & Insulin Resistance

Start date: June 2015
Phase:
Study type: Observational

The purpose of this study is to evaluate the longitudinal test performance of an array of conventional biomarkers of glycemia, including Hemoglobin A1c (HbA1c), and novel metabolomic biomarkers for identifying progression of glucose tolerance (normal to prediabetes or prediabetes to diabetes) in an overweight and obese pediatric cohort.

NCT ID: NCT05052918 Recruiting - Atherosclerosis Clinical Trials

The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes

Start date: September 8, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate whether there is a change in carotid intima media thickness with the application of guide-based exercise programs in individuals with prediabetes, and to evaluate whether there is a difference between the group in which exercise programs were applied and those who received only lifestyle change and metformin.

NCT ID: NCT05051436 Recruiting - Obesity Clinical Trials

The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

Start date: December 13, 2021
Phase: Phase 4
Study type: Interventional

The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further improved by combination therapy with tadalafil. The investigator will comprehensively analyze glucose homeostasis in prediabetic patients treated for 14 weeks with mirabegron, tadalafil or both drugs as compared to a placebo.