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Pneumonia clinical trials

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NCT ID: NCT06423560 Completed - COVID-19 Clinical Trials

Pulmonary Fibrosis After Severe COVID-19 Pneumonia

SPIFFERO
Start date: March 1, 2020
Phase:
Study type: Observational

Patients discharged after hospitalization for COVID-19 pneumonia were retrospectively selected by radiologically established criteria that at admission presented at chest computed tomography (CT) (i) normal lung parenchyma <50% of total lung volume; and/or (ii) area of lung consolidation > 10%. All At discharge and after 9 months, all subjects underwent cardiological evaluation, echocardiogram, pulmonary function tests (PFT) both atby 3 and by 12 months after discharge. Chest CT was performed by 12 months after discharge and chest CT. Specifically, the magnitude of pulmonary involvement between baseline and follow-up was considered the primary endpoint of this study. Secondary endpoints of the study were results of respiratory function testing, echocardiographic parametersparameters, and persistence of symptoms.

NCT ID: NCT06410664 Not yet recruiting - Clinical trials for VAP - Ventilator Associated Pneumonia

Efficiency and Safety of the Prolonged Use of Heat and Moisture Exchangers in ICU

FILTRex
Start date: May 2024
Phase: N/A
Study type: Interventional

FILTRex is a single-centre, controlled, randomised, prospective, non-inferiority clinical trial to compare the efficiency and safety of prolonged (72-hours) versus standard (24-hours) duration of use for Heat and Moisture Exchange (HME) filters in adult mechanically ventilated critically ill patients

NCT ID: NCT06395740 Recruiting - Clinical trials for Aspiration Pneumonia

Aspiration Pneumonia in Cerebrovascular Stroke Patients Suffering From Bulbar Palsy

TPN
Start date: May 5, 2024
Phase: Phase 4
Study type: Interventional

One of the most serious complications in the critically ill patient complaining of bulbar palsy is aspiration pneumonia. These patients are scheduled for nasogastric tube feeding trying to avoid recurrent aspiration and subsequent aspiration pneumonia. Even though, the risk of aspiration is still present. Putting a total parenteral nutrition regimen for these patients is a supposed strategy to avoid aspiration pneumonia till recovery from bulbar palsy or planning for tracheostomy and or feeding gastrostomy.

NCT ID: NCT06392451 Not yet recruiting - Clinical trials for Coronavirus Disease 2019

LIAISON NES Influenza (FLU) A/B, Respiratory Syncytial Virus (RSV), & Coronavirus Disease 2019 (COVID-19) in Symptomatic Patients in Australia

Start date: May 6, 2024
Phase: N/A
Study type: Interventional

To establish the relative accuracy of the LIAISON® NES Flu A/B, RSV & COVID-19 assay for viral nucleic acid targets from professionally collected or patient self-collected dry nasal (NS) swabs and to establish the relative accuracy of the LIAISON PLEX® RSP Flex assay from NS and nasopharyngeal swabs (NPS) in applicable transport media from human patients exhibiting clinical signs and symptoms of a respiratory tract infection.

NCT ID: NCT06377163 Completed - Clinical trials for Children Chest Infection

Bacterial Pathogens Associated With Community-acquired Pneumonia in Children

Start date: January 1, 2021
Phase:
Study type: Observational

Pediatric community acquired pneumonia (CAP) is one of the most common reasons for hospital admission, there is no reliable way of distinguishing the causative organism based on clinical features. This study examined common pathogens of community-acquired pneumonia from 28 days up to 10 years in Dakahlia Governorate.

NCT ID: NCT06373939 Not yet recruiting - Asthma Clinical Trials

Performance and Safety of the Pneumoscope Device in Adults and Children

Start date: April 15, 2024
Phase: N/A
Study type: Interventional

Respiratory diseases are associated with high morbidity and mortality worldwide. Proper diagnosis and risk assessment of these conditions are essential for optimal management. Clinicians use three particularly useful tools to identify these conditions when assessing the patient's status: the stethoscope, the pulse oximeter, and the thermometer. The Pneumoscope is an all-in-one device including a digital stethoscope, a pulse oximeter, and a thermometer. This study aims to assess the performance and safety of the Pneumoscope in recording respiratory sounds, body temperature, non-invasive blood oxygen saturation levels and heart rate in children and adults.

NCT ID: NCT06370598 Not yet recruiting - Clinical trials for Pneumonia, Ventilator-Associated

Phase 1/2a to Assess the Safety and Tolerability of TP-122A for the Treatment of Ventilator-Associated Pneumonia

RECOVER
Start date: September 2024
Phase: Phase 1/Phase 2
Study type: Interventional

Given the challenges of treating complex cases of VAP caused by P. aeruginosa and K. pneumoniae, TechnoPhage developed a bacteriophage cocktail (TP-122) against those pathogens, aiming to provide a hospital-based add-on therapy to the SoC including antibiotic therapy, administered by nebulization. TP-122 is a bacteriophage cocktail divided in two different components: TP-122A is comprised of three bacteriophages against infections caused by Pseudomonas aeruginosa and TP-122B includes three bacteriophages against K. pneumoniae . For this study, an effective sample of 15 subjects will be randomly allocated into two arms, in a 3:2 ratio, with 9 subjects receiving TP-122A, in addition to SoC, and 6 subjects receiving the SoC alone.

NCT ID: NCT06364514 Not yet recruiting - Pneumonia Clinical Trials

PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

Start date: July 1, 2024
Phase: N/A
Study type: Interventional

To determine if clinicians can safely reduce antibiotic exposure in children with medical complexity (CMC) who are diagnosed with pneumonia by implementing an intervention that bases total antibiotic duration on an individual's clinical stability.

NCT ID: NCT06360770 Completed - Sepsis Clinical Trials

Assessement of Microcirculation With NIRS Predicts Sepsis Development in Patients With Severe Covid-19 Pneumonia

Start date: December 1, 2021
Phase:
Study type: Observational

Sepsis and septic shock are among main causes of death in patients with severe Covid-19 pneumonia. A few factors are proven to predict sepsis in these patients. WIth near infrared spectroscopy it is possible to detect microcirculatory changes typical for sepsis early in the course of disease. The hypothesis that changes in tissue oxygene saturation during vasoocclusive test predict sepsis as well as mortality in mechancally ventilated patients withe severe Covid-19 pneumonia will be tested.

NCT ID: NCT06360627 Recruiting - Lung Cancer Clinical Trials

Ultra Low Dose CT and Use of Iomeron 400 in PCD-CT

Start date: February 20, 2023
Phase: N/A
Study type: Interventional

Evaluation of ultra low dose protocols and Iomeron 400 contrast in PCD-CT