View clinical trials related to Physical Exercise.
Filter by:This study aims to determine the acute and chronic effects of high and low-intensity strength training on cardiac autonomic control in hypertensive subjects
The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers. This proposal will advance knowledge on how exercise may modulate the neurocircuitry of addiction. Uncovering the neurobiological mechanisms underlying the interactive neural effects of exercise and alcohol intake may provide additional scientific insights for the development of preventive and intervention programs for youth BD and AUD.
This study aims to compare the effects of aerobic exercise with or without addition of resistance exercise to usual care in individuals treated with anthracyclines for lymphomas and to compare exercise effects to age- and sex-matched individuals with no prior history of malignant diseases.
Patients with post-Covid-19 syndrome are at high risk of developing cardiovascular diseases 12 months after acute infection of COVID-19. We recently revealed that these patients have elevated muscular sympathetic nerve activity (MSNA), vascular dysfunction, impaired cardiac diastolic function, and reduced functional capacity. Considering that these outcomes are independent predictors of cardiovascular mortality, it is urgent to restore the cardiovascular health of these patients. High resistance inspiratory muscle strength training (IMST) at 75% of pressure inspiratory (PImax) performed at home (5 min/session, 5-7 times/week per 6 weeks) reduces the MSNA, improves the endothelial function and lowers blood pressure in different populations. Based on these findings, IMST (75% PImax) is an excellent therapeutic option for patients with post-COVID-19 syndrome. Therefore, the aim of the present proposal is to test whether IMST (75% PImax) reduces sympathetic activity, improves vascular function, and restores cardiac function, evoking an increase in functional capacity in patients with post-COVID-19 syndrome. To test these hypotheses we will conduct a randomized, double-blind, sham-controlled clinical trial to test these hypotheses.
A randomized controlled trial that uses a Stage-matched intervention based on the Transtheoretical Model of Change to enhance engaging in regular physical exercise among high school female students.
Motor learning is crucial for human daily routine, involving the acquisition of new movements. It consists of an online acquisition phase followed by offline consolidation, where motor memory is organized into stable representations. Acquisition can be achieved through physical practice (PP, overt repetition of movement) or mental rehearsal using motor imagery (MI). Recent studies suggest that high-intensity interval physical exercise (HIIE) enhances motor learning, particularly during consolidation, by promoting neural plasticity mediated by brain-derived neurotrophic factor (BDNF). However, the impact of HIIE on sequential motor consolidation with PP or MI remains poorly understood. In contrast, sleep deprivation (SD) reduces BDNF release and neural plasticity. Limited research has explored the effects of SD on motor acquisition, especially sequential motor learning. Considering the opposing effects of HIIE and SD, performing HIIE after SD may protect motor consolidation processes. This study aims to examine the influence of HIIE on sequential motor learning using PP or MI under both sleep-deprived and normal sleep conditions. Six groups, each comprising 12 participants, will learn an 8-item bimanual sequence. - MI group: acquired the motor sequence mentally during training - MI+HIIE group: acquired the motor sequence mentally and achieve a HIIE before the consolidation - PP: acquired the motor sequence physically - PP+HIIE group: acquired the motor sequence physically and achieve a HIIE before the consolidation - SD+PP group: one night of sleep deprivation prior physical motor acquisition with PP and consolidation - SD+PP+HIIE group: one night of sleep deprivation prior physical motor acquisition and HIIE before consolidation. All groups will be tested on the sequence at the beginning and the end of the acquisition phase (pre- and post-acquisition), and after the physical exercise (i.e. HIIE) or the rest period (post-exercise). Hypothesis of this study are : - Acute physical exercise (HIIE) would enhance the consolidation of motor memory (post-exercise) after physical and mental acquisition (PP,MI) compared to conditions without exercise. - One night of sleep deprivation would affect the acquisition and consolidation of motor learning. Physical exercise would compensate for the detrimental effects of sleep deprivation on the consolidation of motor learning.
Background: Heart failure (HF) is a chronic disease with a very important and increasingly severe social and health impact with a prevalence of 6.8% in Spain. HF with preserved ejection fraction (HFpEF) represents approximately 50% of all patients with HF. In the absence of pharmacological treatments that have succeeded in reducing mortality or morbidity in this pathology, it is recommended that interventions be directed at prevention, symptomatic treatment of HF and treatment of comorbidities to avoid exacerbations, thus physical exercise is recognized as an important adjunct in the treatment of HF and is recommended by the guidelines of the American College of Cardiology (ACC)/American Heart Association (AHA) and the European Society of Cardiology (ESC). Currently, aerobic exercise is the most studied physical exercise in this population, but in recent years high-intensity interval training (HIIT) and the combination of aerobic exercise with strength training (combined exercise) have emerged. Objectives: The overall objective of this study is to compare the effectiveness of combined training and HIIT on exercise capacity, diastolic function, endothelial function, and arterial stiffness in patients with HFpEF. The specific objectives of this study are: a) to compare the effectiveness of combined training and HIIT on quality of life in patients with HFpEF and b) to analyze the cost-effectiveness of combined training and HIIT versus conventional treatment in patients with HFpEF. Methodology: The ExIC-FEp study will be a single-blind randomized clinical trial with 3 arms (combined exercise, HIIT and a control group), conducted at the Health and Social Research Center of the University of Castilla-La Mancha, to analyze two types of supervised physical exercise in patients with HFpEF for 6 months. Patients with HFpEF will be randomly assigned (1:1:1) to the combined exercise, HIIT or control group. All participants will be examined, at baseline (prior to randomization), at three months (mid-intervention) and at six months (at the end of the intervention). Participants will undergo physical examination, echocardiography, maximal cardiopulmonary stress test, and measurement of endothelial function and arterial stiffness. In addition, sociodemographic variables, quality of life, physical activity, adherence to the Mediterranean diet, strength, spirometry and blood sampling will be measured. Expected scientific contributions: this randomized clinical trial will represent a a significant advance in the scientific evidence available on the efficacy of physical exercise in the treatment of HFpEF, through: (a) transfer of the results to physicians, nurses and patients; (b) dissemination of results through scientific articles, doctoral theses and participation in congresses; (c) press releases and press conferences with the aim of disseminating the research results to the population; (d) dissemination through social networks to improve the social impact; and (e) design and content development of a web page.
Through interview, taking the elderly community in Beijing as an example, this study will try to further understand the current physical exercise situation of the elderly in the community, and analyze the factors influencing their participation degree. By this way, we will try to provide constructive suggestions for the development and design of universal community physical exercise programs for the elderly.
Objective. In this study, the investigators aimed to investigate the efficacy of combined a single platelet-rich plasma (PRP) and physical exercise (leg swing and quadriceps strengthening exercise) versus PRP and hyaluronic acid (HA) combination therapy. Methods. One hundred and six patients with grade Ⅱ-Ⅲ Knee osteoarthritis (KOA) according to the Kellgren-Lawrence classification were randomly divided into intra-articular injection of PRP combined with leg swing and quadriceps strengthening exercise (group A) and intra-articular combination injections of PRP and HA (group B). Patients in group A received twice intra-articular injection of PRP (2 ml, 2 weeks apart) and regular leg swing and quadriceps strengthening exercise for 3 months. Patients in group B received twice intra-articular combination injections of PRP (2 ml) and HA (2 ml) every 2 weeks. The primary outcome measures were Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities (WOMAC) score. The second outcomes included single leg stance test (SLS) and functional activity by 2 minutes walking test (2MWT) and time up and go test (TUGT). All outcomes were evaluated at baseline and after 1,3,6, and 12 months.
The aim of this study is to evaluate the effect of Pilates exercise and Whatsapp text message-based support program on PMS symptoms experienced by university female students.