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Pain, Postoperative clinical trials

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NCT ID: NCT04728386 Not yet recruiting - Necrotic Pulp Clinical Trials

Postoperative Pain and Antibacterial Efficacy After Root Canal Irrigation With Curcumin or Sodium Hypochlorite

Start date: January 2021
Phase: N/A
Study type: Interventional

This study aims to compare the effect of 2% curcumin solution versus 2.5% sodium hypochlorite as irrigating solutions in necrotic mandibular molars in terms of postoperative pain and antibacterial effect.

NCT ID: NCT04719585 Not yet recruiting - Clinical trials for Osteoarthritis, Knee

Comparison of Opioid and Duloxetine for Postoperative Pain Control After Total Knee Arthroplasty: RCT

Start date: January 2021
Phase: N/A
Study type: Interventional

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) has recently been reported to be effective in controlling pain in persistent chronic pain caused by joint surgery and arthritis. However, opioids are important drugs that still play a pivotal role in pain control after surgery. In this study, we want to investigate the difference of the result among patients who undego total knee arthroplasty (TKA), of the result of pain control after TKA from SNRI administration of duloxetine and opioid in two groups. We designed a randomized controlled study (RCT) for the effect of post-TKA pain control to determine whether SNRI is effective in controlling post-TKA pain compared to Opioid, and whether there is a difference in side effects.

NCT ID: NCT04719507 Not yet recruiting - Pain, Postoperative Clinical Trials

Erector Spinae Block Versus Thoracic Paravertebral Block for Postoperative Pain Control After Open Nephrectomy

Start date: January 2021
Phase: N/A
Study type: Interventional

the study aims to compare the analgesic efficacy of erector spinae plane block versus thoracic paravertebral block after open nephrectomy surgery.

NCT ID: NCT04702685 Not yet recruiting - Pain, Postoperative Clinical Trials

Erector Spinae Plane Block With Ropivacaine for Major Upper Abdominal Surgery

Start date: January 2021
Phase: Phase 3
Study type: Interventional

Prospective, single-centre, randomized, controlled, open-label, evaluator-blinded, superiority trial.

NCT ID: NCT04697745 Not yet recruiting - Pain, Postoperative Clinical Trials

Dexamethasone and Dexmedetomidine as an Adjuvant to Spinal Anesthesia for Elective Caesarean Sections

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The main objective of our study is to evaluate analgesic effect of intrathecal dexamethasone and dexmedetomidine in elective caesarean sections

NCT ID: NCT04650737 Not yet recruiting - Stone, Kidney Clinical Trials

Single-Shot With Dexmedetomidine Versus Continuous Ultrasound-guided Erector Spinae Plane Block for Postoperative Pain Control After Percutaneous Nephrolithotomy

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

The current study is designed to assess the efficacy of a single shot ESPB with Dexmedetomidineversus continuous ESPB in perioperative analgesia for PCNL. Both techniques are conducted for patients undergoing PCNL under GA.

NCT ID: NCT04631822 Not yet recruiting - Pain, Postoperative Clinical Trials

Comparing Dexamethasone With Dexmedetomidine as Additives to Bupivacaine in Adductor Canal Block for Knee Arthroscopy.

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

a comparison shall be conducted between dexamethasone accompanied by bupivacaine, on one hand, and dexmedetomedine accompanied by bupivacaine, on the other hand for pain-free knee arthroscopic surgeries.

NCT ID: NCT04627779 Not yet recruiting - Postoperative Pain Clinical Trials

Sex Difference in Preemptive Analgesic Effects With Flurbiprofen Axetil on Postoperative Pain and Sleep Quality

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

In humans and animals, circadian rhythm sleep cycle plays an important role on maintaining and regulating basic physiological homeostasis, such as cognitive function, glucose metabolism, memory consolidation, immune function and growth hormone secretion. The induction of general anesthesia leads to a state of reduced responsiveness, which is often described by anesthesiologists and patients as "sleep". This seems to be a common problem in the case of patients under general anesthesia, besides surgery trauma and general anesthetics may change sleep function and sleep cycle perioperatively, the postoperative complications such as pain, nausea and vomiting etc after general anesthesia may also reduce postoperative sleep quality.Flurbiprofen axetil is a new non-steroidal anti infection analgesic(NSAIDs), which is widely used for analgesia to reduce the dose of opioids and the occurrence of adverse reactions, such as declined sleep quality, respiratory depression, nausea and vomiting . Preemptive analgesia is an analgesic intervention that begins before surgery to prevent the nervous system from becoming sensitive to subsequent stimuli that may aggravate pain. A large number of experimental studies have shown that use flurbiprofen axetil preoperatively is better than use it postoperatively. However, limited information was reported before on the effect of factors such as age, gender, preoperative negative mood such as anxiety and depression, type and length of surgery, which could influence postoperative pain and analgesic consumption and the association between postoperative sleep quality and postoperative pain intensity. At present, there has been less previous evidence for how preemptive analgesic with flurbiprofen axetil affect postoperative sleep quality through its effect on postoperative pain of patients with different sex under general anesthesia.

NCT ID: NCT04622488 Not yet recruiting - Post Operative Pain Clinical Trials

The Effect of Diclofenac Potassium Insitu Gel Vs Calcium Hydroxide as Intra-canal Medications on Post-operative Pain and Anti-bacterial Effect

Start date: November 2020
Phase: N/A
Study type: Interventional

The aim of this study is to clinically compare the post-operative pain level and antibacterial effect when using the Diclofenac Potassium Insitu gel versus calcium hydroxide as an intra- canal medication in patients with apical periodontitis.

NCT ID: NCT04616469 Not yet recruiting - Postoperative Pain Clinical Trials

Evaluation of the Effect of Root Canal Shaping With TruNatomy on Postoperative Pain and Operative Torque Generated During Instrumentation

Start date: November 1, 2020
Phase: N/A
Study type: Interventional

The aim of the present study is to compare the effect of canal shaping using TruNatomy and RaCe rotary systems in bi-rooted maxillary premolars in terms of: - Post operative pain: incidence and intensity - Real time torque generated during mechanical instrumentation using real time torque motoring endodontic motor - Time needed for the instruments to reach to the full working length