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Anesthesia clinical trials

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NCT ID: NCT05206110 Not yet recruiting - Surgery Clinical Trials

Low Dose Versus Normal Dose Ketorolac for Postoperative Pain After Prostatectomy and Hysterectomy

Start date: February 14, 2022
Phase: N/A
Study type: Interventional

A monocenter, prospective, double-blind, randomized controlled non-inferiority trial will be designed to investigate if ketorolac 10 mg is as effective for pain relief as the standard dose of 30 mg in patients undergoing robot assisted radical prostatectomy (RARP) or hysterectomy by laparoscopic assisted vaginal hysterectomy (LAVH) or total laparoscopic hysterectomy (TLH). It is hypothesised that the postoperative pain score at rest at 8 hours after surgery when receiving ketolorac 10 mg is non-inferior to the pain score at rest when receiving ketolorac 30mg.

NCT ID: NCT05199883 Completed - Anesthesia Clinical Trials

The TI.VA Algorithm: A First-in-Humans Test.

TIVAly
Start date: December 1, 2020
Phase: N/A
Study type: Interventional

The TI.VA algorithm is a new method to titrate the anesthetic drug concentrations whenever the planned level of anesthesia results to be not appropriate to blunt the patient's reaction to surgical stimulation. TI.VA is a multiple inputs/multiple outputs algorithm. The control variables are the bispectral index (BIS) and the mean arterial pressure (MAP) combined in a decision-making matrix. The optimal range for the two control variables (BIS: 540-60 and MAP: 65-75 mmHg) identified the Optimal Anesthesia Zone (OAZ) at the center of the matrix. Any time one or both control variables escape from the PAZ, the algorithm proposes an intervention on the hypnotic and/or opioid levels (algorithm outputs). A First-in-Humans study was designed to capture preliminary data on the safety and performance of the TI.VA algorithm.

NCT ID: NCT05193097 Not yet recruiting - Anesthesia Clinical Trials

Vasopressor Preload Modulation During General Anaesthesia

Start date: January 3, 2022
Phase:
Study type: Observational

Is is debated whether administration of pure vasopressor may augment cardiac output (CO) by means of preload modulation. We wish to test this in 20 patients under general anesthesia, with preload dependency induced by head-up-tilt and preload modulation with infusion of phenylephrine. To document any changes in CO the patients will be monitored by Lithium dilution method. Furthermore we will monitor changes in peripheral perfusion index and test the ability of this non-invasive modality to track changes in CO.

NCT ID: NCT05191966 Not yet recruiting - Anesthesia Clinical Trials

Subcostal Approach to Anterior Quadratus Block Versus Thoracic Paravertebral Block for Laparoscopic Nephrectomy

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

In this study, it was aimed to evaluate the effects of subcostal anterior quadratus lumborum block (S-QLB3) and thoracic paravertebral block (TPVB) on postoperative acute pain scores and opioid consumption in the first 24 hours after laparoscopic nephrectomy surgery.

NCT ID: NCT05191953 Not yet recruiting - Anesthesia Clinical Trials

ESPB vs.Combination of ESPB and Superficial PIPB in Cardiac Surgery

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

Cardiac surgery is associated with significant postoperative pain. Pain control is an essential part of enhanced recovery protocols. The aim of this study is to evaluate and compare the analgesic efficacies of erector spinae plane block (ESPB) and the combination of ESPB and superficial parasternal intercostal plane block (PIPB) in patients undergoing elective cardiac surgery.

NCT ID: NCT05189431 Completed - Anesthesia Clinical Trials

Peripheral Perfusion Index During Induction of Anaesthesia

Start date: July 1, 2018
Phase:
Study type: Observational [Patient Registry]

We wish to study the feasibilty of using the peripheral perfusion index as a supplementary monitor during induction of general anesthesia

NCT ID: NCT05188547 Not yet recruiting - Anxiety Clinical Trials

Information Retention After Video (Augmented) Preoperative Anesthesiological Education

Start date: February 2022
Phase: N/A
Study type: Interventional

Patient education is continuously becoming more important to enable patients to participate in making decisions regarding their medical treatment. Specifically, this is also the case for preoperative education on anesthesia. Worldwide, there are many initiatives to improve preoperative patient education and subsequent level of knowledge of anesthesia, for example by using digital aids. The demand for such aids has increased significantly since the start of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic to facilitate remote preoperative anesthesiological screening. Although many videos to educate patients on anesthesia have been developed and circulate on the internet, there has been little effort to compare this method of educating patients with the traditional one-on-one conversation between the anesthesiologist and the patient. Objective: To compare short, mid-and long term retention of knowledge after education on anesthesia by watching a video to the traditional one-on-one explanation by the anaesthesiologist.

NCT ID: NCT05187039 Recruiting - Anesthesia Clinical Trials

Bariatric Electrical Impedance Tomography

Start date: October 19, 2021
Phase:
Study type: Observational

This study investigates under controlled conditions the variation of poorly ventilated lung units (silent spaces) in obese patients scheduled for laparoscopic bariatric surgery in the perioperative phase.

NCT ID: NCT05185167 Not yet recruiting - Anesthesia Clinical Trials

Comparison of the Genotoxicity of Desflurane and Propofol

Start date: January 15, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.

NCT ID: NCT05177159 Recruiting - Anesthesia Clinical Trials

Postoperative Delirium and Its Biomarkers in Elderly Patients Undergoing Non-cardiac and Non-neurosurgery.

Start date: November 10, 2018
Phase:
Study type: Observational

Postoperative delirium (POD) is a common complication in elderly patients and is associated with negative clinical outcomes, such as prolonged hospitalizations, cognitive impairment, and higher mortality rate. While the pathophysiology of delirium remains unknown, the cerebral hypoperfusion and neuroinflammatory response are considered to play an important role in the process of POD. The aim of the study is to determine the association between POD and biomarkers in elderly patients undergoing noncardiac and non-neurological surgery.