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Osteoarthritis, Knee clinical trials

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NCT ID: NCT06163755 Withdrawn - Clinical trials for Osteoarthritis, Knee

Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis.

Start date: January 1, 2018
Phase: Phase 2
Study type: Interventional

Prospective randomized double-blind controlled study. Participating patients with knee pain secondary to knee osteoarthritis will be randomized to either the DepoMedrol 40mg + 0.25% Bupivacaine (total Volume 5 ml) vs Morphine 3mg group+0.5% Bupivacaine (total volume 5ml) for their intra-articular knee injection. Before the injections, baseline values of NRS (Numerical rating scale) and WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) Questionnaire will be recorded by investigator. After the injections NRS and WOMAC will be recorded at 30mins and on discharge. Patient will be contacted by phone to assess the effectivity of block or any side effects on day 1, 7,30 and 45, information including NRS (at rest and household activity), WOMAC, supplemental analgesic, Side effects (pruritus, paresthesia, urinary retention, nausea, vomiting, dizziness, rash) will be obtained from the patient at the above time intervals. follow up visit will be scheduled 60days after the procedure for re-evaluation.

NCT ID: NCT05632783 Withdrawn - Knee Osteoarthritis Clinical Trials

TreatMent Of Knee osTeoarthritis wIth chONdroitin Sulfate - the OA MOTION Study

MOTION
Start date: December 2023
Phase: Phase 3
Study type: Interventional

The goal of this phase III study is to evaluate the efficacy, safety, and tolerability of chondroitin sulfate 800 mg oral tablets versus placebo in the treatment of subjects with pain due to knee OA (osteoarthritis). The further aims of the study are to evaluate the durability of the treatment effect (up to week 36) and to gain further long-term safety and efficacy data (up to 48 weeks). The primary outcome of interest will be the effect of chondroitin sulfate on pain in the index knee at week 24 compared to placebo. The effect of chondroitin sulfate in the index knee functionality and the patient global impression of changes at 24 weeks compared to placebo are included as key-secondary endpoints. An additional key secondary endpoint will assess the durability of the effect on pain compared to placebo at week 36. Several additional secondary endpoints are included to further support the beneficial effect of the treatment and the improvements in patient's quality of life (i.e., Western Ontario and McMaster Universities Arthritis Index -WOMAC- subscales and total scores at each study visits, changes in patient's quality of life, use of rescue medication etc.) other than the safety of the product.

NCT ID: NCT05482672 Withdrawn - Depression Clinical Trials

GetHealthy-OA: A Program to Improve Pain and Function for Patients With Knee Osteoarthritis, Obesity, and Depression

Start date: April 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The investigators have previously identified knee osteoarthritis patients with the combination of depression and an unhealthy weight may be an increased risk of more rapid joint degeneration and worsening pain. The GetHealthy-OA program combines a mind-body program with the oral supplement fisetin to potentially reduce the risk for this population by treating psychosocial, mechanical, and inflammatory mechanisms of knee osteoarthritis. This randomized clinical trial will compare the GetHealthy-OA program to minimally-enhanced usual care plus an oral placebo.

NCT ID: NCT05461638 Withdrawn - Knee Osteoarthritis Clinical Trials

Kinematic Alignment vs Mechanical Alignment for Total Knee Arthroplasty

KA vs MA
Start date: January 5, 2020
Phase: N/A
Study type: Interventional

This is a prospective, randomized, single-blinded, multi-center trial comparing Kinematic Alignment vs Mechanical Alignment in TKA patients using patient reported outcomes, clinical and functional performance tests and radiographic analyses.

NCT ID: NCT05374330 Withdrawn - Knee Osteoarthritis Clinical Trials

Electroacupuncture Treatment for Those With End Stage Knee Osteoarthritis on a Total Knee Arthroplasty Waitlist

Start date: September 2023
Phase: N/A
Study type: Interventional

A 3-armed pilot randomized controlled trial: electroacupuncture, sham acupuncture and waitlist groups.

NCT ID: NCT05330689 Withdrawn - Clinical trials for Osteoarthritis, Knee

How Does Platelet Dose Impact Clinical Outcomes After PRP Treatment?

Start date: March 6, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine which platelet rich plasma (PRP) injection dosage provides the most improvement in a patient's knee pain level at 26 weeks post-injection.

NCT ID: NCT05202847 Withdrawn - Knee Osteoarthritis Clinical Trials

Clinial Application of Park et al.(The Knee 27 (2020) 1577-1584)'s Study

Start date: December 7, 2022
Phase: N/A
Study type: Interventional

The goal of this study was to perform pulsed radiofrequency ablation with a modified target suggested in the cadaver study by Park et al. (The Knee 27 (2020) 1577-1584) on knee osteoarthritis patients, and to evaluate the effect of reducing the frequency of intravascular injection and reducing pain.

NCT ID: NCT05179044 Withdrawn - Clinical trials for Osteo Arthritis Knee

Utilization of a Knee Brace With Extension Swing

Start date: February 7, 2022
Phase: N/A
Study type: Interventional

The purpose of this research is to help determine if use of the Guardian brace during prehab and post-op rehab after TKA can help improve functional outcomes and reduce the incidence of post-operative flexion contractures which reduce knee range of motion after surgery.

NCT ID: NCT05097729 Withdrawn - Chronic Pain Clinical Trials

rTMS for Relieving Chronic OA Pain

Start date: November 15, 2021
Phase: N/A
Study type: Interventional

In this study the investigators aim to examine the effects of Transcranial Magnetic Stimulation (TMS) on hippocampal network connectivity and pain levels in individuals with pain due to knee osteoarthritis.

NCT ID: NCT05054595 Withdrawn - Pain Clinical Trials

Audio-Recorded vs. Nurse-Led Brief Mindfulness-Based Intervention

Start date: September 20, 2021
Phase: N/A
Study type: Interventional

This is a single-site, three-arm, parallel-group randomized clinical trial (RCT). The clinical effects of a nurse-led, very brief, preoperative mindfulness-based intervention for hip and knee replacement patients will be investigated relative to an audio-recorded very brief, preoperative mindfulness-based intervention delivered during the standard nurse consult and a nurse-led preoperative pain psychoeducation intervention during the standard nurse consult.