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NCT06292897 Clinical Trial

Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Obesity Clinical Trial

— OBESITA'&PCa  

Official title:
Integrating Tissue-based Spatial Information to Elucidate How Obesity-induced Tumour Metabolites Drive Prostate Cancer Progression

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06292897
Other study ID # 3312
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date March 20, 2023
Est. completion date January 15, 2027

Study information
Verified date February 2024
Source Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Contact Giancarlo Albo, MD,
Phone 00390255034501
Email giancarlo.albo@policlinico.mi.it
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI > 27.5) and non-severely overweight/normoweight (BMI < 27.5) patients affected by prostate carcinoma. ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients. iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

Recruitment information / eligibility
Status Recruiting
Enrollment 25
Est. completion date January 15, 2027
Est. primary completion date September 15, 2026
Accepts healthy volunteers No
Gender Male
Age group 18 Years and older
Eligibility Inclusion Criteria: - affected by prostate cancer Exclusion Criteria: -

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• observational study
observational study

Locations
Country Name City State
Italy IRCCS Cà Granda Ospedale Maggiore Policlinico Milano Milan

Sponsors (2)
Lead Sponsor Collaborator
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico National Research Council

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary Assess the protein expression of LDHA enzyme and MCT-1/-4 transporters in prostate carcinoma 4 years
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