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Neoplasms clinical trials

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NCT ID: NCT06469671 Not yet recruiting - Colonic Neoplasms Clinical Trials

Effectiveness of Artificial Intelligence - Assisted Colonoscopy in Colorectal Neoplasms

ArtInCol
Start date: July 2024
Phase: N/A
Study type: Interventional

The primary goal of this study is to estimate the effectiveness of a medical decision support system based on artificial intelligence in the endoscopic diagnosis of benign tumors. Researchers will compare Adenoma detection rate between "artificial intelligence - assisted colonoscopy" and "conventional colonoscopy" groups to evaluate the clinical effectiveness of artificial intelligence model.

NCT ID: NCT06468358 Not yet recruiting - Solid Tumor Clinical Trials

A Study to Evaluate LB1410 in Combination With LB4330 in Patients With Advanced or Metastatic Solid Tumors

TRIGGERCD8
Start date: June 20, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This is a phase Ib/II, open, dose-escalation and expansion study of an anti-PD1/TIM3 bispecific antibody,LB1410 in combination with an anti-Claudin18.2/IL-10 fusion protein, LB4330 in patients with advanced or metastatic solid tumors.

NCT ID: NCT06468098 Recruiting - Clinical trials for Advanced Malignancies

A Study of IBI363 in Subjects With Advanced Malignancies

Start date: May 31, 2024
Phase: Phase 1
Study type: Interventional

This is an open-label, multicenter Phase Ib study to evaluate the safety, tolerability, and efficacy of IBI363 in advanced malignancies patients

NCT ID: NCT06466798 Not yet recruiting - Clinical trials for Recurrent Medulloblastoma

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Start date: July 1, 2024
Phase: Phase 1
Study type: Interventional

The goal of this clinical trial is to assess the safety, toxicity, and antitumor activity of fourth ventricular infusions of nivolumab plus 5-azacytidine for recurrent ependymoma and nivolumab plus methotrexate for recurrent medulloblastoma and other CNS malignancies. Additionally, the study will explore immunologic responses to nivolumab. The hypothesis is that local administration of nivolumab, an immune checkpoint inhibitor, is safe and will lead to even more robust treatment responses when administered following 5-azacytidine in patients with recurrent ependymoma or methotrexate in patients with medulloblastoma or other CNS tumors.

NCT ID: NCT06466382 Not yet recruiting - Clinical trials for Fallopian Tube Neoplasms

OV Precision: Study Examining the Benefit of a Tumor- and Patient-specific Cancer Therapy

OVPrecision
Start date: September 2024
Phase: N/A
Study type: Interventional

The long-term goal of this research project is to demonstrate whether HRD negative (HPR) patients benefit when additional multimodal biological tumor information is incorporated into the molecular tumor board (mTB) treatment recommendation process.

NCT ID: NCT06466265 Recruiting - Clinical trials for Advanced Solid Tumor

Study of DNP002 in Patients With Solid Tumors

Start date: May 24, 2021
Phase: Phase 1
Study type: Interventional

This is an open-label, Phase 1, first-in-human, dose-escalation study designed to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of the anti-Carcinoembryonic-antigen-related-cell-adhesion-molecule-6 (CEACAM6) antibody DNP002 in patients with advanced solid tumors.

NCT ID: NCT06466187 Not yet recruiting - Clinical trials for Carcinoma, Non-Small-Cell Lung

A Study of SGN-MesoC2 in Advanced Solid Tumors

Start date: August 15, 2024
Phase: Phase 1
Study type: Interventional

This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or has spread to other parts of the body, it is called unresectable. These types of cancer are harder to treat. Patients in this study must have cancer that has come back or did not get better with treatment. Patients must have a solid tumor cancer that can't be treated with standard of care drugs. This clinical trial uses an experimental drug called SGN-MesoC2. SGN-MesoC2 is a type of antibody-drug conjugate (ADC). ADCs are designed to stick to cancer cells and kill them. They may also stick to some normal cells. This study will have 3 parts. Part A and Part B of the study will find out how much SGN-MesoC2 should be given to participants. Part C will use the information from Parts A and B to see if SGN-MesoC2 is safe and if it works to treat solid tumor cancers.

NCT ID: NCT06466096 Not yet recruiting - Clinical trials for Postoperative Delirium

Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms Based on Rs-fMRI

Start date: June 20, 2024
Phase:
Study type: Observational [Patient Registry]

This is a prospective cohort study to explore the differences of resting-state functional magnetic resonance imaging (fMRI) between elderly gastrointestinal neoplasms patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD).

NCT ID: NCT06465433 Not yet recruiting - Clinical trials for Hematologic Malignancies

Extension Study to Provide Continued Treatment for Patients With Hematologic Malignancies Previously Enrolled in Studies With Tafasitamab

Start date: June 18, 2024
Phase: Phase 2
Study type: Interventional

This extension study is designed to enroll participants with hematologic malignancies who are receiving clinical benefit from tafasitamab treatment in a parent study with tafasitamab..

NCT ID: NCT06465199 Not yet recruiting - Ewing Sarcoma Clinical Trials

Difluoromethylornithine (DFMO) and AMXT-1501 for Neuroblastoma, CNS Tumors, and Sarcomas

Start date: July 2024
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the investigational drug AMXT 1501 (a pill taken by mouth) in combination with the drug difluoromethylornithine (DFMO) for infusion administered intravenously (IV; a liquid that continuously goes into your body through a tube that has been placed during a surgery into one of your veins). An investigational drug is one that has not been approved by the U.S. Food & Drug Administration (FDA), or any other regulatory authorities around the world for use alone or in combination with any drug, for the condition or illness it is being used to treat. The goals of this part of the study are: - Establish a recommended dose of AMXT 1501 in combination with DFMO for infusion - Test the safety and tolerability of AMXT 1501 in combination with DFMO for infusion in patients with cancer - To determine the activity of study treatments chosen based on: - How each subject responds to the study treatment - How long a subject lives without their disease returning/progressing