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The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters.

Obesity Clinical Trial

Official title:
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.

Clinical Trial Summary

The current study will test the central hypothesis that Glycine supplementation in humans improves Lipid profile and therefore reduces the risk of Atherosclerosis. Secondary outcomes including Insulin sensitivity and parameters related to Metabolic Syndrome (MetS) will also be measured. Furthermore, a mechanistic study in an ex-vivo model will test the hypothesis that Glycine via its key biosynthetic pathway involving Serine Hydroxymethyltransferase 2 (SHMT2), is athero-protective by inhibiting Sterol regulatory element-binding protein 2 (SREBP2)-mediated cholesterol biosynthesis in murine macrophage-like cell line.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03850314
Study type Interventional
Source Rambam Health Care Campus
Contact Tony Hayek, MD
Phone +972523782009
Email t_hayek@rmc.gov.il
Status Not yet recruiting
Phase Phase 2/Phase 3
Start date March 2019
Completion date June 2020
View Details
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