Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery

Obesity Clinical Trial

Official title:

Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03283644
• Other study ID #: ERN_13-0355
• Status: Completed
• Start date: June 2015
• Est. completion date: October 28, 2016

Study information

• Verified date: February 2017
• Source: University of Birmingham
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response

Description:

Inflammation is a central component of the immune response. In its acute form it aids the transition from disease to health via the activation of numerous immune cells, enabling them to reach the site of infection/injury and orchestrate themselves to combat pathogens, facilitating resolution and repair to restore the host to health. However, chronic inflammation is deleterious to the host and differs from the "classical" acute inflammatory process in that the inflammation is not necessarily so readily obvious and is not self-limiting; rather, the immune system is in a constant state of low-grade activation and when challenged by pathogenic or sterile injury the response is heightened, resulting in prolonged tissue damage and a failure of efficient resolution mechanisms.

Neutrophils are important mediators of acquired innate immune responses but may also contribute to the pathogenesis of chronic inflammatory diseases. Neutrophils are heavily involved in antimicrobial defence; their primary role is the localisation and elimination of pathogenic microorganisms. This, combined with their relatively short lifespan, has resulted in a traditional view of them as limited "kamikaze" cells. However, as detailed here, neutrophils have been shown to act with complexity and sophistication, orchestrating the immune/inflammatory response but also inadvertently contributing to tissue damage in different disease states. This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response

Recruitment information / eligibility

• Status: Completed
• Enrollment: 43
• Est. completion date: October 28, 2016
• Est. primary completion date: August 28, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria for Bariatric participants:

• BMI >40

• Undergoing Gastric Band surgery

Exclusion Bariatric Participants Criteria:

• Undergoing alternative weight loss surgery

• BMI<40

• Smoking

• Pregnancy

Exclusion criteria for the controls

• BMI over 27

• pregnancy

• smoking

• evidence of systemic disease

• use of medications/vitamin supplements.

Related Conditions & MeSH terms

• Inflammation
• Morbid Obesity
• Obesity
• Obesity, Morbid

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
University of Birmingham	Birmingham Heartlands Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Biochemical Markers associated with Inflamation	(IL-8, IL-1, ROS, Production of NETS)	OCT 2016