Obesity Clinical Trial
Official title:
A Role for Brown Adipose Tissue in Postprandial Thermogenesis?
Brown adipose (fat) tissue (BAT) is a type of fat tissue found in certain small rodents and
human babies that is capable of extremely high rates of energy burning. We now know that in
adult humans it is present and also able to burn energy.
In addition to increased energy expenditure during cold exposure, energy burning is also
increased after consuming a meal. Animal studies have shown that part of this additional
energy consumption is contributed by BAT. In the present study we will aim to examine
whether BAT activity is increased after a meal.
The purpose of this project is to measure whether BAT activity (during which BAT increases
energy burning) increases in response to ingestion of a meal.
BAT is one of two types of fat, (the other being white fat), which is found in humans and
other mammals. In this study we aim to further our understanding of how BAT works in humans.
Studies in animals show that in addition to cold exposure, BAT is also activated by
ingestion of a meal, and to different amounts depending on the meal composition, and more
importantly, total energy content. However we have only a very limited understanding of BAT
function in response to meals in humans. Since BAT function is defective in obesity, and its
activity and function are impacted by diet, here we will find out whether a single high
energy meal composed entirely of lipid (fat) can increase BAT activity. In future these
findings and those of subsequent studies may have important implications for the management
of obesity and related diseases.
A total of 20 people will participate in this project. Participation will involve a total of
3 visits, including a screening visit, 2 experimental visits consumption of the treatment
meal on one visit, and the placebo (dummy) on the other in a randomised order.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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