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Neuropathic Pain clinical trials

View clinical trials related to Neuropathic Pain.

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NCT ID: NCT05674240 Recruiting - Chronic Pain Clinical Trials

Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain

Start date: December 6, 2022
Phase:
Study type: Observational [Patient Registry]

This Registry study will prospectively evaluate the differences in treatment outcomes in terms of pain intensity, pain interference, concomitant medication use, health-related quality of life, opioid adverse effects, and healthcare utilization between targeted drug delivery and conservative medication management only groups.

NCT ID: NCT05645003 Recruiting - Clinical trials for Spinal Cord Injuries

Transcranial Magnetic Stimulation Therapy in Neuropathic Painful Spinal Cord Injury Patients

Start date: November 15, 2022
Phase: N/A
Study type: Interventional

The aim of our study is to investigate the effect of high-frequency Repetitive Transcranial Magnetic Stimulation(rTMS) therapy applied to the dorsolateral PFC (DLPFC) area on neuropathic pain in patients with spinal cord injury. In this area, there are very few studies on the effectiveness of rTMS treatment added to medical treatment in neuropathic pain. In addition, the number of studies comparing the effect of rTMS therapy applied to the DLFPC area is very few.

NCT ID: NCT05639946 Recruiting - Clinical trials for Spinal Cord Injuries

Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Start date: January 1, 2023
Phase: Phase 3
Study type: Interventional

Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to pharmacological intervention. Preliminary data suggest brivaracetam is a mechanism-based pharmacological intervention for neuropathic pain in SCI. Based on this and other reports in the literature, SCI-related neuropathic pain is hypothesized to occur largely because of upregulation of synaptic vesicle protein 2A (SV2A) within the substantia gelatinosa of the injured spinal cord. Furthermore, compared to placebo, brivaracetam treatment is hypothesized to reduce severe below-level SCI neuropathic pain and increases parietal operculum (partsOP1/OP4) connectivity strength measured by resting-state functional Magnetic Resonance Imaging (rsfMRI). Circulating miRNA-485 levels may be associated with change in pain intensity due to brivaracetam treatment. The study aims to determine the efficacy of brivaracetam treatment for SCI-related neuropathic pain.

NCT ID: NCT05639322 Recruiting - Neuropathic Pain Clinical Trials

Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial

PSYKED-NP
Start date: October 12, 2023
Phase: Phase 4
Study type: Interventional

The purpose of the study is to investigate new therapies to alleviate pain on neuropathic chronic pain. At this time, the main purpose is to complete a feasibility or pilot study with 60 participants suffering from neuropathic chronic pain. Participants will be randomized to (1) Ketamine (Hydrochloride) HCL; (2) psychotherapy (using Cognitive Behavioral Therapy); or (3) a combination of Ketamine HL and psychotherapy.

NCT ID: NCT05630235 Not yet recruiting - Neuropathic Pain Clinical Trials

Effects of Cannabidiol (CBD) on Resting-state Electroencephalography (EEG) and Neuropathic Pain Severity in People With Spinal Cord Injury (SCI)

Start date: September 1, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

The main purposes of this study are to (1) measure the effect of CBD on pain symptoms, pain intensity, pain unpleasantness, and skin sensitivity to hot and cold temperature; and (2) measure the effect of CBD on brain electrical activity with electroencephalography (EEG).

NCT ID: NCT05624853 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Randomized, Active-controlled, Parallel, Open-label, Multicenter, Phase 4 Study to Compare the Efficacy and Safety of Pregabalin Sustained Release Tablet and Pregabalin Immediate Release Capsule in Type II Diabetic Patients With Peripheral Neuropathic Pain

Start date: May 12, 2020
Phase: Phase 4
Study type: Interventional

This study is to compare the efficacy and safety of pregabalin sustained release tablet and pregabalin immediate release capsule in type II diabetic patients with peripheral neuropathic pain.

NCT ID: NCT05620225 Active, not recruiting - Neuropathic Pain Clinical Trials

Axon Therapy and Conventional Medical Management for Painful Diabetic Neuropathy Compared to Sham and Conventional Medical Management

Start date: December 15, 2022
Phase: N/A
Study type: Interventional

Compare Axon Therapy plus conventional medical management (CMM) to Sham plus CMM in reducing neuropathic pain in patients with painful diabetic neuropathy (PDM).

NCT ID: NCT05589935 Completed - Pain Clinical Trials

Radicle Relief 1: A Study of Health and Wellness Products on Pain and Other Health Outcomes

Start date: November 22, 2022
Phase: N/A
Study type: Interventional

A randomized, blinded, placebo-controlled study assessing the impact of health and wellness products on pain and other health outcomes

NCT ID: NCT05581836 Completed - Neuropathic Pain Clinical Trials

The Effect of Central Sensitization and Neuropathic Pain After Total Knee Arthroplasty

Start date: January 1, 2019
Phase:
Study type: Observational

It has been well known that central sensitization (CS) is a risk factor for inferior outcomes following total knee arthroplasty (TKA). However, there are still insufficient studies on the relationship between CS and neuropathic pain (NP), and the effects of CS and NP on the patient-reported outcome measures (PROMs) of patients who underwent TKA. The purpose of this study was to investigate the relationship between CS and NP and whether CS and NP were associated with PROM in patients undergoing TKA.

NCT ID: NCT05561257 Recruiting - Neuropathic Pain Clinical Trials

Vitamin C as add-on Therapy in Patients With Acute Herpes Zoster

Start date: July 20, 2020
Phase: Phase 2
Study type: Interventional

To compare the efficacy and tolerability of three different doses of Pascorbin® besides standard medication with placebo and the reduction of herpes zoster-associated clinical symptoms as an add-on therapy for patients suffering from acute herpes zoster in primary care